node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bud31 | Crnkl1 | ENSMUSP00000125564 | ENSMUSP00000001818 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | 0.998 |
Bud31 | Dnajc5b | ENSMUSP00000125564 | ENSMUSP00000113414 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | DnaJ homolog subfamily C member 5B. | 0.726 |
Bud31 | Plrg1 | ENSMUSP00000125564 | ENSMUSP00000114968 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Pleiotropic regulator 1; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. | 0.997 |
Bud31 | Prpf19 | ENSMUSP00000125564 | ENSMUSP00000136858 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | 0.997 |
Bud31 | Snw1 | ENSMUSP00000125564 | ENSMUSP00000021428 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] | 0.998 |
Bud31 | Tfip11 | ENSMUSP00000125564 | ENSMUSP00000031288 | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] | 0.979 |
Crnkl1 | Bud31 | ENSMUSP00000001818 | ENSMUSP00000125564 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | 0.998 |
Crnkl1 | Dnajc5b | ENSMUSP00000001818 | ENSMUSP00000113414 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | DnaJ homolog subfamily C member 5B. | 0.740 |
Crnkl1 | Hspa8 | ENSMUSP00000001818 | ENSMUSP00000015800 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.555 |
Crnkl1 | Plrg1 | ENSMUSP00000001818 | ENSMUSP00000114968 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | Pleiotropic regulator 1; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. | 0.998 |
Crnkl1 | Prpf19 | ENSMUSP00000001818 | ENSMUSP00000136858 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | Pre-mRNA-processing factor 19; [Isoform 1]: Ubiquitin-protein ligase which is a core component of several complexes mainly involved in pre-mRNA splicing and DNA repair. Required for pre-mRNA splicing as component of the spliceosome. Core component of the PRP19C/Prp19 complex/NTC/Nineteen complex which is part of the spliceosome and participates in its assembly, its remodeling and is required for its activity. During assembly of the spliceosome, mediates 'Lys-63'-linked polyubiquitination of the U4 spliceosomal protein PRPF3. Ubiquitination of PRPF3 allows its recognition by the U5 comp [...] | 0.997 |
Crnkl1 | Snw1 | ENSMUSP00000001818 | ENSMUSP00000021428 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | SNW domain-containing protein 1; Involved in pre-mRNA splicing as component of the spliceosome. Is required in the specific splicing of CDKN1A pre-mRNA; the function probably involves the recruitment of U2AF2 to the mRNA. Is proposed to recruit PPIL1 to the spliceosome. May be involved in cyclin-D1/CCND1 mRNA stability through the SNARP complex which associates with both the 3'end of the CCND1 gene and its mRNA. Involved in transcriptional regulation. Modulates TGF-beta-mediated transcription via association with SMAD proteins, MYOD1-mediated transcription via association with PABPN1, [...] | 0.999 |
Crnkl1 | Tfip11 | ENSMUSP00000001818 | ENSMUSP00000031288 | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | Tuftelin-interacting protein 11; Involved in pre-mRNA splicing, specifically in spliceosome disassembly during late-stage splicing events. Intron turnover seems to proceed through reactions in two lariat-intron associated complexes termed Intron Large (IL) and Intron Small (IS). In cooperation with DHX15 seems to mediate the transition of the U2, U5 and U6 snRNP- containing IL complex to the snRNP-free IS complex leading to efficient debranching and turnover of excised introns. May play a role in the differentiation of ameloblasts and odontoblasts or in the forming of the enamel extrac [...] | 0.991 |
Dnajc5b | Bud31 | ENSMUSP00000113414 | ENSMUSP00000125564 | DnaJ homolog subfamily C member 5B. | Protein BUD31 homolog; Involved in the pre-mRNA splicing process. May play a role as regulator of AR transcriptional activity; may increase AR transcriptional activity. | 0.726 |
Dnajc5b | Crnkl1 | ENSMUSP00000113414 | ENSMUSP00000001818 | DnaJ homolog subfamily C member 5B. | Crooked neck-like protein 1; Involved in pre-mRNA splicing process. | 0.740 |
Dnajc5b | Hspa13 | ENSMUSP00000113414 | ENSMUSP00000048817 | DnaJ homolog subfamily C member 5B. | Heat shock 70 kDa protein 13; Has peptide-independent ATPase activity; Belongs to the heat shock protein 70 family. | 0.705 |
Dnajc5b | Hspa1l | ENSMUSP00000113414 | ENSMUSP00000007248 | DnaJ homolog subfamily C member 5B. | Heat shock 70 kDa protein 1-like; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis an [...] | 0.645 |
Dnajc5b | Hspa8 | ENSMUSP00000113414 | ENSMUSP00000015800 | DnaJ homolog subfamily C member 5B. | Heat shock cognate 71 kDa protein; Molecular chaperone implicated in a wide variety of cellular processes, including protection of the proteome from stress, folding and transport of newly synthesized polypeptides, activation of proteolysis of misfolded proteins and the formation and dissociation of protein complexes. Plays a pivotal role in the protein quality control system, ensuring the correct folding of proteins, the re-folding of misfolded proteins and controlling the targeting of proteins for subsequent degradation. This is achieved through cycles of ATP binding, ATP hydrolysis a [...] | 0.650 |
Dnajc5b | Hspa9 | ENSMUSP00000113414 | ENSMUSP00000025217 | DnaJ homolog subfamily C member 5B. | Stress-70 protein, mitochondrial; Chaperone protein which plays an important role in mitochondrial iron-sulfur cluster (ISC) biogenesis. Interacts with and stabilizes ISC cluster assembly proteins FXN, NFU1, NFS1 and ISCU (By similarity). Regulates erythropoiesis via stabilization of ISC assembly. May play a role in the control of cell proliferation and cellular aging. Belongs to the heat shock protein 70 family. | 0.664 |
Dnajc5b | Plrg1 | ENSMUSP00000113414 | ENSMUSP00000114968 | DnaJ homolog subfamily C member 5B. | Pleiotropic regulator 1; Involved in pre-mRNA splicing as component of the spliceosome. Component of the PRP19-CDC5L complex that forms an integral part of the spliceosome and is required for activating pre- mRNA splicing. | 0.733 |