node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atp6v0a2 | Gpr89 | ENSMUSP00000039737 | ENSMUSP00000029738 | V-type proton ATPase 116 kDa subunit a isoform 2; Part of the proton channel of V-ATPases (By similarity). Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity); Belongs to the V-ATPase 116 kDa subunit family. | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | 0.548 |
Cog2 | Gpr89 | ENSMUSP00000034460 | ENSMUSP00000029738 | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function. | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | 0.500 |
Gpr152 | Gpr89 | ENSMUSP00000094062 | ENSMUSP00000029738 | Probable G-protein coupled receptor 152; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | 0.597 |
Gpr89 | Atp6v0a2 | ENSMUSP00000029738 | ENSMUSP00000039737 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | V-type proton ATPase 116 kDa subunit a isoform 2; Part of the proton channel of V-ATPases (By similarity). Essential component of the endosomal pH-sensing machinery. May play a role in maintaining the Golgi functions, such as glycosylation maturation, by controlling the Golgi pH. In aerobic conditions, involved in intracellular iron homeostasis, thus triggering the activity of Fe(2+) prolyl hydroxylase (PHD) enzymes, and leading to HIF1A hydroxylation and subsequent proteasomal degradation (By similarity); Belongs to the V-ATPase 116 kDa subunit family. | 0.548 |
Gpr89 | Cog2 | ENSMUSP00000029738 | ENSMUSP00000034460 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | Conserved oligomeric Golgi complex subunit 2; Required for normal Golgi morphology and function. | 0.500 |
Gpr89 | Gpr152 | ENSMUSP00000029738 | ENSMUSP00000094062 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | Probable G-protein coupled receptor 152; Orphan receptor; Belongs to the G-protein coupled receptor 1 family. | 0.597 |
Gpr89 | Gtpbp8 | ENSMUSP00000029738 | ENSMUSP00000125352 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | GTP-binding protein 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | 0.647 |
Gpr89 | Mysm1 | ENSMUSP00000029738 | ENSMUSP00000075269 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | 0.540 |
Gpr89 | Osbpl5 | ENSMUSP00000029738 | ENSMUSP00000020411 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | Oxysterol-binding protein-related protein 5; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol. | 0.794 |
Gpr89 | Osbpl8 | ENSMUSP00000029738 | ENSMUSP00000100911 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | Oxysterol-binding protein-related protein 8; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. | 0.840 |
Gpr89 | Rer1 | ENSMUSP00000029738 | ENSMUSP00000030914 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | Protein RER1; Involved in the retrieval of endoplasmic reticulum membrane proteins from the early Golgi compartment; Belongs to the RER1 family. | 0.503 |
Gpr89 | Spryd4 | ENSMUSP00000029738 | ENSMUSP00000054731 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | SPRY domain-containing protein 4. | 0.505 |
Gpr89 | Trmt6 | ENSMUSP00000029738 | ENSMUSP00000044687 | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | tRNA (adenine(58)-N(1))-methyltransferase non-catalytic subunit TRM6; Substrate-binding subunit of tRNA (adenine-N(1)-)- methyltransferase, which catalyzes the formation of N(1)-methyladenine at position 58 (m1A58) in initiator methionyl-tRNA. Together with the TRMT61A catalytic subunit, part of a mRNA N(1)-methyltransferase complex that mediates methylation of adenosine residues at the N(1) position of a small subset of mRNAs: N(1) methylation takes place in tRNA T-loop-like structures of mRNAs and is only present at low stoichiometries; Belongs to the TRM6/GCD10 family. | 0.505 |
Gtpbp8 | Gpr89 | ENSMUSP00000125352 | ENSMUSP00000029738 | GTP-binding protein 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | 0.647 |
Gtpbp8 | Spryd4 | ENSMUSP00000125352 | ENSMUSP00000054731 | GTP-binding protein 8; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngB GTPase family. | SPRY domain-containing protein 4. | 0.542 |
Mysm1 | Gpr89 | ENSMUSP00000075269 | ENSMUSP00000029738 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | 0.540 |
Osbpl5 | Gpr89 | ENSMUSP00000020411 | ENSMUSP00000029738 | Oxysterol-binding protein-related protein 5; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol. | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | 0.794 |
Osbpl5 | Osbpl8 | ENSMUSP00000020411 | ENSMUSP00000100911 | Oxysterol-binding protein-related protein 5; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol. | Oxysterol-binding protein-related protein 8; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. | 0.528 |
Osbpl8 | Gpr89 | ENSMUSP00000100911 | ENSMUSP00000029738 | Oxysterol-binding protein-related protein 8; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. | Golgi pH regulator; Voltage dependent anion channel required for acidification and functions of the Golgi apparatus that may function in counter-ion conductance. | 0.840 |
Osbpl8 | Osbpl5 | ENSMUSP00000100911 | ENSMUSP00000020411 | Oxysterol-binding protein-related protein 8; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. Binds oxysterol, 25-hydroxycholesterol and cholesterol. | Oxysterol-binding protein-related protein 5; Lipid transporter involved in lipid countertransport between the endoplasmic reticulum and the plasma membrane: specifically exchanges phosphatidylserine with phosphatidylinositol 4-phosphate (PI4P), delivering phosphatidylserine to the plasma membrane in exchange for PI4P, which is degraded by the SAC1/SACM1L phosphatase in the endoplasmic reticulum. Binds phosphatidylserine and PI4P in a mutually exclusive manner. May cooperate with NPC1 to mediate the exit of cholesterol from endosomes/lysosomes. Binds 25-hydroxycholesterol and cholesterol. | 0.528 |