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Tspan5 protein (mouse) - STRING interaction network
"Tspan5" - Tetraspanin-5 in Mus musculus
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
some 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Tspan5Tetraspanin-5; Regulates ADAM10 maturation and trafficking to the cell surface. Promotes ADAM10-mediated cleavage of CD44 (By similarity) (268 aa)    
Predicted Functional Partners:
BC007180
Glutamate-rich 3; cDNA sequence BC007180 (889 aa)
     
   
  0.802
Erich3
RIKEN cDNA 1700013E18, isoform CRA_b; Glutamate rich 3 (517 aa)
     
   
  0.790
Adam10
Disintegrin and metalloproteinase domain-containing protein 10; Cleaves the membrane-bound precursor of TNF-alpha to its mature soluble form. Responsible for the proteolytical release of soluble JAM3 from endothelial cells surface (By similarity). Responsible for the proteolytic release of several other cell- surface proteins, including heparin-binding epidermal growth-like factor, ephrin-A2, CD44, CDH2 and for constitutive and regulated alpha-secretase cleavage of amyloid precursor protein (APP) at ’687-Lys-|-Leu-688’ (By similarity). Contributes to the normal cleavage of the cellular [...] (749 aa)
     
 
  0.682
Metap1
Methionine aminopeptidase 1; Cotranslationally removes the N-terminal methionine from nascent proteins. The N-terminal methionine is often cleaved when the second residue in the primary sequence is small and uncharged (Met-Ala-, Cys, Gly, Pro, Ser, Thr, or Val) (386 aa)
           
  0.667
mCG_120169
RIKEN cDNA 2310050C09 gene (280 aa)
       
 
  0.578
Tmem14c
Transmembrane protein 14C; Required for normal heme biosynthesis (114 aa)
           
  0.547
Sbsn
Suprabasin (682 aa)
           
  0.542
Duox2
Dual oxidase 2 (1517 aa)
           
  0.541
Tspan32
Tetraspanin-32; Tetraspanin 32; Belongs to the tetraspanin (TM4SF) family (256 aa)
           
  0.538
Ptgfrn
Prostaglandin F2 receptor negative regulator; Inhibits the binding of prostaglandin F2-alpha (PGF2- alpha) to its specific FP receptor, by decreasing the receptor number rather than the affinity constant. Functional coupling with the prostaglandin F2-alpha receptor seems to occur (By similarity) (879 aa)
       
 
  0.537
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus muscaris, Mus musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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