node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
B4galt2 | Ccdc24 | ENSMUSP00000030266 | ENSMUSP00000132114 | Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity). | Coiled-coil domain-containing 24. | 0.566 |
B4galt2 | Eri3 | ENSMUSP00000030266 | ENSMUSP00000042796 | Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity). | ERI1 exoribonuclease 3. | 0.425 |
B4galt2 | Rnf220 | ENSMUSP00000030266 | ENSMUSP00000030439 | Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity). | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | 0.454 |
Ccdc24 | B4galt2 | ENSMUSP00000132114 | ENSMUSP00000030266 | Coiled-coil domain-containing 24. | Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity). | 0.566 |
Ccdc24 | Eri3 | ENSMUSP00000132114 | ENSMUSP00000042796 | Coiled-coil domain-containing 24. | ERI1 exoribonuclease 3. | 0.630 |
Ccdc24 | Rnf220 | ENSMUSP00000132114 | ENSMUSP00000030439 | Coiled-coil domain-containing 24. | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | 0.645 |
Ctnnb1 | Rnf220 | ENSMUSP00000007130 | ENSMUSP00000030439 | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | 0.526 |
Cul7 | Rnf220 | ENSMUSP00000049128 | ENSMUSP00000030439 | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | 0.466 |
Dbx2 | Rnf220 | ENSMUSP00000060424 | ENSMUSP00000030439 | Developing brain homeobox 2. | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | 0.444 |
Dbx2 | Zc4h2 | ENSMUSP00000060424 | ENSMUSP00000041236 | Developing brain homeobox 2. | Zinc finger C4H2 domain-containing protein; Plays a role in interneurons differentiation. Involved in neuronal development and in neuromuscular junction formation. | 0.489 |
Eri3 | B4galt2 | ENSMUSP00000042796 | ENSMUSP00000030266 | ERI1 exoribonuclease 3. | Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity). | 0.425 |
Eri3 | Ccdc24 | ENSMUSP00000042796 | ENSMUSP00000132114 | ERI1 exoribonuclease 3. | Coiled-coil domain-containing 24. | 0.630 |
Eri3 | Rnf220 | ENSMUSP00000042796 | ENSMUSP00000030439 | ERI1 exoribonuclease 3. | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | 0.662 |
Eri3 | Tmem53 | ENSMUSP00000042796 | ENSMUSP00000102042 | ERI1 exoribonuclease 3. | Transmembrane protein 53; Belongs to the TMEM53 family. | 0.724 |
Rnf220 | B4galt2 | ENSMUSP00000030439 | ENSMUSP00000030266 | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | Beta-1,4-galactosyltransferase 2; Responsible for the synthesis of complex-type N-linked oligosaccharides in many glycoproteins as well as the carbohydrate moieties of glycolipids. Can produce lactose (By similarity). | 0.454 |
Rnf220 | Ccdc24 | ENSMUSP00000030439 | ENSMUSP00000132114 | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | Coiled-coil domain-containing 24. | 0.645 |
Rnf220 | Ctnnb1 | ENSMUSP00000030439 | ENSMUSP00000007130 | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | Catenin beta-1; Key downstream component of the canonical Wnt signaling pathway. In the absence of Wnt, forms a complex with AXIN1, AXIN2, APC, CSNK1A1 and GSK3B that promotes phosphorylation on N-terminal Ser and Thr residues and ubiquitination of CTNNB1 via BTRC and its subsequent degradation by the proteasome. In the presence of Wnt ligand, CTNNB1 is not ubiquitinated and accumulates in the nucleus, where it acts as a coactivator for transcription factors of the TCF/LEF family, leading to activate Wnt responsive genes. Involved in the regulation of cell adhesion, as component of an [...] | 0.526 |
Rnf220 | Cul7 | ENSMUSP00000030439 | ENSMUSP00000049128 | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | Cullin-7; Core component of the 3M and Cul7-RING(FBXW8) complexes, which mediates the ubiquitination of target proteins. Core component of the 3M complex, a complex required to regulate microtubule dynamics and genome integrity. It is unclear how the 3M complex regulates microtubules, it could act by controlling the level of a microtubule stabilizer. Interaction with CUL9 is required to inhibit CUL9 activity and ubiquitination of BIRC5. Core component of a Cul7-RING ubiquitin- protein ligase with FBXW8, which mediates ubiquitination and consequent degradation of target proteins such as [...] | 0.466 |
Rnf220 | Dbx2 | ENSMUSP00000030439 | ENSMUSP00000060424 | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | Developing brain homeobox 2. | 0.444 |
Rnf220 | Eri3 | ENSMUSP00000030439 | ENSMUSP00000042796 | E3 ubiquitin-protein ligase Rnf220; E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of SIN3B. Independently of its E3 ligase activity, acts as a CTNNB1 stabilizer through USP7- mediated deubiquitination of CTNNB1 and promotes Wnt signaling (By similarity). | ERI1 exoribonuclease 3. | 0.662 |