STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Gbp9Guanylate-binding protein 9. (619 aa)    
Predicted Functional Partners:
Irgm2
Immunity-related GTPase family M member 2.
   
  
 0.547
Igtp
Interferon gamma-induced GTPase.
   
  
 0.503
Tgtp2
T-cell-specific guanine nucleotide triphosphate-binding protein 1; Involved in innate cell-autonomous resistance to intracellular pathogens, such as Toxoplasma gondii. During avirulent type II T. gondii infection, recruited to the parasitophorous vacuole (PV) membrane, leading to PV vesiculation and rupture, and subsequent digestion of the parasite within the cytosol. Not recruited to virulent type I T. gondii PV membrane. May confer an antiviral state for vesicular stomatitis virus.
   
  
 0.499
Iigp1
Interferon-inducible GTPase 1; GTPase with low activity. Has higher affinity for GDP than for GTP. Plays a role in resistance to intracellular pathogens. Required for disruption of the parasitophorous vacuole formed following T.gondii infection and subsequent killing of the parasite. Mediates resistance to C.trachomatis infection by targeting bacterial inclusions to autophagosomes for subsequent lysosomal destruction. Belongs to the TRAFAC class dynamin-like GTPase superfamily. IRG family.
   
  
 0.472
Tgtp1
T cell specific GTPase 1.
   
  
 0.469
Trim34b
Tripartite motif-containing 34B.
   
  
 0.462
F830016B08Rik
Interferon-gamma-inducible GTPase Ifgga4 protein.
   
  
 0.435
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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