node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acss2 | Aldh2 | ENSMUSP00000029135 | ENSMUSP00000031411 | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | 0.943 |
Acss2 | Aldh6a1 | ENSMUSP00000029135 | ENSMUSP00000082288 | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). | 0.927 |
Acss2 | Aox1 | ENSMUSP00000029135 | ENSMUSP00000001027 | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imid [...] | 0.828 |
Acss2 | Aox2 | ENSMUSP00000029135 | ENSMUSP00000110006 | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde oxidase 2; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Cannot use hypoxanthine as substrate. | 0.814 |
Acss2 | Aox3 | ENSMUSP00000029135 | ENSMUSP00000049391 | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde oxidase 3; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with N [...] | 0.815 |
Acss2 | Aox4 | ENSMUSP00000029135 | ENSMUSP00000048929 | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | Aldehyde oxidase 4; Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all-trans- retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles. Belongs to the xanthine dehydrogenase family. | 0.802 |
Acss2 | Hadh | ENSMUSP00000029135 | ENSMUSP00000029610 | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. | 0.888 |
Aldh2 | Acss2 | ENSMUSP00000031411 | ENSMUSP00000029135 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.943 |
Aldh2 | Aldh6a1 | ENSMUSP00000031411 | ENSMUSP00000082288 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). | 0.943 |
Aldh2 | Aoc3 | ENSMUSP00000031411 | ENSMUSP00000099394 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Membrane primary amine oxidase; Cell adhesion protein that participates in lymphocyte recirculation by mediating the binding of lymphocytes to peripheral lymph node vascular endothelial cells in an L-selectin-independent fashion. Has a monoamine oxidase activity. May play a role in adipogenesis (By similarity). | 0.949 |
Aldh2 | Aox1 | ENSMUSP00000031411 | ENSMUSP00000001027 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imid [...] | 0.945 |
Aldh2 | Aox2 | ENSMUSP00000031411 | ENSMUSP00000110006 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Aldehyde oxidase 2; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as phthalazine, as well as aldehydes, such as benzaldehyde and retinal. Cannot use hypoxanthine as substrate. | 0.943 |
Aldh2 | Aox3 | ENSMUSP00000031411 | ENSMUSP00000049391 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Aldehyde oxidase 3; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide and phthalazine, as well as aldehydes, such as benzaldehyde, retinal and pyridoxal. Plays a key role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Is probably involved in the regulation of reactive oxygen species homeostasis. May be a prominent source of superoxide generation via the one-electron reduction of molecular oxygen. Also may catalyze nitric oxide (NO) production via the reduction of nitrite to NO with N [...] | 0.946 |
Aldh2 | Aox4 | ENSMUSP00000031411 | ENSMUSP00000048929 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Aldehyde oxidase 4; Aldehyde oxidase able to catalyze the oxidation of retinaldehyde into retinoate. Is responsible for the major all-trans- retinaldehyde-metabolizing activity in the Harderian gland, and contributes a significant amount of the same activity in the skin. Is devoid of pyridoxal-oxidizing activity, in contrast to the other aldehyde oxidases. Acts as a negative modulator of the epidermal trophism. May be able to oxidize a wide variety of aldehydes into their corresponding carboxylates and to hydroxylate azaheterocycles. Belongs to the xanthine dehydrogenase family. | 0.944 |
Aldh2 | Hadh | ENSMUSP00000031411 | ENSMUSP00000029610 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Hydroxyacyl-coenzyme A dehydrogenase, mitochondrial; Plays an essential role in the mitochondrial beta-oxidation of short chain fatty acids. Exerts it highest activity toward 3- hydroxybutyryl-CoA; Belongs to the 3-hydroxyacyl-CoA dehydrogenase family. | 0.954 |
Aldh2 | Maoa | ENSMUSP00000031411 | ENSMUSP00000026013 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Amine oxidase [flavin-containing] A; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOA preferentially oxidizes biogenic amines such as 5-hydroxytryptamine (5-HT), norepinephrine and epinephrine (By similarity). | 0.944 |
Aldh2 | Maob | ENSMUSP00000031411 | ENSMUSP00000040550 | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | Amine oxidase [flavin-containing] B; Catalyzes the oxidative deamination of biogenic and xenobiotic amines and has important functions in the metabolism of neuroactive and vasoactive amines in the central nervous system and peripheral tissues. MAOB preferentially degrades benzylamine and phenylethylamine (By similarity). | 0.944 |
Aldh6a1 | Acss2 | ENSMUSP00000082288 | ENSMUSP00000029135 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). | Acetyl-coenzyme A synthetase, cytoplasmic; Catalyzes the synthesis of acetyl-CoA from short-chain fatty acids. Acetate is the preferred substrate but can also utilize propionate with a much lower affinity ; Belongs to the ATP-dependent AMP-binding enzyme family. | 0.927 |
Aldh6a1 | Aldh2 | ENSMUSP00000082288 | ENSMUSP00000031411 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). | Aldehyde dehydrogenase, mitochondrial; Is capable of converting retinaldehyde to retinoic acid. | 0.943 |
Aldh6a1 | Aox1 | ENSMUSP00000082288 | ENSMUSP00000001027 | Methylmalonate-semialdehyde dehydrogenase [acylating], mitochondrial; Plays a role in valine and pyrimidine metabolism. Binds fatty acyl-CoA (By similarity). | Aldehyde oxidase 1; Oxidase with broad substrate specificity, oxidizing aromatic azaheterocycles, such as N1-methylnicotinamide, N-methylphthalazinium and phthalazine, as well as aldehydes, such as benzaldehyde, retinal, pyridoxal, and vanillin. Plays a role in the metabolism of xenobiotics and drugs containing aromatic azaheterocyclic substituents. Participates in the bioactivation of prodrugs such as famciclovir, catalyzing the oxidation step from 6-deoxypenciclovir to penciclovir, which is a potent antiviral agent. Also plays a role in the reductive metabolism of the xenobiotic imid [...] | 0.916 |