node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Caskin2 | Fbxo24 | ENSMUSP00000041328 | ENSMUSP00000031732 | Caskin-2. | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.507 |
Caskin2 | Mrpl12 | ENSMUSP00000041328 | ENSMUSP00000044417 | Caskin-2. | 39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family. | 0.438 |
Dot1l | Fbxo24 | ENSMUSP00000100973 | ENSMUSP00000031732 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.538 |
Dot1l | Setdb2 | ENSMUSP00000100973 | ENSMUSP00000124696 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity). | 0.496 |
Dot1l | Skp1a | ENSMUSP00000100973 | ENSMUSP00000104700 | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.529 |
Fau | Fbxo24 | ENSMUSP00000136358 | ENSMUSP00000031732 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.583 |
Fau | Mrpl12 | ENSMUSP00000136358 | ENSMUSP00000044417 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family. | 0.415 |
Fau | Rpl17 | ENSMUSP00000136358 | ENSMUSP00000157556 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 60S ribosomal protein L17; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL22 family. | 0.999 |
Fau | Skp1a | ENSMUSP00000136358 | ENSMUSP00000104700 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.567 |
Fau | Trip12 | ENSMUSP00000136358 | ENSMUSP00000027421 | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | E3 ubiquitin-protein ligase TRIP12; E3 ubiquitin-protein ligase involved in ubiquitin fusion degradation (UFD) pathway and regulation of DNA repair. Part of the ubiquitin fusion degradation (UFD) pathway, a process that mediates ubiquitination of protein at their N-terminus, regardless of the presence of lysine residues in target proteins. Acts as a key regulator of DNA damage response by acting as a suppressor of RNF168, an E3 ubiquitin-protein ligase that promotes accumulation of 'Lys-63'-linked histone H2A and H2AX at DNA damage sites, thereby acting as a guard against excessive spr [...] | 0.805 |
Fbxl12 | Fbxo24 | ENSMUSP00000119124 | ENSMUSP00000031732 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 0.456 |
Fbxl12 | Skp1a | ENSMUSP00000119124 | ENSMUSP00000104700 | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). | S-phase kinase-associated protein 1; Essential component of the SCF (SKP1-CUL1-F-box protein) ubiquitin ligase complex, which mediates the ubiquitination of proteins involved in cell cycle progression, signal transduction and transcription. In the SCF complex, serves as an adapter that links the F-box protein to CUL1. The functional specificity of the SCF complex depends on the F-box protein as substrate recognition component. SCF(BTRC) and SCF(FBXW11) direct ubiquitination of CTNNB1 and participate in Wnt signaling. SCF(FBXW11) directs ubiquitination of phosphorylated NFKBIA. SCF(BTRC [...] | 0.910 |
Fbxo24 | Caskin2 | ENSMUSP00000031732 | ENSMUSP00000041328 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Caskin-2. | 0.507 |
Fbxo24 | Dot1l | ENSMUSP00000031732 | ENSMUSP00000100973 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Histone-lysine N-methyltransferase, H3 lysine-79 specific. | 0.538 |
Fbxo24 | Fau | ENSMUSP00000031732 | ENSMUSP00000136358 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Ubiquitin-like protein FUBI; Belongs to the ubiquitin family. | 0.583 |
Fbxo24 | Fbxl12 | ENSMUSP00000031732 | ENSMUSP00000119124 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | F-box/LRR-repeat protein 12; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. Mediates the polyubiquitination and proteasomal degradation of CAMK1 leading to disruption of cyclin D1/CDK4 complex assembly which results in G1 cell cycle arrest in lung epithelia (By similarity). | 0.456 |
Fbxo24 | Mrpl12 | ENSMUSP00000031732 | ENSMUSP00000044417 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 39S ribosomal protein L12, mitochondrial; Belongs to the bacterial ribosomal protein bL12 family. | 0.529 |
Fbxo24 | Nub1 | ENSMUSP00000031732 | ENSMUSP00000143657 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | NEDD8 ultimate buster 1; Specific down-regulator of the NEDD8 conjugation system. Recruits NEDD8, UBD, and their conjugates to the proteasome for degradation (By similarity). | 0.441 |
Fbxo24 | Rpl17 | ENSMUSP00000031732 | ENSMUSP00000157556 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | 60S ribosomal protein L17; Component of the large ribosomal subunit. Belongs to the universal ribosomal protein uL22 family. | 0.455 |
Fbxo24 | Setdb2 | ENSMUSP00000031732 | ENSMUSP00000124696 | F-box only protein 24; Substrate-recognition component of the SCF (SKP1-CUL1-F-box protein)-type E3 ubiquitin ligase complex. | Histone-lysine N-methyltransferase SETDB2; Histone methyltransferase involved in left-right axis specification in early development and mitosis. Specifically trimethylates 'Lys-9' of histone H3 (H3K9me3). H3K9me3 is a specific tag for epigenetic transcriptional repression that recruits HP1 (CBX1, CBX3 and/or CBX5) proteins to methylated histones. Contributes to H3K9me3 in both the interspersed repetitive elements and centromere- associated repeats. Plays a role in chromosome condensation and segregation during mitosis (By similarity). | 0.523 |