node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cib4 | Lrguk | ENSMUSP00000066222 | ENSMUSP00000065146 | Calcium and integrin-binding family member 4. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.588 |
Cib4 | Spaca1 | ENSMUSP00000066222 | ENSMUSP00000029927 | Calcium and integrin-binding family member 4. | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | 0.418 |
Cib4 | Spef2 | ENSMUSP00000066222 | ENSMUSP00000035762 | Calcium and integrin-binding family member 4. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.609 |
Cib4 | Ssmem1 | ENSMUSP00000066222 | ENSMUSP00000031798 | Calcium and integrin-binding family member 4. | Serine-rich single-pass membrane protein 1. | 0.580 |
Cib4 | Tssk4 | ENSMUSP00000066222 | ENSMUSP00000007735 | Calcium and integrin-binding family member 4. | Testis-specific serine/threonine-protein kinase 4; [Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'. [Isoform 3]: Catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.591 |
Fam209 | Spaca1 | ENSMUSP00000029007 | ENSMUSP00000029927 | Family with sequence similarity 209. | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | 0.542 |
Fam209 | Ssmem1 | ENSMUSP00000029007 | ENSMUSP00000031798 | Family with sequence similarity 209. | Serine-rich single-pass membrane protein 1. | 0.655 |
Lrguk | Cib4 | ENSMUSP00000065146 | ENSMUSP00000066222 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Calcium and integrin-binding family member 4. | 0.588 |
Lrguk | Spaca1 | ENSMUSP00000065146 | ENSMUSP00000029927 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | 0.527 |
Lrguk | Spef2 | ENSMUSP00000065146 | ENSMUSP00000035762 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Sperm flagellar protein 2; Required for correct axoneme development in spermatozoa. Important for normal development of the manchette and sperm head morphology. Essential for male fertility. Plays a role in localization of the intraflagellar transport protein IFT20 to the manchette, suggesting function as an adapter for dynein-mediated protein transport during spermatogenesis. Also plays a role in bone growth where it seems to be required for normal osteoblast differentiation. | 0.754 |
Lrguk | Ssmem1 | ENSMUSP00000065146 | ENSMUSP00000031798 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Serine-rich single-pass membrane protein 1. | 0.695 |
Lrguk | Tssk4 | ENSMUSP00000065146 | ENSMUSP00000007735 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Testis-specific serine/threonine-protein kinase 4; [Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'. [Isoform 3]: Catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.626 |
Mtmr4 | Ssmem1 | ENSMUSP00000099468 | ENSMUSP00000031798 | Myotubularin-related protein 4; Dephosphorylates proteins phosphorylated on Ser, Thr, and Tyr residues and low molecular weight phosphatase substrate para- nitrophenylphosphate. Phosphorylates phosphatidylinositol 3,4,5- trisphosphate (PIP3) (By similarity); Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Serine-rich single-pass membrane protein 1. | 0.577 |
Spaca1 | Cib4 | ENSMUSP00000029927 | ENSMUSP00000066222 | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | Calcium and integrin-binding family member 4. | 0.418 |
Spaca1 | Fam209 | ENSMUSP00000029927 | ENSMUSP00000029007 | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | Family with sequence similarity 209. | 0.542 |
Spaca1 | Lrguk | ENSMUSP00000029927 | ENSMUSP00000065146 | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.527 |
Spaca1 | Spata46 | ENSMUSP00000029927 | ENSMUSP00000062245 | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | Spermatogenesis-associated protein 46; Plays a role in spermiogenesis and fertilization. | 0.782 |
Spaca1 | Ssmem1 | ENSMUSP00000029927 | ENSMUSP00000031798 | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | Serine-rich single-pass membrane protein 1. | 0.829 |
Spaca1 | Tssk4 | ENSMUSP00000029927 | ENSMUSP00000007735 | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | Testis-specific serine/threonine-protein kinase 4; [Isoform 1]: Serine/threonine kinase which is involved in male germ cell development and in mature sperm function. May be involved in the Cre/Creb signaling pathway. Phosphorylates CREB1 on 'Ser-133' in vitro and can stimulate Cre/Creb pathway in cells (By similarity). Phosphorylates CREM on 'Ser-116' in vitro. Phosphorylates ODF2 on 'Ser-95'. [Isoform 3]: Catalytically inactive. Belongs to the protein kinase superfamily. CAMK Ser/Thr protein kinase family. | 0.689 |
Spaca1 | Vps54 | ENSMUSP00000029927 | ENSMUSP00000006221 | Sperm acrosome membrane-associated protein 1; Plays a role in acrosome expansion and establishment of normal sperm morphology during spermatogenesis. Important for male fertility. | Vacuolar protein sorting-associated protein 54; Acts as component of the GARP complex that is involved in retrograde transport from early and late endosomes to the trans-Golgi network (TGN). The GARP complex is required for the maintenance of the cycling of mannose 6-phosphate receptors between the TGN and endosomes, this cycling is necessary for proper lysosomal sorting of acid hydrolases such as CTSD. Within the GARP complex, required to tether the complex to the TGN. Not involved in endocytic recycling. | 0.608 |