node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fdx2 | Iba57 | ENSMUSP00000010348 | ENSMUSP00000049823 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | 0.835 |
Fdx2 | Isca1 | ENSMUSP00000010348 | ENSMUSP00000054858 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. | 0.821 |
Fdx2 | Isca2 | ENSMUSP00000010348 | ENSMUSP00000021667 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | Iron-sulfur cluster assembly 2 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. Belongs to the HesB/IscA family. | 0.886 |
Fdx2 | Iscu | ENSMUSP00000010348 | ENSMUSP00000026937 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. C [...] | 0.983 |
Fdx2 | Lias | ENSMUSP00000010348 | ENSMUSP00000113228 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family. | 0.686 |
Fdx2 | Lyrm4 | ENSMUSP00000010348 | ENSMUSP00000060779 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | 0.967 |
Fdx2 | Ndufs8 | ENSMUSP00000010348 | ENSMUSP00000158541 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | NADH dehydrogenase [ubiquinone] iron-sulfur protein 8, mitochondrial; Core subunit of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I) that is believed to belong to the minimal assembly required for catalysis. Complex I functions in the transfer of electrons from NADH to the respiratory chain. The immediate electron acceptor for the enzyme is believed to be ubiquinone (By similarity). | 0.901 |
Fdx2 | Nfs1 | ENSMUSP00000010348 | ENSMUSP00000029147 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters. May be involved in the biosynthesis of molybdenum cofactor (By similarity); Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.972 |
Fdx2 | Nfu1 | ENSMUSP00000010348 | ENSMUSP00000113637 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; Iron-sulfur cluster scaffold protein which can assemble [4Fe- 4S] clusters and deliver them to target proteins. | 0.865 |
Fdx2 | Sdhb | ENSMUSP00000010348 | ENSMUSP00000010007 | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.419 |
Iba57 | Fdx2 | ENSMUSP00000049823 | ENSMUSP00000010348 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | 0.835 |
Iba57 | Isca1 | ENSMUSP00000049823 | ENSMUSP00000054858 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. | 0.967 |
Iba57 | Isca2 | ENSMUSP00000049823 | ENSMUSP00000021667 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | Iron-sulfur cluster assembly 2 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. May be involved in the binding of an intermediate of Fe/S cluster assembly. Belongs to the HesB/IscA family. | 0.980 |
Iba57 | Iscu | ENSMUSP00000049823 | ENSMUSP00000026937 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | Iron-sulfur cluster assembly enzyme ISCU, mitochondrial; Scaffold protein for the de novo synthesis of iron-sulfur (Fe-S) clusters within mitochondria, which is required for maturation of both mitochondrial and cytoplasmic [2Fe-2S] and [4Fe-4S] proteins. First, a [2Fe-2S] cluster is transiently assembled on the scaffold protein ISCU. In a second step, the cluster is released from ISCU, transferred to a glutaredoxin GLRX5, followed by the formation of mitochondrial [2Fe-2S] proteins, the synthesis of [4Fe-4S] clusters and their target-specific insertion into the recipient apoproteins. C [...] | 0.855 |
Iba57 | Lias | ENSMUSP00000049823 | ENSMUSP00000113228 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | Lipoyl synthase, mitochondrial; Catalyzes the radical-mediated insertion of two sulfur atoms into the C-6 and C-8 positions of the octanoyl moiety bound to the lipoyl domains of lipoate-dependent enzymes, thereby converting the octanoylated domains into lipoylated derivatives; Belongs to the radical SAM superfamily. Lipoyl synthase family. | 0.895 |
Iba57 | Lyrm4 | ENSMUSP00000049823 | ENSMUSP00000060779 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | LYR motif-containing protein 4; Required for nuclear and mitochondrial iron-sulfur protein biosynthesis; Belongs to the complex I LYR family. | 0.872 |
Iba57 | Nfs1 | ENSMUSP00000049823 | ENSMUSP00000029147 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | Cysteine desulfurase, mitochondrial; Catalyzes the removal of elemental sulfur from cysteine to produce alanine. It supplies the inorganic sulfur for iron-sulfur (Fe- S) clusters. May be involved in the biosynthesis of molybdenum cofactor (By similarity); Belongs to the class-V pyridoxal-phosphate-dependent aminotransferase family. NifS/IscS subfamily. | 0.867 |
Iba57 | Nfu1 | ENSMUSP00000049823 | ENSMUSP00000113637 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | NFU1 iron-sulfur cluster scaffold homolog, mitochondrial; Iron-sulfur cluster scaffold protein which can assemble [4Fe- 4S] clusters and deliver them to target proteins. | 0.928 |
Iba57 | Sdhb | ENSMUSP00000049823 | ENSMUSP00000010007 | Putative transferase CAF17 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Belongs to the GcvT family. CAF17 subfamily. | Succinate dehydrogenase [ubiquinone] iron-sulfur subunit, mitochondrial; Iron-sulfur protein (IP) subunit of succinate dehydrogenase (SDH) that is involved in complex II of the mitochondrial electron transport chain and is responsible for transferring electrons from succinate to ubiquinone (coenzyme Q). | 0.503 |
Isca1 | Fdx2 | ENSMUSP00000054858 | ENSMUSP00000010348 | Iron-sulfur cluster assembly 1 homolog, mitochondrial; Involved in the maturation of mitochondrial 4Fe-4S proteins functioning late in the iron-sulfur cluster assembly pathway. Probably involved in the binding of an intermediate of Fe/S cluster assembly. | Ferredoxin-2, mitochondrial; Essential for heme A and Fe/S protein biosynthesis. Belongs to the adrenodoxin/putidaredoxin family. | 0.821 |