node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arsa | Arsb | ENSMUSP00000127646 | ENSMUSP00000088964 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | 0.954 |
Arsa | Arsg | ENSMUSP00000127646 | ENSMUSP00000020928 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | 0.915 |
Arsa | Arsi | ENSMUSP00000127646 | ENSMUSP00000043966 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts; Belongs to the sulfatase family. | 0.615 |
Arsa | Arsj | ENSMUSP00000127646 | ENSMUSP00000091511 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Arylsulfatase J. | 0.615 |
Arsa | Galns | ENSMUSP00000127646 | ENSMUSP00000015171 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | N-acetylgalactosamine-6-sulfatase; Belongs to the sulfatase family. | 0.582 |
Arsa | Gns | ENSMUSP00000127646 | ENSMUSP00000043167 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. | 0.476 |
Arsa | Ids | ENSMUSP00000127646 | ENSMUSP00000099046 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Iduronate 2-sulfatase; Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. | 0.450 |
Arsa | Sgsh | ENSMUSP00000127646 | ENSMUSP00000005173 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | N-sulfoglucosamine sulfohydrolase (sulfamidase). | 0.549 |
Arsa | Sumf1 | ENSMUSP00000127646 | ENSMUSP00000032191 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family. | 0.900 |
Arsa | Sumf2 | ENSMUSP00000127646 | ENSMUSP00000126036 | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.776 |
Arsb | Arsa | ENSMUSP00000088964 | ENSMUSP00000127646 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase A; Hydrolyzes cerebroside sulfate. Belongs to the sulfatase family. | 0.954 |
Arsb | Arsg | ENSMUSP00000088964 | ENSMUSP00000020928 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase G; Displays arylsulfatase activity with pseudosubstrates at acidic pH, such as p-nitrocatechol sulfate. Belongs to the sulfatase family. | 0.951 |
Arsb | Arsi | ENSMUSP00000088964 | ENSMUSP00000043966 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase I; Displays arylsulfatase activity at neutral pH, when co- expressed with SUMF1; arylsulfatase activity is measured in the secretion medium of retinal cell line, but no activity is recorded when measured in cell extracts; Belongs to the sulfatase family. | 0.419 |
Arsb | Arsj | ENSMUSP00000088964 | ENSMUSP00000091511 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Arylsulfatase J. | 0.418 |
Arsb | Galns | ENSMUSP00000088964 | ENSMUSP00000015171 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | N-acetylgalactosamine-6-sulfatase; Belongs to the sulfatase family. | 0.506 |
Arsb | Gns | ENSMUSP00000088964 | ENSMUSP00000043167 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | N-acetylglucosamine-6-sulfatase; Belongs to the sulfatase family. | 0.477 |
Arsb | Ids | ENSMUSP00000088964 | ENSMUSP00000099046 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Iduronate 2-sulfatase; Lysosomal enzyme involved in the degradation pathway of dermatan sulfate and heparan sulfate. | 0.484 |
Arsb | Sgsh | ENSMUSP00000088964 | ENSMUSP00000005173 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | N-sulfoglucosamine sulfohydrolase (sulfamidase). | 0.427 |
Arsb | Sumf1 | ENSMUSP00000088964 | ENSMUSP00000032191 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Formylglycine-generating enzyme; Oxidase that catalyzes the conversion of cysteine to 3- oxoalanine on target proteins, using molecular oxygen and an unidentified reducing agent. 3-oxoalanine modification, which is also named formylglycine (fGly), occurs in the maturation of arylsulfatases and some alkaline phosphatases that use the hydrated form of 3- oxoalanine as a catalytic nucleophile. Known substrates include GALNS, ARSA, STS and ARSE; Belongs to the sulfatase-modifying factor family. | 0.881 |
Arsb | Sumf2 | ENSMUSP00000088964 | ENSMUSP00000126036 | Arylsulfatase B; Removes sulfate groups from chondroitin-4-sulfate (C4S) and regulates its degradation (By similarity). Involved in the regulation of cell adhesion, cell migration and invasion in colonic epithelium (By similarity). In the central nervous system, is a regulator of neurite outgrowth and neuronal plasticity, acting through the control of sulfate glycosaminoglycans and neurocan levels (By similarity). Belongs to the sulfatase family. | Inactive C-alpha-formylglycine-generating enzyme 2; Lacks formylglycine generating activity and is unable to convert newly synthesized inactive sulfatases to their active form. Inhibits the activation of sulfatases by SUMF1. Belongs to the sulfatase-modifying factor family. | 0.705 |