node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccr5 | Clec4a2 | ENSMUSP00000107069 | ENSMUSP00000032248 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | 0.564 |
Ccr5 | Tlr8 | ENSMUSP00000107069 | ENSMUSP00000107793 | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | Toll-like receptor 8; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B. activation, cytokine secretion and the inflammatory response (By similarity). | 0.594 |
Clec12a | Clec4a2 | ENSMUSP00000063627 | ENSMUSP00000032248 | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | 0.732 |
Clec12a | Clec4b1 | ENSMUSP00000063627 | ENSMUSP00000077636 | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. | Dendritic cell immuno-activating receptor alpha isoform. | 0.483 |
Clec12a | Clec5a | ENSMUSP00000063627 | ENSMUSP00000121848 | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. | 0.503 |
Clec12a | Ly75 | ENSMUSP00000063627 | ENSMUSP00000028362 | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. | Lymphocyte antigen 75; Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity). | 0.487 |
Clec12a | Nr0b2 | ENSMUSP00000063627 | ENSMUSP00000039175 | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. | Nuclear receptor subfamily 0 group B member 2; Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2- mediated hepatic lipid metabolism. Regulates the [...] | 0.685 |
Clec12a | Ptpn11 | ENSMUSP00000063627 | ENSMUSP00000058757 | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. | 0.946 |
Clec4a2 | Ccr5 | ENSMUSP00000032248 | ENSMUSP00000107069 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | C-C chemokine receptor type 5; Receptor for a number of inflammatory CC-chemokines including MIP-1-alpha, MIP-1-beta and RANTES and subsequently transduces a signal by increasing the intracellular calcium ion level. May play a role in the control of granulocytic lineage proliferation or differentiation (By similarity). | 0.564 |
Clec4a2 | Clec12a | ENSMUSP00000032248 | ENSMUSP00000063627 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. | 0.732 |
Clec4a2 | Clec4b1 | ENSMUSP00000032248 | ENSMUSP00000077636 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | Dendritic cell immuno-activating receptor alpha isoform. | 0.546 |
Clec4a2 | Clec5a | ENSMUSP00000032248 | ENSMUSP00000121848 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. | 0.810 |
Clec4a2 | Clec9a | ENSMUSP00000032248 | ENSMUSP00000056625 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | C-type lectin domain family 9 member A; Functions as an endocytic receptor on a small subset of myeloid cells specialized for the uptake and processing of material from dead cells. Recognizes filamentous form of actin in association with particular actin-binding domains of cytoskeletal proteins, including spectrin, exposed when cell membranes are damaged, and mediate the cross-presentation of dead-cell associated antigens in a Syk-dependent manner. | 0.695 |
Clec4a2 | Fcer1g | ENSMUSP00000032248 | ENSMUSP00000078875 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | High affinity immunoglobulin epsilon receptor subunit gamma; Adapter protein containing an immunoreceptor tyrosine-based activation motif (ITAM) that transduces activation signals from various immunoreceptors. As a component of the high-affinity immunoglobulin E (IgE) receptor, mediates allergic inflammatory signaling in mast cells. As a constitutive component of interleukin-3 receptor complex, selectively mediates interleukin 4/IL4 production by basophils, priming T-cells toward effector T-helper 2 subset. Associates with pattern recognition receptors CLEC4D and CLEC4E to form a funct [...] | 0.574 |
Clec4a2 | Ly75 | ENSMUSP00000032248 | ENSMUSP00000028362 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | Lymphocyte antigen 75; Acts as an endocytic receptor to direct captured antigens from the extracellular space to a specialized antigen-processing compartment. Causes reduced proliferation of B lymphocytes (By similarity). | 0.709 |
Clec4a2 | Nr0b2 | ENSMUSP00000032248 | ENSMUSP00000039175 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | Nuclear receptor subfamily 0 group B member 2; Transcriptional regulator that acts as a negative regulator of receptor-dependent signaling pathways. Specifically inhibits transactivation of the nuclear receptor with which it interacts. Inhibits transcriptional activity of NEUROD1 on E-box-containing promoter by interfering with the coactivation function of the p300/CBP-mediated transcription complex for NEUROD1 (By similarity). Essential component of the liver circadian clock which via its interaction with NR1D1 and RORG regulates NPAS2- mediated hepatic lipid metabolism. Regulates the [...] | 0.544 |
Clec4a2 | Ptpn11 | ENSMUSP00000032248 | ENSMUSP00000058757 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | Tyrosine-protein phosphatase non-receptor type 11; Acts downstream of various receptor and cytoplasmic protein tyrosine kinases to participate in the signal transduction from the cell surface to the nucleus. Positively regulates MAPK signal transduction pathway. Dephosphorylates GAB1, ARHGAP35 and EGFR. Dephosphorylates ROCK2 at 'Tyr-722' resulting in stimulatation of its RhoA binding activity. Dephosphorylates CDC73. | 0.861 |
Clec4a2 | Tlr8 | ENSMUSP00000032248 | ENSMUSP00000107793 | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | Toll-like receptor 8; Key component of innate and adaptive immunity. TLRs (Toll- like receptors) control host immune response against pathogens through recognition of molecular patterns specific to microorganisms. Acts via MYD88 and TRAF6, leading to NF-kappa-B. activation, cytokine secretion and the inflammatory response (By similarity). | 0.569 |
Clec4b1 | Clec12a | ENSMUSP00000077636 | ENSMUSP00000063627 | Dendritic cell immuno-activating receptor alpha isoform. | C-type lectin domain family 12 member A; Cell surface receptor that modulates signaling cascades and mediates tyrosine phosphorylation of target MAP kinases. | 0.483 |
Clec4b1 | Clec4a2 | ENSMUSP00000077636 | ENSMUSP00000032248 | Dendritic cell immuno-activating receptor alpha isoform. | C-type lectin domain family 4 member A; May be involved in regulating immune reactivity. May play a role in modulating dendritic cells (DC) differentiation and/or maturation (By similarity). May be involved in the inhibition of B- cell-receptor-mediated calcium mobilization and protein tyrosine phosphorylation. | 0.546 |