node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Amigo2 | Cd109 | ENSMUSP00000155019 | ENSMUSP00000091330 | Amphoterin-induced protein 2; Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity); Belongs to the immunoglobulin superfamily. AMIGO family. | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | 0.452 |
Amigo2 | Emp1 | ENSMUSP00000155019 | ENSMUSP00000145069 | Amphoterin-induced protein 2; Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity); Belongs to the immunoglobulin superfamily. AMIGO family. | Epithelial membrane protein 1. | 0.525 |
Anxa2 | Emp1 | ENSMUSP00000034756 | ENSMUSP00000145069 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Epithelial membrane protein 1. | 0.592 |
Anxa2 | Vcam1 | ENSMUSP00000034756 | ENSMUSP00000029574 | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. | 0.507 |
Ccnj | Emp1 | ENSMUSP00000025983 | ENSMUSP00000145069 | Cyclin-J. | Epithelial membrane protein 1. | 0.554 |
Ccnj | Gdf15 | ENSMUSP00000025983 | ENSMUSP00000003808 | Cyclin-J. | Growth/differentiation factor 15; Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling. | 0.551 |
Cd109 | Amigo2 | ENSMUSP00000091330 | ENSMUSP00000155019 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | Amphoterin-induced protein 2; Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity); Belongs to the immunoglobulin superfamily. AMIGO family. | 0.452 |
Cd109 | Cd36 | ENSMUSP00000091330 | ENSMUSP00000133008 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependen [...] | 0.496 |
Cd109 | Emp1 | ENSMUSP00000091330 | ENSMUSP00000145069 | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | Epithelial membrane protein 1. | 0.534 |
Cd36 | Cd109 | ENSMUSP00000133008 | ENSMUSP00000091330 | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependen [...] | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | 0.496 |
Cd36 | Emp1 | ENSMUSP00000133008 | ENSMUSP00000145069 | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependen [...] | Epithelial membrane protein 1. | 0.679 |
Cd36 | Vcam1 | ENSMUSP00000133008 | ENSMUSP00000029574 | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependen [...] | Vascular cell adhesion protein 1; Important in cell-cell recognition. Appears to function in leukocyte-endothelial cell adhesion. Interacts with integrin alpha- 4/beta-1 (ITGA4/ITGB1) on leukocytes, and mediates both adhesion and signal transduction. The VCAM1/ITGA4/ITGB1 interaction may play a pathophysiologic role both in immune responses and in leukocyte emigration to sites of inflammation. | 0.781 |
Emp1 | Amigo2 | ENSMUSP00000145069 | ENSMUSP00000155019 | Epithelial membrane protein 1. | Amphoterin-induced protein 2; Required for depolarization-dependent survival of cultured cerebellar granule neurons. May mediate homophilic as well as heterophilic cell-cell interaction with AMIGO1 or AMIGO3. May contribute to signal transduction through its intracellular domain (By similarity); Belongs to the immunoglobulin superfamily. AMIGO family. | 0.525 |
Emp1 | Anxa2 | ENSMUSP00000145069 | ENSMUSP00000034756 | Epithelial membrane protein 1. | Annexin A2; Calcium-regulated membrane-binding protein whose affinity for calcium is greatly enhanced by anionic phospholipids. It binds two calcium ions with high affinity. May be involved in heat-stress response (By similarity). Inhibits PCSK9-enhanced LDLR degradation, probably reduces PCSK9 protein levels via a translational mechanism but also competes with LDLR for binding with PCSK9. Belongs to the annexin family. | 0.592 |
Emp1 | Ccnj | ENSMUSP00000145069 | ENSMUSP00000025983 | Epithelial membrane protein 1. | Cyclin-J. | 0.554 |
Emp1 | Cd109 | ENSMUSP00000145069 | ENSMUSP00000091330 | Epithelial membrane protein 1. | CD109 antigen; Modulates negatively TGFB1 signaling in keratinocytes. | 0.534 |
Emp1 | Cd36 | ENSMUSP00000145069 | ENSMUSP00000133008 | Epithelial membrane protein 1. | Platelet glycoprotein 4; Multifunctional glycoprotein that acts as receptor for a broad range of ligands. Ligands can be of proteinaceous nature like thrombospondin, fibronectin, collagen or amyloid-beta as well as of lipidic nature such as oxidized low-density lipoprotein (oxLDL), anionic phospholipids, long-chain fatty acids and bacterial diacylated lipopeptides. They are generally multivalent and can therefore engage multiple receptors simultaneously, the resulting formation of CD36 clusters initiates signal transduction and internalization of receptor-ligand complexes. The dependen [...] | 0.679 |
Emp1 | Fgf23 | ENSMUSP00000145069 | ENSMUSP00000000186 | Epithelial membrane protein 1. | Fibroblast growth factor 23; Regulator of phosphate homeostasis (By similarity). Inhibits renal tubular phosphate transport by reducing SLC34A1 levels (By similarity). Acts directly on the parathyroid to decrease PTH secretion (By similarity). Regulator of vitamin-D metabolism (By similarity). Negatively regulates osteoblasts differentiation and matrix mineralization (By similarity). Upregulates EGR1 expression in the presence of KL; Belongs to the heparin-binding growth factors family. | 0.561 |
Emp1 | Gdf15 | ENSMUSP00000145069 | ENSMUSP00000003808 | Epithelial membrane protein 1. | Growth/differentiation factor 15; Regulates food intake, energy expenditure and body weight in response to metabolic and toxin-induced stresses. Binds to its receptor, GFRAL, and activates GFRAL-expressing neurons localized in the area postrema and nucleus tractus solitarius of the brainstem. It then triggers the activation of neurons localized within the parabrachial nucleus and central amygdala, which contitutes part of the 'emergency circuit' that shapes feeding responses to stressful conditions. On hepatocytes, inhibits growth hormone signaling. | 0.522 |
Emp1 | Pth | ENSMUSP00000145069 | ENSMUSP00000078723 | Epithelial membrane protein 1. | Parathyroid hormone; PTH elevates calcium level by dissolving the salts in bone and preventing their renal excretion; Belongs to the parathyroid hormone family. | 0.599 |