node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fan1 | Klf13 | ENSMUSP00000130012 | ENSMUSP00000067680 | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flankin [...] | Krueppel-like factor 13; Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage. | 0.441 |
Fan1 | Mtmr10 | ENSMUSP00000130012 | ENSMUSP00000032736 | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flankin [...] | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.809 |
Fan1 | Otud7a | ENSMUSP00000130012 | ENSMUSP00000057282 | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flankin [...] | OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. | 0.558 |
Fan1 | Trpm1 | ENSMUSP00000130012 | ENSMUSP00000082318 | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flankin [...] | Transient receptor potential cation channel subfamily M member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel; Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. | 0.439 |
Klf13 | Fan1 | ENSMUSP00000067680 | ENSMUSP00000130012 | Krueppel-like factor 13; Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage. | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flankin [...] | 0.441 |
Klf13 | Mtmr10 | ENSMUSP00000067680 | ENSMUSP00000032736 | Krueppel-like factor 13; Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage. | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.725 |
Klf13 | Otud7a | ENSMUSP00000067680 | ENSMUSP00000057282 | Krueppel-like factor 13; Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage. | OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. | 0.651 |
Klf13 | Trpm1 | ENSMUSP00000067680 | ENSMUSP00000082318 | Krueppel-like factor 13; Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage. | Transient receptor potential cation channel subfamily M member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel; Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. | 0.413 |
Lrguk | Mtmr10 | ENSMUSP00000065146 | ENSMUSP00000032736 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.525 |
Ly6g6c | Mtmr10 | ENSMUSP00000133510 | ENSMUSP00000032736 | Lymphocyte antigen 6 complex locus protein G6c. | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.538 |
Mtmr10 | Fan1 | ENSMUSP00000032736 | ENSMUSP00000130012 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Fanconi-associated nuclease 1; Nuclease required for the repair of DNA interstrand cross- links (ICL) recruited at sites of DNA damage by monoubiquitinated FANCD2. Specifically involved in repair of ICL-induced DNA breaks by being required for efficient homologous recombination, probably in the resolution of homologous recombination intermediates (By similarity). Not involved in DNA double-strand breaks resection. Acts as a 5'-3' exonuclease that anchors at a cut end of DNA and cleaves DNA successively at every third nucleotide, allowing to excise an ICL from one strand through flankin [...] | 0.809 |
Mtmr10 | Klf13 | ENSMUSP00000032736 | ENSMUSP00000067680 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Krueppel-like factor 13; Transcription factor that activates expression from GC-rich minimal promoter regions, including genes in the cells of the erythroid lineage. | 0.725 |
Mtmr10 | Lrguk | ENSMUSP00000032736 | ENSMUSP00000065146 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.525 |
Mtmr10 | Ly6g6c | ENSMUSP00000032736 | ENSMUSP00000133510 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Lymphocyte antigen 6 complex locus protein G6c. | 0.538 |
Mtmr10 | Mtmr2 | ENSMUSP00000032736 | ENSMUSP00000034396 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Myotubularin-related protein 2; Phosphatase that acts on lipids with a phosphoinositol headgroup. Has phosphatase activity towards pho sphatidylinositol 3-phosphate and phosphatidylinositol 3,5- bisphosphate. Binds phosphatidylinositol 4-phosphate, phosphatidylinositol 5-phosphate, phosphatidylinositol 3,5-bisphosphate and phosphatidylinositol 3,4,5- trisphosphate. Stabilizes SBF2/MTMR13 at the membranes. Specifically in peripheral nerves, stabilizes SBF2/MTMR13 protein. Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | 0.558 |
Mtmr10 | Otud7a | ENSMUSP00000032736 | ENSMUSP00000057282 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | OTU domain-containing protein 7A; Has deubiquitinating activity towards 'Lys-11'-linked polyubiquitin chains. | 0.836 |
Mtmr10 | Pqlc3 | ENSMUSP00000032736 | ENSMUSP00000054462 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Solute carrier family 66 member 3. | 0.454 |
Mtmr10 | Rassf9 | ENSMUSP00000032736 | ENSMUSP00000151843 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Ras association domain-containing protein 9; May play a role in regulating vesicuar trafficking in cells. | 0.512 |
Mtmr10 | Trpm1 | ENSMUSP00000032736 | ENSMUSP00000082318 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | Transient receptor potential cation channel subfamily M member 1; Cation channel essential for the depolarizing photoresponse of retinal ON bipolar cells. It is part of the GRM6 signaling cascade. Calcium channel which may play a role in metastasis suppression. May act as a spontaneously active, calcium-permeable plasma membrane channel; Belongs to the transient receptor (TC 1.A.4) family. LTrpC subfamily. TRPM1 sub-subfamily. | 0.686 |
Mtmr10 | Wdr91 | ENSMUSP00000032736 | ENSMUSP00000079974 | Myotubularin-related protein 10; Belongs to the protein-tyrosine phosphatase family. Non- receptor class myotubularin subfamily. | WD repeat-containing protein 91; Functions as a negative regulator of the PI3 kinase/PI3K activity associated with endosomal membranes via BECN1, a core subunit of the PI3K complex. By modifying the phosphatidylinositol 3- phosphate/PtdInsP3 content of endosomal membranes may regulate endosome fusion, recycling, sorting and early to late endosome transport. It is for instance, required for the delivery of cargos like BST2/tetherin from early to late endosome and thereby participates indirectly to their degradation by the lysosome (By similarity). May play a role in meiosis. | 0.473 |