node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgap30 | Arhgap9 | ENSMUSP00000059389 | ENSMUSP00000151574 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | Rho GTPase-activating protein 9. | 0.536 |
Arhgap30 | Laptm5 | ENSMUSP00000059389 | ENSMUSP00000118415 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | 0.678 |
Arhgap30 | Nckap1l | ENSMUSP00000059389 | ENSMUSP00000035400 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | Nck-associated protein 1-like; Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells. Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Al [...] | 0.743 |
Arhgap30 | Ptprc | ENSMUSP00000059389 | ENSMUSP00000138350 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. | 0.611 |
Arhgap30 | Rasal3 | ENSMUSP00000059389 | ENSMUSP00000123141 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway. | 0.426 |
Arhgap30 | Sash3 | ENSMUSP00000059389 | ENSMUSP00000033427 | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | 0.734 |
Arhgap9 | Arhgap30 | ENSMUSP00000151574 | ENSMUSP00000059389 | Rho GTPase-activating protein 9. | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | 0.536 |
Arhgap9 | Nckap1l | ENSMUSP00000151574 | ENSMUSP00000035400 | Rho GTPase-activating protein 9. | Nck-associated protein 1-like; Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells. Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Al [...] | 0.436 |
Arhgap9 | Rasal3 | ENSMUSP00000151574 | ENSMUSP00000123141 | Rho GTPase-activating protein 9. | RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway. | 0.417 |
Arhgap9 | Sash3 | ENSMUSP00000151574 | ENSMUSP00000033427 | Rho GTPase-activating protein 9. | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | 0.661 |
Arhgap9 | Selplg | ENSMUSP00000151574 | ENSMUSP00000098436 | Rho GTPase-activating protein 9. | P-selectin glycoprotein ligand 1; A SLe(x)-type proteoglycan, which through high affinity, calcium-dependent interactions with E- and P-selectins, mediates rapid rolling of leukocytes over vascular surfaces during the initial steps in inflammation. Critical for the initial leukocyte capture. | 0.409 |
Bet1 | Sash3 | ENSMUSP00000044877 | ENSMUSP00000033427 | BET1 homolog; Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER- derived vesicles with the cis-Golgi membrane (By similarity). | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | 0.738 |
Bet1 | Vps45 | ENSMUSP00000044877 | ENSMUSP00000015891 | BET1 homolog; Required for vesicular transport from the ER to the Golgi complex. Functions as a SNARE involved in the docking process of ER- derived vesicles with the cis-Golgi membrane (By similarity). | Vacuolar protein sorting-associated protein 45; May play a role in vesicle-mediated protein trafficking from the Golgi stack through the trans-Golgi network. | 0.521 |
Klhl6 | Ptprc | ENSMUSP00000053023 | ENSMUSP00000138350 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. | 0.434 |
Klhl6 | Sash3 | ENSMUSP00000053023 | ENSMUSP00000033427 | Kelch-like protein 6; Involved in B-lymphocyte antigen receptor signaling and germinal center formation. | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | 0.664 |
Laptm5 | Arhgap30 | ENSMUSP00000118415 | ENSMUSP00000059389 | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | Rho GTPase-activating protein 30; GTPase-activating protein (GAP) for RAC1 and RHOA, but not for CDC42. | 0.678 |
Laptm5 | Nckap1l | ENSMUSP00000118415 | ENSMUSP00000035400 | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | Nck-associated protein 1-like; Essential hematopoietic-specific regulator of the actin cytoskeleton. Controls lymphocyte development, activation, proliferation and homeostasis, erythrocyte membrane stability, as well as phagocytosis and migration by neutrophils and macrophages. Component of the WAVE2 complex which signals downstream of RAC to stimulate F-actin polymerization. Required for stabilization and/or translation of the WAVE2 complex proteins in hematopoietic cells. Exhibits complex cycles of activation and inhibition to generate waves of propagating the assembly with actin. Al [...] | 0.872 |
Laptm5 | Ptprc | ENSMUSP00000118415 | ENSMUSP00000138350 | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | Receptor-type tyrosine-protein phosphatase C; Protein tyrosine-protein phosphatase required for T-cell activation through the antigen receptor. Acts as a positive regulator of T-cell coactivation upon binding to DPP4. The first PTPase domain has enzymatic activity, while the second one seems to affect the substrate specificity of the first one. Upon T-cell activation, recruits and dephosphorylates SKAP1 and FYN (By similarity). Dephosphorylates LYN, and thereby modulates LYN activity. | 0.573 |
Laptm5 | Rasal3 | ENSMUSP00000118415 | ENSMUSP00000123141 | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | RAS protein activator like-3; Functions as a Ras GTPase-activating protein. Plays an important role in the expansion and functions of natural killer T (NKT) cells in the liver by negatively regulating RAS activity and the down- stream ERK signaling pathway. | 0.536 |
Laptm5 | Sash3 | ENSMUSP00000118415 | ENSMUSP00000033427 | Lysosomal-associated transmembrane protein 5; May have a special functional role during embryogenesis and in adult hematopoietic cells; Belongs to the LAPTM4/LAPTM5 transporter family. | SAM and SH3 domain-containing protein 3; May function as a signaling adapter protein in lymphocytes. | 0.733 |