node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cog3 | Slc25a14 | ENSMUSP00000045016 | ENSMUSP00000110586 | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.699 |
Gpr101 | Slc25a14 | ENSMUSP00000058183 | ENSMUSP00000110586 | Probable G-protein coupled receptor 101; Orphan receptor. | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.446 |
Mrpl15 | Slc25a14 | ENSMUSP00000115512 | ENSMUSP00000110586 | 39S ribosomal protein L15, mitochondrial. | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.523 |
Park7 | Slc25a14 | ENSMUSP00000101299 | ENSMUSP00000110586 | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.491 |
Park7 | Slc25a27 | ENSMUSP00000101299 | ENSMUSP00000024705 | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | Solute carrier family 25, member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.538 |
Rbmx2 | Slc25a14 | ENSMUSP00000033433 | ENSMUSP00000110586 | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.592 |
Slc25a14 | Cog3 | ENSMUSP00000110586 | ENSMUSP00000045016 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Conserved oligomeric Golgi complex subunit 3; Involved in ER-Golgi transport. | 0.699 |
Slc25a14 | Gpr101 | ENSMUSP00000110586 | ENSMUSP00000058183 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Probable G-protein coupled receptor 101; Orphan receptor. | 0.446 |
Slc25a14 | Mrpl15 | ENSMUSP00000110586 | ENSMUSP00000115512 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 39S ribosomal protein L15, mitochondrial. | 0.523 |
Slc25a14 | Park7 | ENSMUSP00000110586 | ENSMUSP00000101299 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | 0.491 |
Slc25a14 | Rbmx2 | ENSMUSP00000110586 | ENSMUSP00000033433 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | RNA-binding motif protein, X-linked 2; Involved in pre-mRNA splicing as component of the activated spliceosome. | 0.592 |
Slc25a14 | Slc25a27 | ENSMUSP00000110586 | ENSMUSP00000024705 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Solute carrier family 25, member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.487 |
Slc25a14 | Tent5d | ENSMUSP00000110586 | ENSMUSP00000129483 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Terminal nucleotidyltransferase 5D. | 0.453 |
Slc25a14 | Ucp1 | ENSMUSP00000110586 | ENSMUSP00000034146 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.473 |
Slc25a14 | Ucp2 | ENSMUSP00000110586 | ENSMUSP00000120967 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.464 |
Slc25a14 | Ucp3 | ENSMUSP00000110586 | ENSMUSP00000032958 | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial uncoupling protein 3; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation. As a result, energy is dissipated in the form of heat. May play a role in the modulation of tissue respiratory control. Participates in thermogenesis and energy balance (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.462 |
Slc25a27 | Park7 | ENSMUSP00000024705 | ENSMUSP00000101299 | Solute carrier family 25, member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Protein/nucleic acid deglycase DJ-1; Protein and nucleotide deglycase that catalyzes the deglycation of the Maillard adducts formed between amino groups of proteins or nucleotides and reactive carbonyl groups of glyoxals. Thus, functions as a protein deglycase that repairs methylglyoxal- and glyoxal-glycated proteins, and releases repaired proteins and lactate or glycolate, respectively. Deglycates cysteine, arginine and lysine residues in proteins, and thus reactivates these proteins by reversing glycation by glyoxals. Acts on early glycation intermediates (hemithioacetals and aminoca [...] | 0.538 |
Slc25a27 | Slc25a14 | ENSMUSP00000024705 | ENSMUSP00000110586 | Solute carrier family 25, member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Brain mitochondrial carrier protein 1; Participates in the mitochondrial proton leak measured in brain mitochondria; Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.487 |
Slc25a27 | Ucp1 | ENSMUSP00000024705 | ENSMUSP00000034146 | Solute carrier family 25, member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial brown fat uncoupling protein 1; Mitochondrial protein responsible for thermogenic respiration, a specialized capacity of brown adipose tissue and beige fat that participates to non-shivering adaptive thermogenesis to temperature and diet variations and more generally to the regulation of energy balance. Functions as a long-chain fatty acid/LCFA and proton symporter, simultaneously transporting one LCFA and one proton through the inner mitochondrial membrane. However, LCFAs remaining associated with the transporter via their hydrophobic tails, it results in an apparent tra [...] | 0.473 |
Slc25a27 | Ucp2 | ENSMUSP00000024705 | ENSMUSP00000120967 | Solute carrier family 25, member 27; Belongs to the mitochondrial carrier (TC 2.A.29) family. | Mitochondrial uncoupling protein 2; UCP are mitochondrial transporter proteins that create proton leaks across the inner mitochondrial membrane, thus uncoupling oxidative phosphorylation from ATP synthesis. As a result, energy is dissipated in the form of heat (By similarity); Belongs to the mitochondrial carrier (TC 2.A.29) family. | 0.655 |