node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Apool | Rps6ka6 | ENSMUSP00000026599 | ENSMUSP00000080694 | MICOS complex subunit Mic27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | 0.463 |
Apool | Satl1 | ENSMUSP00000026599 | ENSMUSP00000026601 | MICOS complex subunit Mic27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | Spermidine/spermine N(1)-acetyltransferase-like protein 1; Belongs to the acetyltransferase family. | 0.466 |
Apool | Sh3bgrl | ENSMUSP00000026599 | ENSMUSP00000033598 | MICOS complex subunit Mic27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.640 |
Cmtm6 | Sh3bgrl | ENSMUSP00000035007 | ENSMUSP00000033598 | CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...] | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.494 |
Cpxcr1 | Sh3bgrl | ENSMUSP00000098827 | ENSMUSP00000033598 | CPX chromosomal region candidate gene 1 protein homolog. | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.487 |
Egfr | Sh3bgrl | ENSMUSP00000020329 | ENSMUSP00000033598 | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.575 |
Pbdc1 | Sh3bgrl | ENSMUSP00000033577 | ENSMUSP00000033598 | Protein PBDC1. | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.537 |
Rab7b | Sh3bgrl | ENSMUSP00000065456 | ENSMUSP00000033598 | Ras-related protein Rab-7b; Controls vesicular trafficking from endosomes to the trans- Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation [...] | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.580 |
Rps6ka6 | Apool | ENSMUSP00000080694 | ENSMUSP00000026599 | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | MICOS complex subunit Mic27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | 0.463 |
Rps6ka6 | Sh3bgrl | ENSMUSP00000080694 | ENSMUSP00000033598 | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.503 |
Rps6ka6 | Tmem150a | ENSMUSP00000080694 | ENSMUSP00000063977 | Ribosomal protein S6 kinase alpha-6; Constitutively active serine/threonine-protein kinase that exhibits growth-factor-independent kinase activity and that may participate in p53/TP53-dependent cell growth arrest signaling and play an inhibitory role during embryogenesis. | Transmembrane protein 150A; Regulates localization of phosphatidylinositol 4-kinase (PI4K) to the plasma membrane, possibly by reducing the association of TTC7 (TTC7A or TTC7B) with the PI4K complex. Acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). May also play a role in fasting-induced catabolism (By similarity). | 0.482 |
Satl1 | Apool | ENSMUSP00000026601 | ENSMUSP00000026599 | Spermidine/spermine N(1)-acetyltransferase-like protein 1; Belongs to the acetyltransferase family. | MICOS complex subunit Mic27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | 0.466 |
Satl1 | Sh3bgrl | ENSMUSP00000026601 | ENSMUSP00000033598 | Spermidine/spermine N(1)-acetyltransferase-like protein 1; Belongs to the acetyltransferase family. | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.495 |
Selenoo | Sh3bgrl | ENSMUSP00000081020 | ENSMUSP00000033598 | Protein adenylyltransferase SelO, mitochondrial; Catalyzes the transfer of adenosine 5'-monophosphate (AMP) to Ser, Thr and Tyr residues of target proteins (AMPylation). May be a redox-active mitochondrial selenoprotein which interacts with a redox target protein; Belongs to the SELO family. | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.580 |
Sh3bgrl | Apool | ENSMUSP00000033598 | ENSMUSP00000026599 | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | MICOS complex subunit Mic27; Component of the MICOS complex, a large protein complex of the mitochondrial inner membrane that plays crucial roles in the maintenance of crista junctions, inner membrane architecture, and formation of contact sites to the outer membrane. Specifically binds to cardiolipin (in vitro) but not to the precursor lipid phosphatidylglycerol. Plays a crucial role in crista junction formation and mitochondrial function. | 0.640 |
Sh3bgrl | Cmtm6 | ENSMUSP00000033598 | ENSMUSP00000035007 | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | CKLF-like MARVEL transmembrane domain-containing protein 6; Master regulator of recycling and plasma membrane expression of PD-L1/CD274, an immune inhibitory ligand critical for immune tolerance to self and antitumor immunity. Associates with both constitutive and IFNG-induced PD-L1/CD274 at recycling endosomes, where it protects PD-L1/CD274 from being targeted for lysosomal degradation, likely by preventing its ubiquitination. May stabilize PD-L1/CD274 expression on antigen presenting cells and potentiates inhibitory signaling by PDCD1/CD279, its receptor on T-cells, ultimately trigge [...] | 0.494 |
Sh3bgrl | Cpxcr1 | ENSMUSP00000033598 | ENSMUSP00000098827 | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | CPX chromosomal region candidate gene 1 protein homolog. | 0.487 |
Sh3bgrl | Egfr | ENSMUSP00000033598 | ENSMUSP00000020329 | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | Epidermal growth factor receptor; Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses. Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF. Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least [...] | 0.575 |
Sh3bgrl | Pbdc1 | ENSMUSP00000033598 | ENSMUSP00000033577 | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | Protein PBDC1. | 0.537 |
Sh3bgrl | Rab7b | ENSMUSP00000033598 | ENSMUSP00000065456 | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | Ras-related protein Rab-7b; Controls vesicular trafficking from endosomes to the trans- Golgi network (TGN). Acts as a negative regulator of TLR9 signaling and can suppress TLR9-triggered TNFA, IL6, and IFNB production in macrophages by promoting TLR9 lysosomal degradation. Also negatively regulates TLR4 signaling in macrophages by promoting lysosomal degradation of TLR4. Promotes megakaryocytic differentiation by increasing NF-kappa-B-dependent IL6 production and subsequently enhancing the association of STAT3 with GATA1. Not involved in the regulation of the EGF- and EGFR degradation [...] | 0.580 |