node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Btbd16 | Cdx4 | ENSMUSP00000035433 | ENSMUSP00000033689 | BTB/POZ domain-containing protein 16. | Homeobox protein CDX-4. | 0.468 |
Cdx4 | Btbd16 | ENSMUSP00000033689 | ENSMUSP00000035433 | Homeobox protein CDX-4. | BTB/POZ domain-containing protein 16. | 0.468 |
Cdx4 | Chic1 | ENSMUSP00000033689 | ENSMUSP00000112246 | Homeobox protein CDX-4. | Cysteine-rich hydrophobic domain-containing protein 1; Belongs to the CHIC family. | 0.653 |
Cdx4 | Fgf4 | ENSMUSP00000033689 | ENSMUSP00000056752 | Homeobox protein CDX-4. | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis; Belongs to the heparin-binding growth factors family. | 0.597 |
Cdx4 | Mixl1 | ENSMUSP00000033689 | ENSMUSP00000027778 | Homeobox protein CDX-4. | Homeobox protein MIXL1; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. | 0.490 |
Cdx4 | Ogg1 | ENSMUSP00000033689 | ENSMUSP00000032406 | Homeobox protein CDX-4. | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion; Belongs to the type-1 OGG1 family. | 0.518 |
Cdx4 | Prr16 | ENSMUSP00000033689 | ENSMUSP00000112338 | Homeobox protein CDX-4. | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration (Probable). | 0.480 |
Cdx4 | Slc16a2 | ENSMUSP00000033689 | ENSMUSP00000037629 | Homeobox protein CDX-4. | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.516 |
Cdx4 | T | ENSMUSP00000033689 | ENSMUSP00000074236 | Homeobox protein CDX-4. | T-box transcription factor T; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. | 0.508 |
Cdx4 | Tbpl2 | ENSMUSP00000033689 | ENSMUSP00000079309 | Homeobox protein CDX-4. | TATA box-binding protein-like protein 2; Transcription factor required in complex with TAF3 for the differentiation of myoblasts into myocytes. The complex replaces TFIID at specific promoters at an early stage in the differentiation process. | 0.578 |
Cdx4 | Timp2 | ENSMUSP00000033689 | ENSMUSP00000017610 | Homeobox protein CDX-4. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.476 |
Chic1 | Cdx4 | ENSMUSP00000112246 | ENSMUSP00000033689 | Cysteine-rich hydrophobic domain-containing protein 1; Belongs to the CHIC family. | Homeobox protein CDX-4. | 0.653 |
Chic1 | Slc16a2 | ENSMUSP00000112246 | ENSMUSP00000037629 | Cysteine-rich hydrophobic domain-containing protein 1; Belongs to the CHIC family. | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | 0.594 |
Fgf4 | Cdx4 | ENSMUSP00000056752 | ENSMUSP00000033689 | Fibroblast growth factor 4; Plays an important role in the regulation of embryonic development, cell proliferation, and cell differentiation. Is essential for survival of the postimplantation mouse embryo. Required for normal limb and cardiac valve development during embryogenesis; Belongs to the heparin-binding growth factors family. | Homeobox protein CDX-4. | 0.597 |
Mixl1 | Cdx4 | ENSMUSP00000027778 | ENSMUSP00000033689 | Homeobox protein MIXL1; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. | Homeobox protein CDX-4. | 0.490 |
Mixl1 | T | ENSMUSP00000027778 | ENSMUSP00000074236 | Homeobox protein MIXL1; Transcription factor that play a central role in proper axial mesendoderm morphogenesis and endoderm formation. Required for efficient differentiation of cells from the primitive streak stage to blood, by acting early in the recruitment and/or expansion of mesodermal progenitors to the hemangioblastic and hematopoietic lineages. Also involved in the morphogenesis of the heart and the gut during embryogenesis. Acts as a negative regulator of brachyury expression. | T-box transcription factor T; Involved in the transcriptional regulation of genes required for mesoderm formation and differentiation. Binds to a palindromic site (called T site) and activates gene transcription when bound to such a site. | 0.869 |
Ogg1 | Cdx4 | ENSMUSP00000032406 | ENSMUSP00000033689 | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion; Belongs to the type-1 OGG1 family. | Homeobox protein CDX-4. | 0.518 |
Ogg1 | Timp2 | ENSMUSP00000032406 | ENSMUSP00000017610 | DNA-(apurinic or apyrimidinic site) lyase; DNA repair enzyme that incises DNA at 8-oxoG residues. Excises 7,8-dihydro-8-oxoguanine and 2,6-diamino-4-hydroxy-5-N- methylformamidopyrimidine (FAPY) from damaged DNA. Has a beta-lyase activity that nicks DNA 3' to the lesion; Belongs to the type-1 OGG1 family. | Metalloproteinase inhibitor 2; Complexes with metalloproteinases (such as collagenases) and irreversibly inactivates them by binding to their catalytic zinc cofactor; Belongs to the protease inhibitor I35 (TIMP) family. | 0.514 |
Prr16 | Cdx4 | ENSMUSP00000112338 | ENSMUSP00000033689 | Protein Largen; Regulator of cell size that promotes cell size increase independently of mTOR and Hippo signaling pathways. Acts by stimulating the translation of specific mRNAs, including those encoding proteins affecting mitochondrial functions. Increases mitochondrial mass and respiration (Probable). | Homeobox protein CDX-4. | 0.480 |
Slc16a2 | Cdx4 | ENSMUSP00000037629 | ENSMUSP00000033689 | Monocarboxylate transporter 8; Very active and specific thyroid hormone transporter. Stimulates cellular uptake of thyroxine (T4), triiodothyronine (T3), reverse triiodothyronine (rT3) and diidothyronine. Does not transport Leu, Phe, Trp or Tyr; Belongs to the major facilitator superfamily. Monocarboxylate porter (TC 2.A.1.13) family. | Homeobox protein CDX-4. | 0.516 |