node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Dennd5b | Itfg1 | ENSMUSP00000107182 | ENSMUSP00000034140 | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity); Belongs to the RAB6IP1 family. | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | 0.588 |
Dennd5b | Slc24a3 | ENSMUSP00000107182 | ENSMUSP00000079897 | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity); Belongs to the RAB6IP1 family. | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.569 |
Dennd5b | Zmat4 | ENSMUSP00000107182 | ENSMUSP00000049430 | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity); Belongs to the RAB6IP1 family. | Zinc finger matrin-type protein 4. | 0.580 |
Itfg1 | Dennd5b | ENSMUSP00000034140 | ENSMUSP00000107182 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity); Belongs to the RAB6IP1 family. | 0.588 |
Itfg1 | Mcm2 | ENSMUSP00000034140 | ENSMUSP00000061923 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | DNA replication licensing factor MCM2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | 0.551 |
Itfg1 | Phkb | ENSMUSP00000034140 | ENSMUSP00000050788 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | Phosphorylase b kinase regulatory subunit beta; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity). | 0.578 |
Itfg1 | Slc24a3 | ENSMUSP00000034140 | ENSMUSP00000079897 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | 0.552 |
Itfg1 | Soga1 | ENSMUSP00000034140 | ENSMUSP00000066556 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | C-terminal 80 kDa form; Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. Belongs to the SOGA family. | 0.461 |
Itfg1 | Tmem179b | ENSMUSP00000034140 | ENSMUSP00000010249 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | Transmembrane protein 179B. | 0.626 |
Itfg1 | Tmem30a | ENSMUSP00000034140 | ENSMUSP00000034878 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | Cell cycle control protein 50A; Accessory component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids from the outer to the inner leaflet of various membranes and ensures the maintenance of asymmetric distribution of phospholipids. Phospholipid translocation seems also to be implicated in vesicle formation and in uptake of lipid signaling molecules. The beta subunit may assist in binding of the phospholipid substrate. Required for the proper folding, assembly and ER to Golgi exit of the ATP8A2:TMEM30A flippase complex. [...] | 0.568 |
Itfg1 | Yipf1 | ENSMUSP00000034140 | ENSMUSP00000075113 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | Protein YIPF1; Belongs to the YIP1 family. | 0.488 |
Itfg1 | Zmat4 | ENSMUSP00000034140 | ENSMUSP00000049430 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | Zinc finger matrin-type protein 4. | 0.471 |
Itfg1 | Zmynd19 | ENSMUSP00000034140 | ENSMUSP00000028350 | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | Zinc finger MYND domain-containing protein 19; May be involved as a regulatory molecule in GPR24/MCH-R1 signaling. | 0.473 |
Mcm2 | Itfg1 | ENSMUSP00000061923 | ENSMUSP00000034140 | DNA replication licensing factor MCM2; Acts as component of the MCM2-7 complex (MCM complex) which is the putative replicative helicase essential for 'once per cell cycle' DNA replication initiation and elongation in eukaryotic cells. The active ATPase sites in the MCM2-7 ring are formed through the interaction surfaces of two neighboring subunits such that a critical structure of a conserved arginine finger motif is provided in trans relative to the ATP-binding site of the Walker A box of the adjacent subunit. The six ATPase active sites, however, are likely to contribute differential [...] | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | 0.551 |
Phkb | Itfg1 | ENSMUSP00000050788 | ENSMUSP00000034140 | Phosphorylase b kinase regulatory subunit beta; Phosphorylase b kinase catalyzes the phosphorylation of serine in certain substrates, including troponin I. The beta chain acts as a regulatory unit and modulates the activity of the holoenzyme in response to phosphorylation (By similarity). | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | 0.578 |
Slc24a3 | Dennd5b | ENSMUSP00000079897 | ENSMUSP00000107182 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | DENN domain-containing protein 5B; Guanine nucleotide exchange factor (GEF) which may activate RAB39A and/or RAB39B. Promotes the exchange of GDP to GTP, converting inactive GDP-bound Rab proteins into their active GTP-bound form (By similarity); Belongs to the RAB6IP1 family. | 0.569 |
Slc24a3 | Itfg1 | ENSMUSP00000079897 | ENSMUSP00000034140 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | 0.552 |
Slc24a3 | Zmat4 | ENSMUSP00000079897 | ENSMUSP00000049430 | Sodium/potassium/calcium exchanger 3; Transports 1 Ca(2+) and 1 K(+) in exchange for 4 Na(+). | Zinc finger matrin-type protein 4. | 0.417 |
Soga1 | Itfg1 | ENSMUSP00000066556 | ENSMUSP00000034140 | C-terminal 80 kDa form; Regulates autophagy by playing a role in the reduction of glucose production in an adiponectin- and insulin-dependent manner. Belongs to the SOGA family. | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | 0.461 |
Tmem179b | Itfg1 | ENSMUSP00000010249 | ENSMUSP00000034140 | Transmembrane protein 179B. | T-cell immunomodulatory protein; Modulator of T-cell function. Has a protective effect in graft versus host disease model. | 0.626 |