node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cda | Ces1e | ENSMUSP00000030535 | ENSMUSP00000034173 | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | 0.905 |
Ces1e | Cda | ENSMUSP00000034173 | ENSMUSP00000030535 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis. | 0.905 |
Ces1e | Cyp2e1 | ENSMUSP00000034173 | ENSMUSP00000026552 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | 0.919 |
Ces1e | Gusb | ENSMUSP00000034173 | ENSMUSP00000026613 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates. | 0.938 |
Ces1e | Mpo | ENSMUSP00000034173 | ENSMUSP00000020779 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | Myeloperoxidase heavy chain; Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity; Belongs to the peroxidase family. XPO subfamily. | 0.908 |
Ces1e | Nat1 | ENSMUSP00000034173 | ENSMUSP00000026677 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | Arylamine N-acetyltransferase 1; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Isoniazid, 2-aminofluorene and anisidine are preferred substrates for NAT-1. No activity with p-aminobenzoic acid (PABA) nor SMZ. | 0.907 |
Ces1e | Nat2 | ENSMUSP00000034173 | ENSMUSP00000130065 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | Arylamine N-acetyltransferase 2; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. 2-aminofluorene and p-aminobenzoic acid (PABA) are preferred substrates for NAT-2. Less activity with anisidine and barely detectable with SMZ. | 0.907 |
Ces1e | Nat3 | ENSMUSP00000034173 | ENSMUSP00000069359 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | Arylamine N-acetyltransferase 3; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. | 0.903 |
Ces1e | Ugt2a3 | ENSMUSP00000034173 | ENSMUSP00000031195 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family. | 0.781 |
Ces1e | Ugt2b1 | ENSMUSP00000034173 | ENSMUSP00000031183 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.769 |
Ces1e | Ugt2b5 | ENSMUSP00000034173 | ENSMUSP00000068282 | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. | 0.755 |
Cyp2e1 | Ces1e | ENSMUSP00000026552 | ENSMUSP00000034173 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | 0.919 |
Cyp2e1 | Nat1 | ENSMUSP00000026552 | ENSMUSP00000026677 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Arylamine N-acetyltransferase 1; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. Isoniazid, 2-aminofluorene and anisidine are preferred substrates for NAT-1. No activity with p-aminobenzoic acid (PABA) nor SMZ. | 0.923 |
Cyp2e1 | Nat2 | ENSMUSP00000026552 | ENSMUSP00000130065 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Arylamine N-acetyltransferase 2; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. 2-aminofluorene and p-aminobenzoic acid (PABA) are preferred substrates for NAT-2. Less activity with anisidine and barely detectable with SMZ. | 0.942 |
Cyp2e1 | Nat3 | ENSMUSP00000026552 | ENSMUSP00000069359 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | Arylamine N-acetyltransferase 3; Participates in the detoxification of a plethora of hydrazine and arylamine drugs. | 0.926 |
Cyp2e1 | Ugt2a3 | ENSMUSP00000026552 | ENSMUSP00000031195 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family. | 0.969 |
Cyp2e1 | Ugt2b1 | ENSMUSP00000026552 | ENSMUSP00000031183 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family. | 0.965 |
Cyp2e1 | Ugt2b5 | ENSMUSP00000026552 | ENSMUSP00000068282 | Cytochrome P450 2E1; A cytochrome P450 monooxygenase involved in the metabolism of fatty acids. Mechanistically, uses molecular oxygen inserting one oxygen atom into a substrate, and reducing the second into a water molecule, with two electrons provided by NADPH via cytochrome P450 reductase (NADPH--hemoprotein reductase). Catalyzes the hydroxylation of carbon-hydrogen bonds. Hydroxylates fatty acids specifically at the omega-1 position displaying the highest catalytic activity for saturated fatty acids. May be involved in the oxidative metabolism of xenobiotics. | UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds. | 0.949 |
Gusb | Ces1e | ENSMUSP00000026613 | ENSMUSP00000034173 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates. | Carboxylesterase 1E; Involved in the detoxification of xenobiotics and in the activation of ester and amide prodrugs. | 0.938 |
Gusb | Mpo | ENSMUSP00000026613 | ENSMUSP00000020779 | Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates. | Myeloperoxidase heavy chain; Part of the host defense system of polymorphonuclear leukocytes. It is responsible for microbicidal activity against a wide range of organisms. In the stimulated PMN, MPO catalyzes the production of hypohalous acids, primarily hypochlorous acid in physiologic situations, and other toxic intermediates that greatly enhance PMN microbicidal activity; Belongs to the peroxidase family. XPO subfamily. | 0.634 |