node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arl2bp | Cfap20 | ENSMUSP00000034228 | ENSMUSP00000034249 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | 0.737 |
Arl2bp | Tbc1d32 | ENSMUSP00000034228 | ENSMUSP00000097328 | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). | Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling. | 0.430 |
Cfap20 | Arl2bp | ENSMUSP00000034249 | ENSMUSP00000034228 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | ADP-ribosylation factor-like protein 2-binding protein; Together with ARL2, plays a role in the nuclear translocation, retention and transcriptional activity of STAT3. May play a role as an effector of ARL2 (By similarity). | 0.737 |
Cfap20 | Cfap298 | ENSMUSP00000034249 | ENSMUSP00000023694 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity. | 0.742 |
Cfap20 | Cfap45 | ENSMUSP00000034249 | ENSMUSP00000083057 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | Cilia and flagella-associated protein 45. | 0.700 |
Cfap20 | Cfap52 | ENSMUSP00000034249 | ENSMUSP00000021287 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. | 0.687 |
Cfap20 | Efhc1 | ENSMUSP00000034249 | ENSMUSP00000042343 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death. Overexpression of EFHC1 in hippocampal primary culture neurons induced apoptosis. | 0.727 |
Cfap20 | Efhc2 | ENSMUSP00000034249 | ENSMUSP00000026014 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | EF-hand domain-containing family member C2. | 0.725 |
Cfap20 | Fahd2a | ENSMUSP00000034249 | ENSMUSP00000028848 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | Fumarylacetoacetate hydrolase domain-containing protein 2A; May have hydrolase activity. | 0.740 |
Cfap20 | Pacrg | ENSMUSP00000034249 | ENSMUSP00000044376 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | Parkin coregulated gene protein homolog; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity). | 0.734 |
Cfap20 | Ribc2 | ENSMUSP00000034249 | ENSMUSP00000023067 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | RIB43A-like with coiled-coils protein 2; Belongs to the RIB43A family. | 0.691 |
Cfap20 | Tbc1d32 | ENSMUSP00000034249 | ENSMUSP00000097328 | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | Protein broad-minded; Required for high-level Shh responses in the developing neural tube. Together with CDK20, controls the structure of the primary cilium by coordinating assembly of the ciliary membrane and axoneme, allowing GLI2 to be properly activated in response to Shh signaling. | 0.823 |
Cfap298 | Cfap20 | ENSMUSP00000023694 | ENSMUSP00000034249 | Cilia- and flagella-associated protein 298; Plays a role in motile cilium function, possibly by acting on outer dynein arm assembly. Seems to be important for initiation rather than maintenance of cilium motility. Required for correct positioning of cilia at the apical cell surface, suggesting an additional role in the planar cell polarity (PCP) pathway. May suppress canonical Wnt signaling activity. | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | 0.742 |
Cfap45 | Cfap20 | ENSMUSP00000083057 | ENSMUSP00000034249 | Cilia and flagella-associated protein 45. | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | 0.700 |
Cfap45 | Cfap52 | ENSMUSP00000083057 | ENSMUSP00000021287 | Cilia and flagella-associated protein 45. | Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. | 0.917 |
Cfap45 | Efhc1 | ENSMUSP00000083057 | ENSMUSP00000042343 | Cilia and flagella-associated protein 45. | EF-hand domain-containing protein 1; Microtubule-associated protein which regulates cell division and neuronal migration during cortical development. Necessary for mitotic spindle organization. Necessary for radial and tangential cell migration during brain development, possibly acting as a regulator of cell morphology and process formation during migration (By similarity). May enhance calcium influx through CACNA1E and stimulate programmed cell death. Overexpression of EFHC1 in hippocampal primary culture neurons induced apoptosis. | 0.842 |
Cfap45 | Efhc2 | ENSMUSP00000083057 | ENSMUSP00000026014 | Cilia and flagella-associated protein 45. | EF-hand domain-containing family member C2. | 0.728 |
Cfap45 | Pacrg | ENSMUSP00000083057 | ENSMUSP00000044376 | Cilia and flagella-associated protein 45. | Parkin coregulated gene protein homolog; Suppresses cell death induced by accumulation of unfolded Pael receptor (Pael-R, a substrate of Parkin). Facilitates the formation of inclusions consisting of Pael-R, molecular chaperones, protein degradation molecules and itself when proteasome is inhibited (By similarity). | 0.746 |
Cfap45 | Ribc2 | ENSMUSP00000083057 | ENSMUSP00000023067 | Cilia and flagella-associated protein 45. | RIB43A-like with coiled-coils protein 2; Belongs to the RIB43A family. | 0.771 |
Cfap52 | Cfap20 | ENSMUSP00000021287 | ENSMUSP00000034249 | Cilia- and flagella-associated protein 52; May play a role in cell growth and/or survival. Belongs to the CFAP52 family. | Cilia- and flagella-associated protein 20; Cilium- and flagellum-specific protein that plays a role in axonemal structure organization and motility. Involved in the regulation of the size and morphology of cilia. Required for axonemal microtubules polyglutamylation (By similarity). | 0.687 |