STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
Ces2aPyrethroid hydrolase Ces2a; Carboxylesterases that catalyzes the hydrolysis of pyrethroids pesticides. Hydrolyzes permethrin faster than cypermethrin. (558 aa)    
Predicted Functional Partners:
Ugt2b5
UDP-glucuronosyltransferase 2B17; UDPGT is of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds.
   
 
 0.921
Gusb
Beta-glucuronidase; Plays an important role in the degradation of dermatan and keratan sulfates.
    
 0.916
Cda
Cytidine deaminase; This enzyme scavenges exogenous and endogenous cytidine and 2'-deoxycytidine for UMP synthesis.
   
 
 0.916
Ugt2b36
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 
 0.902
Ugt2a3
UDP-glucuronosyltransferase 2A3; UDP-glucuronosyltransferases catalyze phase II biotransformation reactions in which lipophilic substrates are conjugated with glucuronic acid to increase water solubility and enhance excretion. They are of major importance in the conjugation and subsequent elimination of potentially toxic xenobiotics and endogenous compounds (By similarity); Belongs to the UDP-glycosyltransferase family.
   
 
 0.895
Otc
Ornithine carbamoyltransferase, mitochondrial.
   
    0.864
Ugt2b1
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 
 0.853
Cyp2c68
Cytochrome P450, family 2, subfamily c, polypeptide 68; Belongs to the cytochrome P450 family.
   
  
 0.847
Fabp2
Fatty acid-binding protein, intestinal; FABP are thought to play a role in the intracellular transport of long-chain fatty acids and their acyl-CoA esters. FABP2 is probably involved in triglyceride-rich lipoprotein synthesis. Binds saturated long-chain fatty acids with a high affinity, but binds with a lower affinity to unsaturated long-chain fatty acids. FABP2 may also help maintain energy homeostasis by functioning as a lipid sensor. Belongs to the calycin superfamily. Fatty-acid binding protein (FABP) family.
   
  
 0.838
Ugt2b35
UDP-glucuronosyltransferase; Belongs to the UDP-glycosyltransferase family.
   
 
 0.837
Your Current Organism:
Mus musculus
NCBI taxonomy Id: 10090
Other names: LK3 transgenic mice, M. musculus, Mus sp. 129SV, house mouse, mouse, nude mice, transgenic mice
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