node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdk5rap1 | Dus2 | ENSMUSP00000105353 | ENSMUSP00000034375 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | 0.675 |
Cdk5rap1 | Eprs | ENSMUSP00000105353 | ENSMUSP00000045841 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | Bifunctional glutamate/proline--tRNA ligase; Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (By similarity). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex [...] | 0.473 |
Cdk5rap1 | Trit1 | ENSMUSP00000105353 | ENSMUSP00000099709 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.873 |
Cdk5rap1 | Trmt5 | ENSMUSP00000105353 | ENSMUSP00000112121 | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | tRNA (guanine(37)-N1)-methyltransferase; Involved in mitochondrial tRNA methylation (By similarity). Specifically methylates the N1 position of guanosine-37 in various tRNAs. Methylation is not dependent on the nature of the nucleoside 5' of the target nucleoside. This is the first step in the biosynthesis of wybutosine (yW), a modified base adjacent to the anticodon of tRNAs and required for accurate decoding. | 0.645 |
Comtd1 | Dus2 | ENSMUSP00000119330 | ENSMUSP00000034375 | Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase. | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | 0.684 |
Comtd1 | Map6d1 | ENSMUSP00000119330 | ENSMUSP00000043332 | Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase. | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity. | 0.626 |
Ddx28 | Dus2 | ENSMUSP00000058950 | ENSMUSP00000034375 | Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (By similarity); Belongs to the DEAD box helicase family. | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | 0.768 |
Dtwd1 | Dtwd2 | ENSMUSP00000127662 | ENSMUSP00000128219 | DTW domain-containing protein 1. | DTW domain-containing protein 2. | 0.797 |
Dtwd1 | Dus2 | ENSMUSP00000127662 | ENSMUSP00000034375 | DTW domain-containing protein 1. | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | 0.653 |
Dtwd2 | Dtwd1 | ENSMUSP00000128219 | ENSMUSP00000127662 | DTW domain-containing protein 2. | DTW domain-containing protein 1. | 0.797 |
Dtwd2 | Dus2 | ENSMUSP00000128219 | ENSMUSP00000034375 | DTW domain-containing protein 2. | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | 0.681 |
Dus2 | Cdk5rap1 | ENSMUSP00000034375 | ENSMUSP00000105353 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | CDK5 regulatory subunit-associated protein 1; Probable regulator of CDK5 activity. May inhibit CDK5 function via its interaction with CDK5R1 (By similarity). | 0.675 |
Dus2 | Comtd1 | ENSMUSP00000034375 | ENSMUSP00000119330 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | Catechol O-methyltransferase domain-containing protein 1; Putative O-methyltransferase. | 0.684 |
Dus2 | Ddx28 | ENSMUSP00000034375 | ENSMUSP00000058950 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | Probable ATP-dependent RNA helicase DDX28; Plays an essential role in facilitating the proper assembly of the mitochondrial large ribosomal subunit and its helicase activity is essential for this function. May be involved in RNA processing or transport. Has RNA and Mg(2+)-dependent ATPase activity (By similarity); Belongs to the DEAD box helicase family. | 0.768 |
Dus2 | Dtwd1 | ENSMUSP00000034375 | ENSMUSP00000127662 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | DTW domain-containing protein 1. | 0.653 |
Dus2 | Dtwd2 | ENSMUSP00000034375 | ENSMUSP00000128219 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | DTW domain-containing protein 2. | 0.681 |
Dus2 | Eprs | ENSMUSP00000034375 | ENSMUSP00000045841 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | Bifunctional glutamate/proline--tRNA ligase; Multifunctional protein which is primarily part of the aminoacyl-tRNA synthetase multienzyme complex, also know as multisynthetase complex, that catalyzes the attachment of the cognate amino acid to the corresponding tRNA in a two-step reaction: the amino acid is first activated by ATP to form a covalent intermediate with AMP and is then transferred to the acceptor end of the cognate tRNA (By similarity). The phosphorylation of EPRS1, induced by interferon-gamma, dissociates the protein from the aminoacyl-tRNA synthetase multienzyme complex [...] | 0.789 |
Dus2 | Map6d1 | ENSMUSP00000034375 | ENSMUSP00000043332 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | MAP6 domain-containing protein 1; May have microtubule-stabilizing activity. | 0.658 |
Dus2 | Pqlc2 | ENSMUSP00000034375 | ENSMUSP00000059772 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | Lysosomal amino acid transporter 1 homolog; Amino acid transporter that specifically mediates the pH- dependent export of the cationic amino acids arginine, histidine and lysine from lysosomes. | 0.829 |
Dus2 | Trit1 | ENSMUSP00000034375 | ENSMUSP00000099709 | tRNA-dihydrouridine(20) synthase [NAD(P)+]-like; Dihydrouridine synthase. Catalyzes the NADPH-dependent synthesis of dihydrouridine, a modified base found in the D-loop of most tRNAs. Negatively regulates the activation of EIF2AK2/PKR. Belongs to the Dus family. Dus2 subfamily. | tRNA dimethylallyltransferase; Catalyzes the transfer of a dimethylallyl group onto the adenine at position 37 of both cytosolic and mitochondrial tRNAs, leading to the formation of N6-(dimethylallyl)adenosine (i(6)A). | 0.678 |