node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1300017J02Rik | Ambp | ENSMUSP00000035163 | ENSMUSP00000030041 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity); In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | 0.496 |
1300017J02Rik | Disp1 | ENSMUSP00000035163 | ENSMUSP00000003035 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion. Belongs to the dispatched family. | 0.530 |
1300017J02Rik | F2 | ENSMUSP00000035163 | ENSMUSP00000028681 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.575 |
1300017J02Rik | Ica1 | ENSMUSP00000035163 | ENSMUSP00000040062 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Islet cell autoantigen 1; May play a role in neurotransmitter secretion. | 0.473 |
1300017J02Rik | Mug1 | ENSMUSP00000035163 | ENSMUSP00000032228 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Murinoglobulin-1; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] | 0.632 |
1300017J02Rik | Plg | ENSMUSP00000035163 | ENSMUSP00000014578 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.503 |
1300017J02Rik | Srprb | ENSMUSP00000035163 | ENSMUSP00000035157 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Signal recognition particle receptor subunit beta; Component of the SRP (signal recognition particle) receptor. Ensures, in conjunction with the signal recognition particle, the correct targeting of the nascent secretory proteins to the endoplasmic reticulum membrane system. Has GTPase activity. May mediate the membrane association of SRPR. | 0.828 |
1300017J02Rik | Tfr2 | ENSMUSP00000035163 | ENSMUSP00000142720 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Transferrin receptor protein 2; Mediates cellular uptake of transferrin-bound iron in a non- iron dependent manner. May be involved in iron metabolism, hepatocyte function and erythrocyte differentiation; Belongs to the peptidase M28 family. M28B subfamily. | 0.584 |
1300017J02Rik | Tfrc | ENSMUSP00000035163 | ENSMUSP00000023486 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Transferrin receptor protein 1; Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). Upon stimulation, positively regulates T and B cell proliferation through iron uptake ; Belongs to t [...] | 0.977 |
1300017J02Rik | Trf | ENSMUSP00000035163 | ENSMUSP00000035158 | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. | 0.908 |
Ambp | 1300017J02Rik | ENSMUSP00000030041 | ENSMUSP00000035163 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity); In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | 0.496 |
Ambp | F2 | ENSMUSP00000030041 | ENSMUSP00000028681 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity); In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | 0.946 |
Ambp | Mug1 | ENSMUSP00000030041 | ENSMUSP00000032228 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity); In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Murinoglobulin-1; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] | 0.720 |
Ambp | Plg | ENSMUSP00000030041 | ENSMUSP00000014578 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity); In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.874 |
Ambp | Trf | ENSMUSP00000030041 | ENSMUSP00000035158 | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity); In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | Serotransferrin; Transferrins are iron binding transport proteins which can bind two Fe(3+) ions in association with the binding of an anion, usually bicarbonate. It is responsible for the transport of iron from sites of absorption and heme degradation to those of storage and utilization. Serum transferrin may also have a further role in stimulating cell proliferation. | 0.443 |
Disp1 | 1300017J02Rik | ENSMUSP00000003035 | ENSMUSP00000035163 | Protein dispatched homolog 1; Functions in hedgehog (Hh) signaling. Regulates the release and extracellular accumulation of cholesterol-modified hedgehog proteins and is hence required for effective production of the Hh signal. Synergizes with SCUBE2 to cause an increase in SHH secretion. Belongs to the dispatched family. | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | 0.530 |
F2 | 1300017J02Rik | ENSMUSP00000028681 | ENSMUSP00000035163 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Inhibitor of carbonic anhydrase; Inhibitor for carbonic anhydrase 2 (CA2). Does not bind iron ions. | 0.575 |
F2 | Ambp | ENSMUSP00000028681 | ENSMUSP00000030041 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Inter-alpha-trypsin inhibitor light chain; Inter-alpha-trypsin inhibitor inhibits trypsin, plasmin, and lysosomal granulocytic elastase. Inhibits calcium oxalate crystallization (By similarity); In the N-terminal section; belongs to the calycin superfamily. Lipocalin family. | 0.946 |
F2 | Mug1 | ENSMUSP00000028681 | ENSMUSP00000032228 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Murinoglobulin-1; A proteinase activates the inhibitor by specific proteolysis in the bait region, which, by an unknown mechanism leads to reaction at the cysteinyl-glutamyl internal thiol ester site and to a conformational change, whereby the proteinase is trapped and/or covalently bound to the inhibitor. While in the tetrameric proteinase inhibitors steric inhibition is sufficiently strong, monomeric forms need a covalent linkage between the activated glutamyl residue of the original thiol ester and a terminal amino group of a lysine or another nucleophilic group on the proteinase, f [...] | 0.652 |
F2 | Plg | ENSMUSP00000028681 | ENSMUSP00000014578 | Activation peptide fragment 1; Thrombin, which cleaves bonds after Arg and Lys, converts fibrinogen to fibrin and activates factors V, VII, VIII, XIII, and, in complex with thrombomodulin, protein C. Functions in blood homeostasis, inflammation and wound healing (By similarity). | Plasmin heavy chain A, short form; Plasmin dissolves the fibrin of blood clots and acts as a proteolytic factor in a variety of other processes including embryonic development, tissue remodeling, tumor invasion, and inflammation. In ovulation, weakens the walls of the Graafian follicle. It activates the urokinase-type plasminogen activator, collagenases and several complement zymogens, such as C1 and C5. Cleavage of fibronectin and laminin leads to cell detachment and apoptosis. Also cleaves fibrin, thrombospondin and von Willebrand factor. Its role in tissue remodeling and tumor invas [...] | 0.977 |