node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Acsl4 | Ammecr1 | ENSMUSP00000033634 | ENSMUSP00000036085 | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | AMME syndrome candidate gene 1 protein homolog. | 0.609 |
Ammecr1 | Acsl4 | ENSMUSP00000036085 | ENSMUSP00000033634 | AMME syndrome candidate gene 1 protein homolog. | Long-chain-fatty-acid--CoA ligase 4; Catalyzes the conversion of long-chain fatty acids to their active form acyl-CoA for both synthesis of cellular lipids, and degradation via beta-oxidation. Preferentially activates arachidonate and eicosapentaenoate as substrates. Preferentially activates 8,9-EET > 14,15-EET > 5,6-EET > 11,12-EET. Modulates glucose-stimulated insulin secretion by regulating the levels of unesterified EETs (By similarity). Modulates prostaglandin E2 secretion (By similarity). Belongs to the ATP-dependent AMP-binding enzyme family. | 0.609 |
Ammecr1 | Fam122b | ENSMUSP00000036085 | ENSMUSP00000069112 | AMME syndrome candidate gene 1 protein homolog. | Protein FAM122B. | 0.470 |
Ammecr1 | Kcne1l | ENSMUSP00000036085 | ENSMUSP00000127773 | AMME syndrome candidate gene 1 protein homolog. | Potassium voltage-gated channel subfamily E regulatory beta subunit 5; Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta- subunit of the repolarizing cardiac potassium ion channel KCNQ1. | 0.448 |
Ammecr1 | Memo1 | ENSMUSP00000036085 | ENSMUSP00000156607 | AMME syndrome candidate gene 1 protein homolog. | Protein MEMO1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). | 0.496 |
Ammecr1 | Pdzd11 | ENSMUSP00000036085 | ENSMUSP00000015812 | AMME syndrome candidate gene 1 protein homolog. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.546 |
Ammecr1 | Rtl9 | ENSMUSP00000036085 | ENSMUSP00000128287 | AMME syndrome candidate gene 1 protein homolog. | Retrotransposon Gag-like protein 9. | 0.645 |
Ammecr1 | Sh3bgrl | ENSMUSP00000036085 | ENSMUSP00000033598 | AMME syndrome candidate gene 1 protein homolog. | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.471 |
Ammecr1 | Tmem164 | ENSMUSP00000036085 | ENSMUSP00000108517 | AMME syndrome candidate gene 1 protein homolog. | Transmembrane protein 164. | 0.507 |
Ammecr1 | Trmt12 | ENSMUSP00000036085 | ENSMUSP00000047831 | AMME syndrome candidate gene 1 protein homolog. | tRNA wybutosine-synthesizing protein 2 homolog; S-adenosyl-L-methionine-dependent transferase that acts as a component of the wybutosine biosynthesis pathway. Wybutosine is a hyper modified guanosine with a tricyclic base found at the 3'-position adjacent to the anticodon of eukaryotic phenylalanine tRNA. Catalyzes the transfer of the alpha-amino-alpha-carboxypropyl (acp) group from S- adenosyl-L-methionine to the C-7 position of 4-demethylwyosine (imG-14) to produce wybutosine-86 (By similarity). | 0.530 |
Ammecr1 | Zbed4 | ENSMUSP00000036085 | ENSMUSP00000035437 | AMME syndrome candidate gene 1 protein homolog. | Zinc finger BED domain-containing protein 4. | 0.505 |
Fam122b | Ammecr1 | ENSMUSP00000069112 | ENSMUSP00000036085 | Protein FAM122B. | AMME syndrome candidate gene 1 protein homolog. | 0.470 |
Kcne1l | Ammecr1 | ENSMUSP00000127773 | ENSMUSP00000036085 | Potassium voltage-gated channel subfamily E regulatory beta subunit 5; Potassium channel ancillary subunit that is essential for generation of some native K(+) currents by virtue of formation of heteromeric ion channel complex with voltage-gated potassium (Kv) channel pore-forming alpha subunits. Functions as an inhibitory beta- subunit of the repolarizing cardiac potassium ion channel KCNQ1. | AMME syndrome candidate gene 1 protein homolog. | 0.448 |
Memo1 | Ammecr1 | ENSMUSP00000156607 | ENSMUSP00000036085 | Protein MEMO1; May control cell migration by relaying extracellular chemotactic signals to the microtubule cytoskeleton. Mediator of ERBB2 signaling. The MEMO1-RHOA-DIAPH1 signaling pathway plays an important role in ERBB2-dependent stabilization of microtubules at the cell cortex. It controls the localization of APC and CLASP2 to the cell membrane, via the regulation of GSK3B activity. In turn, membrane-bound APC allows the localization of the MACF1 to the cell membrane, which is required for microtubule capture and stabilization (By similarity). | AMME syndrome candidate gene 1 protein homolog. | 0.496 |
Pdzd11 | Ammecr1 | ENSMUSP00000015812 | ENSMUSP00000036085 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | AMME syndrome candidate gene 1 protein homolog. | 0.546 |
Pdzd11 | Sh3bgrl | ENSMUSP00000015812 | ENSMUSP00000033598 | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | 0.438 |
Rtl9 | Ammecr1 | ENSMUSP00000128287 | ENSMUSP00000036085 | Retrotransposon Gag-like protein 9. | AMME syndrome candidate gene 1 protein homolog. | 0.645 |
Rtl9 | Tmem164 | ENSMUSP00000128287 | ENSMUSP00000108517 | Retrotransposon Gag-like protein 9. | Transmembrane protein 164. | 0.521 |
Sh3bgrl | Ammecr1 | ENSMUSP00000033598 | ENSMUSP00000036085 | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | AMME syndrome candidate gene 1 protein homolog. | 0.471 |
Sh3bgrl | Pdzd11 | ENSMUSP00000033598 | ENSMUSP00000015812 | SH3 domain-binding glutamic acid-rich-like protein; Belongs to the SH3BGR family. | PDZ domain-containing protein 11; Mediates docking of ADAM10 to zonula adherens by interacting with PLEKHA7 which is required for PLEKHA7 to interact with the ADAM10- binding protein TSPAN33. | 0.438 |