node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgap39 | Cdc42 | ENSMUSP00000158945 | ENSMUSP00000054634 | Rho GTPase-activating protein 39. | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In its active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Req [...] | 0.545 |
Arhgap39 | Cnksr2 | ENSMUSP00000158945 | ENSMUSP00000026750 | Rho GTPase-activating protein 39. | Connector enhancer of kinase suppressor of ras 2; May function as an adapter protein or regulator of Ras signaling pathways; Belongs to the CNKSR family. | 0.571 |
Arhgap39 | Cpsf1 | ENSMUSP00000158945 | ENSMUSP00000071794 | Rho GTPase-activating protein 39. | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). | 0.597 |
Arhgap39 | Cyhr1 | ENSMUSP00000158945 | ENSMUSP00000134739 | Rho GTPase-activating protein 39. | Cysteine and histidine-rich protein 1; Belongs to the CYHR1 family. | 0.687 |
Arhgap39 | Fam83h | ENSMUSP00000158945 | ENSMUSP00000126453 | Rho GTPase-activating protein 39. | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family. | 0.595 |
Arhgap39 | Mroh1 | ENSMUSP00000158945 | ENSMUSP00000094115 | Rho GTPase-activating protein 39. | Maestro heat-like repeat family member 1. | 0.617 |
Arhgap39 | Ofd1 | ENSMUSP00000158945 | ENSMUSP00000041744 | Rho GTPase-activating protein 39. | Oral-facial-digital syndrome 1 protein homolog; Component of the centrioles controlling mother and daughter centrioles length. Recruits to the centriole IFT88 and centriole distal appendage-specific proteins including CEP164. Involved in the biogenesis of the cilium, a centriole-associated function. The cilium is a cell surface projection found in many vertebrate cells required to transduce signals important for development and tissue homeostasis. Plays an important role in development by regulating Wnt signaling and the specification of the left-right axis. Only OFD1 localized at the [...] | 0.656 |
Arhgap39 | Rhog | ENSMUSP00000158945 | ENSMUSP00000102536 | Rho GTPase-activating protein 39. | Rho-related GTP-binding protein RhoG; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity). | 0.534 |
Arhgap39 | Robo4 | ENSMUSP00000158945 | ENSMUSP00000150722 | Rho GTPase-activating protein 39. | Roundabout homolog 4; Receptor for Slit proteins, at least for SLIT2, and seems to be involved in angiogenesis and vascular patterning. May mediate the inhibition of primary endothelial cell migration by Slit proteins. Involved in the maintenance of endothelial barrier organization and function (By similarity); Belongs to the immunoglobulin superfamily. ROBO family. | 0.575 |
Arhgap39 | Tor1aip1 | ENSMUSP00000158945 | ENSMUSP00000095134 | Rho GTPase-activating protein 39. | Torsin-1A-interacting protein 1; Required for nuclear membrane integrity. Induces TOR1A and TOR1B ATPase activity and is required for their location on the nuclear membrane. Binds to A- and B-type lamins. Possible role in membrane attachment and assembly of the nuclear lamina. | 0.526 |
Cdc42 | Arhgap39 | ENSMUSP00000054634 | ENSMUSP00000158945 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In its active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Req [...] | Rho GTPase-activating protein 39. | 0.545 |
Cdc42 | Rhog | ENSMUSP00000054634 | ENSMUSP00000102536 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In its active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Regulates cell migration (By similarity). In neurons, plays a role in the extension and maintenance of the formation of filopodia, thin and actin-rich surface projections. Req [...] | Rho-related GTP-binding protein RhoG; Required for the formation of membrane ruffles during macropinocytosis. Plays a role in cell migration and is required for the formation of cup-like structures during trans-endothelial migration of leukocytes (By similarity). | 0.550 |
Cnksr2 | Arhgap39 | ENSMUSP00000026750 | ENSMUSP00000158945 | Connector enhancer of kinase suppressor of ras 2; May function as an adapter protein or regulator of Ras signaling pathways; Belongs to the CNKSR family. | Rho GTPase-activating protein 39. | 0.571 |
Cpsf1 | Arhgap39 | ENSMUSP00000071794 | ENSMUSP00000158945 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). | Rho GTPase-activating protein 39. | 0.597 |
Cpsf1 | Cyhr1 | ENSMUSP00000071794 | ENSMUSP00000134739 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). | Cysteine and histidine-rich protein 1; Belongs to the CYHR1 family. | 0.671 |
Cpsf1 | Fam83h | ENSMUSP00000071794 | ENSMUSP00000126453 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family. | 0.497 |
Cpsf1 | Mroh1 | ENSMUSP00000071794 | ENSMUSP00000094115 | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). | Maestro heat-like repeat family member 1. | 0.672 |
Cyhr1 | Arhgap39 | ENSMUSP00000134739 | ENSMUSP00000158945 | Cysteine and histidine-rich protein 1; Belongs to the CYHR1 family. | Rho GTPase-activating protein 39. | 0.687 |
Cyhr1 | Cpsf1 | ENSMUSP00000134739 | ENSMUSP00000071794 | Cysteine and histidine-rich protein 1; Belongs to the CYHR1 family. | Cleavage and polyadenylation specificity factor subunit 1; Component of the cleavage and polyadenylation specificity factor (CPSF) complex that plays a key role in pre-mRNA 3'-end formation, recognizing the AAUAAA signal sequence and interacting with poly(A) polymerase and other factors to bring about cleavage and poly(A) addition. This subunit is involved in the RNA recognition step of the polyadenylation reaction (By similarity). | 0.671 |
Cyhr1 | Fam83h | ENSMUSP00000134739 | ENSMUSP00000126453 | Cysteine and histidine-rich protein 1; Belongs to the CYHR1 family. | Protein FAM83H; May play a major role in the structural organization and calcification of developing enamel. May play a role in keratin cytoskeleton disassembly by recruiting CSNK1A1 to keratin filaments. Thereby, it may regulate epithelial cell migration. Belongs to the FAM83 family. | 0.578 |