node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ap1g2 | Arl5c | ENSMUSP00000043996 | ENSMUSP00000037214 | AP-1 complex subunit gamma-like 2; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV); Belongs to the adaptor complexes large subunit family. | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.405 |
Arfgap1 | Arl5c | ENSMUSP00000029092 | ENSMUSP00000037214 | ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, a [...] | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.406 |
Arfgap1 | Gbf1 | ENSMUSP00000029092 | ENSMUSP00000026254 | ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, a [...] | Golgi-specific brefeldin A-resistance factor 1. | 0.860 |
Arfgap1 | Itsn1 | ENSMUSP00000029092 | ENSMUSP00000109635 | ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, a [...] | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | 0.403 |
Arfgap1 | Itsn2 | ENSMUSP00000029092 | ENSMUSP00000052758 | ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, a [...] | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.400 |
Arl5c | Ap1g2 | ENSMUSP00000037214 | ENSMUSP00000043996 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | AP-1 complex subunit gamma-like 2; May function in protein sorting in late endosomes or multivesucular bodies (MVBs). Involved in MVB-assisted maturation of hepatitis B virus (HBV); Belongs to the adaptor complexes large subunit family. | 0.405 |
Arl5c | Arfgap1 | ENSMUSP00000037214 | ENSMUSP00000029092 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, a [...] | 0.406 |
Arl5c | Gbf1 | ENSMUSP00000037214 | ENSMUSP00000026254 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Golgi-specific brefeldin A-resistance factor 1. | 0.489 |
Arl5c | Gm11939 | ENSMUSP00000037214 | ENSMUSP00000100536 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Predicted gene 11939. | 0.707 |
Arl5c | Gtf3c5 | ENSMUSP00000037214 | ENSMUSP00000109521 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity); Belongs to the TFIIIC subunit 5 family. | 0.452 |
Arl5c | Itsn1 | ENSMUSP00000037214 | ENSMUSP00000109635 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Intersectin-1; Adapter protein that provides a link between the endocytic membrane traffic and the actin assembly machinery. Acts as guanine nucleotide exchange factor (GEF) for CDC42, and thereby stimulates actin nucleation mediated by WASL and the ARP2/3 complex (By similarity). Plays a role in the assembly and maturation of clathrin- coated vesicles (By similarity). Recruits FCHSD2 to clathrin-coated pits (By similarity). Involved in endocytosis of activated EGFR, and probably also other growth factor receptors. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin rece [...] | 0.593 |
Arl5c | Itsn2 | ENSMUSP00000037214 | ENSMUSP00000052758 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Intersectin-2; Adapter protein that may provide indirect link between the endocytic membrane traffic and the actin assembly machinery. May regulate the formation of clathrin-coated vesicles (CCPs). Seems to be involved in CCPs maturation including invagination or budding. Involved in endocytosis of integrin beta-1 (ITGB1) and transferrin receptor (TFR). Plays a role in dendrite formation by melanocytes. | 0.629 |
Arl5c | Krt40 | ENSMUSP00000037214 | ENSMUSP00000073869 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Keratin, type I cytoskeletal 40; May play a role in late hair differentiation. | 0.415 |
Arl5c | Vwa5b1 | ENSMUSP00000037214 | ENSMUSP00000030533 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | Von Willebrand factor A domain-containing protein 5B1. | 0.671 |
Arl5c | Wdr89 | ENSMUSP00000037214 | ENSMUSP00000050532 | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | WD repeat-containing protein 89. | 0.505 |
Gbf1 | Arfgap1 | ENSMUSP00000026254 | ENSMUSP00000029092 | Golgi-specific brefeldin A-resistance factor 1. | ADP-ribosylation factor GTPase-activating protein 1; GTPase-activating protein (GAP) for the ADP ribosylation factor 1 (ARF1). Involved in membrane trafficking and /or vesicle transport. Promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. Probably regulates ARF1-mediated transport via its interaction with the KDELR proteins and TMED2. Overexpression induces the redistribution of the entire Golgi complex to the endoplasmic reticulum, a [...] | 0.860 |
Gbf1 | Arl5c | ENSMUSP00000026254 | ENSMUSP00000037214 | Golgi-specific brefeldin A-resistance factor 1. | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.489 |
Gm11939 | Arl5c | ENSMUSP00000100536 | ENSMUSP00000037214 | Predicted gene 11939. | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.707 |
Gm11939 | Krt40 | ENSMUSP00000100536 | ENSMUSP00000073869 | Predicted gene 11939. | Keratin, type I cytoskeletal 40; May play a role in late hair differentiation. | 0.681 |
Gtf3c5 | Arl5c | ENSMUSP00000109521 | ENSMUSP00000037214 | General transcription factor 3C polypeptide 5; Involved in RNA polymerase III-mediated transcription. Integral, tightly associated component of the DNA-binding TFIIIC2 subcomplex that directly binds tRNA and virus-associated RNA promoters (By similarity); Belongs to the TFIIIC subunit 5 family. | ADP-ribosylation factor-like protein 5C; Binds and exchanges GTP and GDP. | 0.452 |