node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Fbrsl1 | Slc38a8 | ENSMUSP00000063879 | ENSMUSP00000038438 | Fibrosin-like 1. | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | 0.401 |
Frmd7 | Gpr143 | ENSMUSP00000057103 | ENSMUSP00000026383 | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. | 0.770 |
Frmd7 | Slc38a8 | ENSMUSP00000057103 | ENSMUSP00000038438 | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | 0.476 |
Gpr143 | Frmd7 | ENSMUSP00000026383 | ENSMUSP00000057103 | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. | 0.770 |
Gpr143 | Slc38a8 | ENSMUSP00000026383 | ENSMUSP00000038438 | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | 0.412 |
Noxred1 | Slc38a8 | ENSMUSP00000152486 | ENSMUSP00000038438 | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | 0.414 |
Slc25a35 | Slc38a8 | ENSMUSP00000099666 | ENSMUSP00000038438 | Solute carrier family 25 member 35. | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | 0.463 |
Slc25a35 | Svopl | ENSMUSP00000099666 | ENSMUSP00000093743 | Solute carrier family 25 member 35. | Putative transporter SVOPL; Belongs to the major facilitator superfamily. | 0.477 |
Slc38a8 | Fbrsl1 | ENSMUSP00000038438 | ENSMUSP00000063879 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | Fibrosin-like 1. | 0.401 |
Slc38a8 | Frmd7 | ENSMUSP00000038438 | ENSMUSP00000057103 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | FERM domain-containing protein 7; Plays a role in neurite development, may be through the activation of the GTPase RAC1. Plays a role in the control of eye movement and gaze stability. | 0.476 |
Slc38a8 | Gpr143 | ENSMUSP00000038438 | ENSMUSP00000026383 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | G-protein coupled receptor 143; Receptor for tyrosine, L-DOPA and dopamine. After binding to L-DOPA, stimulates Ca(2+) influx into the cytoplasm, increases secretion of the neurotrophic factor SERPINF1 and relocalizes beta arrestin at the plasma membrane; this ligand-dependent signaling occurs through a G(q)-mediated pathway in melanocytic cells. Its activity is mediated by G proteins which activate the phosphoinositide signaling pathway. Plays also a role as an intracellular G protein-coupled receptor involved in melanosome biogenesis, organization and transport. | 0.412 |
Slc38a8 | Noxred1 | ENSMUSP00000038438 | ENSMUSP00000152486 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | NADP-dependent oxidoreductase domain-containing protein 1; Probable oxidoreductase. | 0.414 |
Slc38a8 | Slc25a35 | ENSMUSP00000038438 | ENSMUSP00000099666 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | Solute carrier family 25 member 35. | 0.463 |
Slc38a8 | Slc38a9 | ENSMUSP00000038438 | ENSMUSP00000052172 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | 0.483 |
Slc38a8 | Slc7a8 | ENSMUSP00000038438 | ENSMUSP00000022787 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administe [...] | 0.458 |
Slc38a8 | Svopl | ENSMUSP00000038438 | ENSMUSP00000093743 | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | Putative transporter SVOPL; Belongs to the major facilitator superfamily. | 0.400 |
Slc38a9 | Slc38a8 | ENSMUSP00000052172 | ENSMUSP00000038438 | Sodium-coupled neutral amino acid transporter 9; Lysosomal amino acid transporter involved in the activation of mTORC1 in response to amino acid levels. Probably acts as an amino acid sensor of the Rag GTPases and Ragulator complexes, 2 complexes involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Following activation by amino acids, the Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. SLC38A9 mediates transport of a [...] | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | 0.483 |
Slc7a8 | Slc38a8 | ENSMUSP00000022787 | ENSMUSP00000038438 | Large neutral amino acids transporter small subunit 2; Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administe [...] | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | 0.458 |
Svopl | Slc25a35 | ENSMUSP00000093743 | ENSMUSP00000099666 | Putative transporter SVOPL; Belongs to the major facilitator superfamily. | Solute carrier family 25 member 35. | 0.477 |
Svopl | Slc38a8 | ENSMUSP00000093743 | ENSMUSP00000038438 | Putative transporter SVOPL; Belongs to the major facilitator superfamily. | Putative sodium-coupled neutral amino acid transporter 8; Putative sodium-dependent amino acid/proton antiporter. | 0.400 |