node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adamts7 | Hhipl1 | ENSMUSP00000108682 | ENSMUSP00000021685 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | HHIP-like protein 1; Belongs to the HHIP family. | 0.444 |
Adamts7 | Jcad | ENSMUSP00000108682 | ENSMUSP00000038613 | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | Junctional protein associated with coronary artery disease. | 0.489 |
Adnp2 | Jcad | ENSMUSP00000068560 | ENSMUSP00000038613 | Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | Junctional protein associated with coronary artery disease. | 0.506 |
Exosc9 | Jcad | ENSMUSP00000029269 | ENSMUSP00000038613 | Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | Junctional protein associated with coronary artery disease. | 0.412 |
Hhipl1 | Adamts7 | ENSMUSP00000021685 | ENSMUSP00000108682 | HHIP-like protein 1; Belongs to the HHIP family. | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | 0.444 |
Hhipl1 | Jcad | ENSMUSP00000021685 | ENSMUSP00000038613 | HHIP-like protein 1; Belongs to the HHIP family. | Junctional protein associated with coronary artery disease. | 0.506 |
Jcad | Adamts7 | ENSMUSP00000038613 | ENSMUSP00000108682 | Junctional protein associated with coronary artery disease. | A disintegrin and metalloproteinase with thrombospondin motifs 7; Metalloprotease that may play a role in the degradation of COMP. | 0.489 |
Jcad | Adnp2 | ENSMUSP00000038613 | ENSMUSP00000068560 | Junctional protein associated with coronary artery disease. | Activity-dependent neuroprotector homeobox protein 2; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.506 |
Jcad | Exosc9 | ENSMUSP00000038613 | ENSMUSP00000029269 | Junctional protein associated with coronary artery disease. | Exosome complex component RRP45; Non-catalytic component of the RNA exosome complex which has 3'->5' exoribonuclease activity and participates in a multitude of cellular RNA processing and degradation events. In the nucleus, the RNA exosome complex is involved in proper maturation of stable RNA species such as rRNA, snRNA and snoRNA, in the elimination of RNA processing by-products and non-coding 'pervasive' transcripts, such as antisense RNA species and promoter-upstream transcripts (PROMPTs), and of mRNAs with processing defects, thereby limiting or excluding their export to the cyto [...] | 0.412 |
Jcad | Hhipl1 | ENSMUSP00000038613 | ENSMUSP00000021685 | Junctional protein associated with coronary artery disease. | HHIP-like protein 1; Belongs to the HHIP family. | 0.506 |
Jcad | Lats2 | ENSMUSP00000038613 | ENSMUSP00000022531 | Junctional protein associated with coronary artery disease. | Serine/threonine-protein kinase LATS2; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus [...] | 0.630 |
Jcad | Magi3 | ENSMUSP00000038613 | ENSMUSP00000112934 | Junctional protein associated with coronary artery disease. | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the [...] | 0.443 |
Jcad | Nckap5l | ENSMUSP00000038613 | ENSMUSP00000023747 | Junctional protein associated with coronary artery disease. | Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L- mediated microtubule bundle formation. | 0.428 |
Jcad | Ttc7 | ENSMUSP00000038613 | ENSMUSP00000040771 | Junctional protein associated with coronary artery disease. | Tetratricopeptide repeat protein 7A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity). | 0.475 |
Lats2 | Jcad | ENSMUSP00000022531 | ENSMUSP00000038613 | Serine/threonine-protein kinase LATS2; Negative regulator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ size control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1, in complex with its regulatory protein SAV1, phosphorylates and activates LATS1/2 in complex with its regulatory protein MOB1, which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS2 inhibits its translocation into the nucleus [...] | Junctional protein associated with coronary artery disease. | 0.630 |
Magi3 | Jcad | ENSMUSP00000112934 | ENSMUSP00000038613 | Membrane-associated guanylate kinase, WW and PDZ domain-containing protein 3; Acts as a scaffolding protein at cell-cell junctions, thereby regulating various cellular and signaling processes. Cooperates with PTEN to modulate the kinase activity of AKT1. Its interaction with PTPRB and tyrosine phosphorylated proteins suggests that it may link receptor tyrosine phosphatase with its substrates at the plasma membrane. In polarized epithelial cells, involved in efficient trafficking of TGFA to the cell surface. Regulates the ability of LPAR2 to activate ERK and RhoA pathways. Regulates the [...] | Junctional protein associated with coronary artery disease. | 0.443 |
Nckap5l | Jcad | ENSMUSP00000023747 | ENSMUSP00000038613 | Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L- mediated microtubule bundle formation. | Junctional protein associated with coronary artery disease. | 0.428 |
Ttc7 | Jcad | ENSMUSP00000040771 | ENSMUSP00000038613 | Tetratricopeptide repeat protein 7A; Component of a complex required to localize phosphatidylinositol 4-kinase (PI4K) to the plasma membrane. The complex acts as a regulator of phosphatidylinositol 4-phosphate (PtdIns(4)P) synthesis (By similarity). In the complex, plays a central role in bridging PI4KA to EFR3B and FAM126A, via direct interactions (By similarity). | Junctional protein associated with coronary artery disease. | 0.475 |