node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cmpk2 | Ddx60 | ENSMUSP00000020969 | ENSMUSP00000070741 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | 0.759 |
Cmpk2 | Ifi44 | ENSMUSP00000020969 | ENSMUSP00000029671 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 0.803 |
Cmpk2 | Ifit1 | ENSMUSP00000020969 | ENSMUSP00000099888 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | 0.839 |
Cmpk2 | Oas2 | ENSMUSP00000020969 | ENSMUSP00000080209 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivi [...] | 0.756 |
Cmpk2 | Oasl1 | ENSMUSP00000020969 | ENSMUSP00000107771 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | 0.812 |
Cmpk2 | Parp14 | ENSMUSP00000020969 | ENSMUSP00000037657 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | Protein mono-ADP-ribosyltransferase PARP14; ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggeste [...] | 0.682 |
Cmpk2 | Rtp4 | ENSMUSP00000020969 | ENSMUSP00000147521 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | Receptor-transporting protein 4; Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (By similarity). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1. Belongs to the TMEM7 family. | 0.767 |
Cmpk2 | Slfn8 | ENSMUSP00000020969 | ENSMUSP00000040060 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | Schlafen family member 8; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. May be involved in immune system via regulation of inflammation. | 0.608 |
Cmpk2 | Trim30d | ENSMUSP00000020969 | ENSMUSP00000033211 | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | Tripartite motif-containing 30D. | 0.479 |
Ddx60 | Cmpk2 | ENSMUSP00000070741 | ENSMUSP00000020969 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | UMP-CMP kinase 2, mitochondrial; May participate in dUTP and dCTP synthesis in mitochondria. Is able to phosphorylate dUMP, dCMP, CMP, UMP and monophosphates of the pyrimidine nucleoside analogs ddC, dFdC, araC, BVDU and FdUrd with ATP as phosphate donor. Also displays broad nucleoside diphosphate kinase activity (By similarity). | 0.759 |
Ddx60 | Ifi44 | ENSMUSP00000070741 | ENSMUSP00000029671 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 0.847 |
Ddx60 | Ifit1 | ENSMUSP00000070741 | ENSMUSP00000099888 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | Interferon-induced protein with tetratricopeptide repeats 1; Interferon-induced antiviral RNA-binding protein that specifically binds single-stranded RNA bearing a 5'-triphosphate group (PPP-RNA), thereby acting as a sensor of viral single-stranded RNAs and inhibiting expression of viral messenger RNAs. Single-stranded PPP- RNAs, which lack 2'-O-methylation of the 5' cap and bear a 5'- triphosphate group instead, are specific from viruses, providing a molecular signature to distinguish between self and non-self mRNAs by the host during viral infection. Directly binds PPP-RNA in a non- [...] | 0.898 |
Ddx60 | Oas2 | ENSMUSP00000070741 | ENSMUSP00000080209 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | 2'-5'-oligoadenylate synthase 2; Interferon-induced, dsRNA-activated antiviral enzyme which plays a critical role in cellular innate antiviral response. Activated by detection of double stranded RNA (dsRNA): polymerizes higher oligomers of 2'-5'- oligoadenylates (2-5A) from ATP which then bind to the inactive monomeric form of ribonuclease L (RNASEL) leading to its dimerization and subsequent activation. Activation of RNASEL leads to degradation of cellular as well as viral RNA, resulting in the inhibition of protein synthesis, thus terminating viral replication. Can mediate the antivi [...] | 0.777 |
Ddx60 | Oasl1 | ENSMUSP00000070741 | ENSMUSP00000107771 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | 0.771 |
Ddx60 | Parp14 | ENSMUSP00000070741 | ENSMUSP00000037657 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | Protein mono-ADP-ribosyltransferase PARP14; ADP-ribosyltransferase that mediates mono-ADP-ribosylation of glutamate residues on target proteins. In contrast to PARP1 and PARP2, it is not able to mediate poly-ADP-ribosylation (By similarity). Catalyzes mono-ADP-ribosylating STAT1 at 'Glu-657' and 'Glu-705' and thus decreasing STAT1 phosphorylation, negatively regulates pro-inflammatory cytokines production in macrophages in response to IFNG stimulation. However, the role of ADP-ribosylation in the prevention of STAT1 phosphorylation has been called into question and it has been suggeste [...] | 0.633 |
Ddx60 | Rtp4 | ENSMUSP00000070741 | ENSMUSP00000147521 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | Receptor-transporting protein 4; Probable chaperone protein which facilitates trafficking and functional cell surface expression of some G-protein coupled receptors (GPCRs). Promotes functional expression of the bitter taste receptor TAS2R16 (By similarity). Also promotes functional expression of the opioid receptor heterodimer OPRD1-OPRM1. Belongs to the TMEM7 family. | 0.767 |
Ddx60 | Slfn8 | ENSMUSP00000070741 | ENSMUSP00000040060 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | Schlafen family member 8; Endoribonuclease that cleaves tRNAs and rRNAs. Cleaves tRNAs 11 nucleotides from the 3'-terminus at the acceptor stem. May be involved in immune system via regulation of inflammation. | 0.552 |
Ddx60 | Trim30d | ENSMUSP00000070741 | ENSMUSP00000033211 | DEAD (Asp-Glu-Ala-Asp) box polypeptide 60. | Tripartite motif-containing 30D. | 0.555 |
Ifi209 | Ifi44 | ENSMUSP00000061900 | ENSMUSP00000029671 | Pyrin and HIN domain-containing protein 1. | Interferon-induced protein 44; This protein aggregates to form microtubular structures. Belongs to the IFI44 family. | 0.416 |
Ifi209 | Oasl1 | ENSMUSP00000061900 | ENSMUSP00000107771 | Pyrin and HIN domain-containing protein 1. | 2'-5'-oligoadenylate synthase-like protein 1; Does not have 2'-5'-OAS activity, but can bind double- stranded RNA. Displays antiviral activity via an alternative antiviral pathway independent of RNase L; Belongs to the 2-5A synthase family. | 0.404 |