node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arl6ip6 | Rnf122 | ENSMUSP00000028336 | ENSMUSP00000040478 | ADP-ribosylation factor-like protein 6-interacting protein 6. | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.523 |
Dusp26 | Rnf122 | ENSMUSP00000046794 | ENSMUSP00000040478 | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.533 |
Fam234a | L3hypdh | ENSMUSP00000110639 | ENSMUSP00000019862 | Protein FAM234A. | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | 0.563 |
Fam234a | Rnf122 | ENSMUSP00000110639 | ENSMUSP00000040478 | Protein FAM234A. | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.537 |
L3hypdh | Fam234a | ENSMUSP00000019862 | ENSMUSP00000110639 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | Protein FAM234A. | 0.563 |
L3hypdh | Rnf122 | ENSMUSP00000019862 | ENSMUSP00000040478 | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.545 |
Mex3c | Rnf122 | ENSMUSP00000089463 | ENSMUSP00000040478 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | 0.618 |
Mex3c | Rnf125 | ENSMUSP00000089463 | ENSMUSP00000058251 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation. | 0.604 |
Mex3c | Rnf135 | ENSMUSP00000089463 | ENSMUSP00000017839 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | E3 ubiquitin-protein ligase RNF135; E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates th [...] | 0.701 |
Mex3c | Trim25 | ENSMUSP00000089463 | ENSMUSP00000103528 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | E3 ubiquitin/ISG15 ligase TRIM25; Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates e [...] | 0.742 |
Mex3c | Trim40 | ENSMUSP00000089463 | ENSMUSP00000084400 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | Tripartite motif-containing protein 40; May function as an E3 ubiquitin-protein ligase of the NEDD8 conjugation pathway. Promotes neddylation of IKBKG/NEMO, stabilizing NFKBIA, and inhibiting of NF-kappaB nuclear translocation and activity (By similarity); Belongs to the TRIM/RBCC family. | 0.447 |
Mex3c | Usp3 | ENSMUSP00000089463 | ENSMUSP00000122199 | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | Ubiquitin carboxyl-terminal hydrolase 3; Hydrolase that deubiquitinates monoubiquitinated target proteins such as histone H2A and H2B. Required for proper progression through S phase and subsequent mitotic entry. May regulate the DNA damage response (DDR) checkpoint through deubiquitination of H2A at DNA damage sites. Associates with the chromatin (By similarity). | 0.496 |
Rnf122 | Arl6ip6 | ENSMUSP00000040478 | ENSMUSP00000028336 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | ADP-ribosylation factor-like protein 6-interacting protein 6. | 0.523 |
Rnf122 | Dusp26 | ENSMUSP00000040478 | ENSMUSP00000046794 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | Dual specificity protein phosphatase 26; Inactivates MAPK1 and MAPK3 which leads to dephosphorylation of heat shock factor protein 4 and a reduction in its DNA-binding activity. | 0.533 |
Rnf122 | Fam234a | ENSMUSP00000040478 | ENSMUSP00000110639 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | Protein FAM234A. | 0.537 |
Rnf122 | L3hypdh | ENSMUSP00000040478 | ENSMUSP00000019862 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | Trans-L-3-hydroxyproline dehydratase; Catalyzes the dehydration of trans-3-hydroxy-L-proline to delta-1-pyrroline-2-carboxylate (Pyr2C). | 0.545 |
Rnf122 | Mex3c | ENSMUSP00000040478 | ENSMUSP00000089463 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | RNA-binding E3 ubiquitin-protein ligase MEX3C; RNA-binding protein. May be involved in post-transcriptional regulatory mechanisms, modulating levels of some mRNAs by promoting their degradation in a way involving ubiquitin ligase activity. May act as suppressor of replication stress and chromosome missegregation. | 0.618 |
Rnf122 | Rnf125 | ENSMUSP00000040478 | ENSMUSP00000058251 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | E3 ubiquitin-protein ligase RNF125; E3 ubiquitin-protein ligase that mediates ubiquitination and subsequent proteasomal degradation of target proteins, such as DDX58/RIG-I, MAVS/IPS1, IFIH1/MDA5, JAK1 and p53/TP53. Acts as a negative regulator of type I interferon production by mediating ubiquitination of DDX58/RIG-I at 'Lys-181', leading to DDX58/RIG-I degradation. Mediates ubiquitination and subsequent degradation of p53/TP53. Mediates ubiquitination and subsequent degradation of JAK1. Acts as a positive regulator of T-cell activation. | 0.712 |
Rnf122 | Rnf135 | ENSMUSP00000040478 | ENSMUSP00000017839 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | E3 ubiquitin-protein ligase RNF135; E2-dependent E3 ubiquitin-protein ligase that functions as a RIG-I/DDX58 coreceptor in the sensing of viral RNAs in cell cytoplasm and the activation of the antiviral innate immune response. Together with the UBE2D3, UBE2N and UB2V1 E2 ligases, catalyzes the 'Lys-63'-linked polyubiquitination of RIG-I/DDX58 oligomerized on viral RNAs, an essential step in the activation of the RIG-I signaling pathway. Through a ubiquitin-independent parallel mechanism, which consists in bridging RIG-I/DDX58 filaments forming on longer viral RNAs, further activates th [...] | 0.552 |
Rnf122 | Trim25 | ENSMUSP00000040478 | ENSMUSP00000103528 | RING finger protein 122; May induce necrosis and apoptosis. May play a role in cell viability (By similarity). | E3 ubiquitin/ISG15 ligase TRIM25; Functions as a ubiquitin E3 ligase and as an ISG15 E3 ligase. Involved in innate immune defense against viruses by mediating ubiquitination of DDX58 and IFIH1. Mediates 'Lys-63'-linked polyubiquitination of the DDX58 N-terminal CARD-like region and may play a role in signal transduction that leads to the production of interferons in response to viral infection. Mediates 'Lys-63'-linked polyubiquitination of IFIH1. Promotes ISGylation of 14-3-3 sigma (SFN), an adapter protein implicated in the regulation of a large spectrum signaling pathway. Mediates e [...] | 0.551 |