node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgef10l | Dpysl4 | ENSMUSP00000101425 | ENSMUSP00000026551 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | 0.615 |
Arhgef10l | Dyrk3 | ENSMUSP00000101425 | ENSMUSP00000016670 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | Dual specificity tyrosine-phosphorylation-regulated kinase 3; Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (By similarity). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2- to-M transition, after the nuclear-envelope breakdown: acts by [...] | 0.604 |
Arhgef10l | Esrp2 | ENSMUSP00000101425 | ENSMUSP00000111639 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). | 0.573 |
Arhgef10l | Khk | ENSMUSP00000101425 | ENSMUSP00000031053 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. | 0.567 |
Arhgef10l | Lsm14b | ENSMUSP00000101425 | ENSMUSP00000055036 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | Protein LSM14 homolog B; May play a role in control of mRNA translation. Belongs to the LSM14 family. | 0.670 |
Arhgef10l | Nfatc3 | ENSMUSP00000101425 | ENSMUSP00000104931 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | Nuclear factor of activated T-cells, cytoplasmic 3; Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Along with NFATC4, involved in embryonic heart development. | 0.509 |
Arhgef10l | Resf1 | ENSMUSP00000101425 | ENSMUSP00000041180 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | Retroelement silencing factor 1; Plays a role in the regulation of imprinted gene expression, regulates repressive epigenetic modifications associated with SETDB1. Required for the recruitment or accumulation of SETDB1 to the endogenous retroviruses (ERVs) and maintenance of repressive chromatin configuration, contributing to a subset of the SETDB1-dependent ERV silencing in embryonic stem cells. | 0.584 |
Arhgef10l | Rhoa | ENSMUSP00000101425 | ENSMUSP00000007959 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (By similarity). [...] | 0.520 |
Arhgef10l | Rps24 | ENSMUSP00000101425 | ENSMUSP00000152944 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | 40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. | 0.576 |
Arhgef10l | Uso1 | ENSMUSP00000101425 | ENSMUSP00000031355 | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | General vesicular transport factor p115; General vesicular transport factor required for intercisternal transport in the Golgi stack; it is required for transcytotic fusion and/or subsequent binding of the vesicles to the target membrane. May well act as a vesicular anchor by interacting with the target membrane and holding the vesicular and target membranes in proximity; Belongs to the VDP/USO1/EDE1 family. | 0.541 |
Dpysl4 | Arhgef10l | ENSMUSP00000026551 | ENSMUSP00000101425 | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | 0.615 |
Dpysl4 | Dyrk3 | ENSMUSP00000026551 | ENSMUSP00000016670 | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | Dual specificity tyrosine-phosphorylation-regulated kinase 3; Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (By similarity). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2- to-M transition, after the nuclear-envelope breakdown: acts by [...] | 0.596 |
Dyrk3 | Arhgef10l | ENSMUSP00000016670 | ENSMUSP00000101425 | Dual specificity tyrosine-phosphorylation-regulated kinase 3; Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (By similarity). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2- to-M transition, after the nuclear-envelope breakdown: acts by [...] | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | 0.604 |
Dyrk3 | Dpysl4 | ENSMUSP00000016670 | ENSMUSP00000026551 | Dual specificity tyrosine-phosphorylation-regulated kinase 3; Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (By similarity). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2- to-M transition, after the nuclear-envelope breakdown: acts by [...] | Dihydropyrimidinase-related protein 4; Necessary for signaling by class 3 semaphorins and subsequent remodeling of the cytoskeleton. Plays a role in axon guidance, neuronal growth cone collapse and cell migration (By similarity); Belongs to the metallo-dependent hydrolases superfamily. Hydantoinase/dihydropyrimidinase family. | 0.596 |
Dyrk3 | Nfatc3 | ENSMUSP00000016670 | ENSMUSP00000104931 | Dual specificity tyrosine-phosphorylation-regulated kinase 3; Dual-specificity protein kinase that promotes disassembly of several types of membraneless organelles during mitosis, such as stress granules, nuclear speckles and pericentriolar material (By similarity). Dual-specificity tyrosine-regulated kinases (DYRKs) autophosphorylate a critical tyrosine residue in their activation loop and phosphorylate their substrate on serine and threonine residues. Acts as a central dissolvase of membraneless organelles during the G2- to-M transition, after the nuclear-envelope breakdown: acts by [...] | Nuclear factor of activated T-cells, cytoplasmic 3; Acts as a regulator of transcriptional activation. Plays a role in the inducible expression of cytokine genes in T-cells, especially in the induction of the IL-2 (By similarity). Along with NFATC4, involved in embryonic heart development. | 0.412 |
Esrp2 | Arhgef10l | ENSMUSP00000111639 | ENSMUSP00000101425 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | 0.573 |
Esrp2 | Lsm14b | ENSMUSP00000111639 | ENSMUSP00000055036 | Epithelial splicing regulatory protein 2; mRNA splicing factor that regulates the formation of epithelial cell-specific isoforms. Specifically regulates the expression of FGFR2-IIIb, an epithelial cell-specific isoform of FGFR2. Also regulates the splicing of CD44, CTNND1, ENAH, 3 transcripts that undergo changes in splicing during the epithelial-to-mesenchymal transition (EMT). Acts by directly binding specific sequences in mRNAs. Binds the GU-rich sequence motifs in the ISE/ISS-3, a cis-element regulatory region present in the mRNA of FGFR2 (By similarity). | Protein LSM14 homolog B; May play a role in control of mRNA translation. Belongs to the LSM14 family. | 0.546 |
Khk | Arhgef10l | ENSMUSP00000031053 | ENSMUSP00000101425 | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | 0.567 |
Khk | Rps24 | ENSMUSP00000031053 | ENSMUSP00000152944 | Ketohexokinase; Catalyzes the phosphorylation of the ketose sugar fructose to fructose-1-phosphate. | 40S ribosomal protein S24; Required for processing of pre-rRNA and maturation of 40S ribosomal subunits. | 0.527 |
Lsm14b | Arhgef10l | ENSMUSP00000055036 | ENSMUSP00000101425 | Protein LSM14 homolog B; May play a role in control of mRNA translation. Belongs to the LSM14 family. | Rho guanine nucleotide exchange factor 10-like protein; Acts as guanine nucleotide exchange factor (GEF) for RHOA, RHOB and RHOC. | 0.670 |