node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cux2 | Tcfl5 | ENSMUSP00000107381 | ENSMUSP00000040611 | Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. Belongs to the CUT homeobox family. | Transcription factor-like 5 (basic helix-loop-helix). | 0.411 |
Cylc1 | Hsf2bp | ENSMUSP00000098840 | ENSMUSP00000157466 | Cylicin, basic protein of sperm head cytoskeleton 1. | Heat shock factor 2-binding protein; Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis (By similarity). | 0.528 |
Cylc1 | Tcfl5 | ENSMUSP00000098840 | ENSMUSP00000040611 | Cylicin, basic protein of sperm head cytoskeleton 1. | Transcription factor-like 5 (basic helix-loop-helix). | 0.449 |
Figla | Tcfl5 | ENSMUSP00000032070 | ENSMUSP00000040611 | Factor in the germline alpha; Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the [...] | Transcription factor-like 5 (basic helix-loop-helix). | 0.459 |
Hsf2bp | Cylc1 | ENSMUSP00000157466 | ENSMUSP00000098840 | Heat shock factor 2-binding protein; Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis (By similarity). | Cylicin, basic protein of sperm head cytoskeleton 1. | 0.528 |
Hsf2bp | Tcfl5 | ENSMUSP00000157466 | ENSMUSP00000040611 | Heat shock factor 2-binding protein; Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis (By similarity). | Transcription factor-like 5 (basic helix-loop-helix). | 0.452 |
Nrf1 | Tcfl5 | ENSMUSP00000110860 | ENSMUSP00000040611 | Nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity). | Transcription factor-like 5 (basic helix-loop-helix). | 0.408 |
Osbpl2 | Tcfl5 | ENSMUSP00000046538 | ENSMUSP00000040611 | Oxysterol-binding protein-related protein 2; Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5- bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro); Belongs to the [...] | Transcription factor-like 5 (basic helix-loop-helix). | 0.501 |
R3hdm4 | Tcfl5 | ENSMUSP00000044570 | ENSMUSP00000040611 | R3H domain-containing protein 4. | Transcription factor-like 5 (basic helix-loop-helix). | 0.410 |
Rbm28 | Tcfl5 | ENSMUSP00000007993 | ENSMUSP00000040611 | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes. | Transcription factor-like 5 (basic helix-loop-helix). | 0.517 |
Spag16 | Tcfl5 | ENSMUSP00000069821 | ENSMUSP00000040611 | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia. | Transcription factor-like 5 (basic helix-loop-helix). | 0.461 |
Tcfl5 | Cux2 | ENSMUSP00000040611 | ENSMUSP00000107381 | Transcription factor-like 5 (basic helix-loop-helix). | Homeobox protein cut-like 2; Transcription factor involved in the control of neuronal proliferation and differentiation in the brain. Regulates dendrite development and branching, dendritic spine formation, and synaptogenesis in cortical layers II-III. Binds to DNA in a sequence-specific manner. Belongs to the CUT homeobox family. | 0.411 |
Tcfl5 | Cylc1 | ENSMUSP00000040611 | ENSMUSP00000098840 | Transcription factor-like 5 (basic helix-loop-helix). | Cylicin, basic protein of sperm head cytoskeleton 1. | 0.449 |
Tcfl5 | Figla | ENSMUSP00000040611 | ENSMUSP00000032070 | Transcription factor-like 5 (basic helix-loop-helix). | Factor in the germline alpha; Germ-line specific transcription factor implicated in postnatal oocyte-specific gene expression. Plays a key regulatory role in the expression of multiple oocyte-specific genes, including those that initiate folliculogenesis and those that encode the zona pellucida (ZP1, ZP2 and ZP3) required for fertilization and early embryonic survival. Essential for oocytes to survive and form primordial follicles. The persistence of FIGLA in adult females suggests that it may regulate additional pathways that are essential for normal ovarian development. Binds to the [...] | 0.459 |
Tcfl5 | Hsf2bp | ENSMUSP00000040611 | ENSMUSP00000157466 | Transcription factor-like 5 (basic helix-loop-helix). | Heat shock factor 2-binding protein; Inhibits BNC1 transcriptional activity during spermatogenesis, probably by sequestering it in the cytoplasm. May be involved in modulating HSF2 activation in testis (By similarity). | 0.452 |
Tcfl5 | Nrf1 | ENSMUSP00000040611 | ENSMUSP00000110860 | Transcription factor-like 5 (basic helix-loop-helix). | Nuclear respiratory factor 1; Transcription factor that activates the expression of the EIF2S1 (EIF2-alpha) gene. Links the transcriptional modulation of key metabolic genes to cellular growth and development. Implicated in the control of nuclear genes required for respiration, heme biosynthesis, and mitochondrial DNA transcription and replication (By similarity). | 0.408 |
Tcfl5 | Osbpl2 | ENSMUSP00000040611 | ENSMUSP00000046538 | Transcription factor-like 5 (basic helix-loop-helix). | Oxysterol-binding protein-related protein 2; Intracellular transport protein that binds sterols and phospholipids and mediates lipid transport between intracellular compartments. Increases plasma membrane cholesterol levels and decreases phosphatidylinositol-4,5-bisphosphate levels in the cell membrane. Binds phosphoinositides, such as phosphatidylinositol-4,5- bisphosphate. Exhibits strong binding to phosphatidic acid and weak binding to phosphatidylinositol 3-phosphate. Binds cholesterol, dehydroergosterol, 22(R)-hydroxycholesterol and 25-hydroxycholesterol (in vitro); Belongs to the [...] | 0.501 |
Tcfl5 | R3hdm4 | ENSMUSP00000040611 | ENSMUSP00000044570 | Transcription factor-like 5 (basic helix-loop-helix). | R3H domain-containing protein 4. | 0.410 |
Tcfl5 | Rbm28 | ENSMUSP00000040611 | ENSMUSP00000007993 | Transcription factor-like 5 (basic helix-loop-helix). | RNA-binding protein 28; Nucleolar component of the spliceosomal ribonucleoprotein complexes. | 0.517 |
Tcfl5 | Spag16 | ENSMUSP00000040611 | ENSMUSP00000069821 | Transcription factor-like 5 (basic helix-loop-helix). | Sperm-associated antigen 16 protein; Necessary for sperm flagellar function. Plays a role in motile ciliogenesis. May help to recruit STK36 to the cilium or apical surface of the cell to initiate subsequent steps of construction of the central pair apparatus of motile cilia. | 0.461 |