node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Agmat | Aoc1 | ENSMUSP00000040853 | ENSMUSP00000124085 | Agmatinase, mitochondrial. | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | 0.943 |
Agmat | Azin2 | ENSMUSP00000040853 | ENSMUSP00000030581 | Agmatinase, mitochondrial. | Antizyme inhibitor 2; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the t [...] | 0.985 |
Agmat | Doxl1 | ENSMUSP00000040853 | ENSMUSP00000031837 | Agmatinase, mitochondrial. | Amine oxidase. | 0.945 |
Agmat | Doxl2 | ENSMUSP00000040853 | ENSMUSP00000139012 | Agmatinase, mitochondrial. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.945 |
Agmat | Ldc1 | ENSMUSP00000040853 | ENSMUSP00000023884 | Agmatinase, mitochondrial. | Leucine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.975 |
Agmat | Odc1 | ENSMUSP00000040853 | ENSMUSP00000128661 | Agmatinase, mitochondrial. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. | 0.975 |
Agmat | Sat1 | ENSMUSP00000040853 | ENSMUSP00000026318 | Agmatinase, mitochondrial. | Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine (By similarity); Belongs to the acetyltransferase family. | 0.947 |
Agmat | Sat2 | ENSMUSP00000040853 | ENSMUSP00000104296 | Agmatinase, mitochondrial. | Diamine acetyltransferase 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine (By similarity). | 0.911 |
Agmat | Srm | ENSMUSP00000040853 | ENSMUSP00000006611 | Agmatinase, mitochondrial. | Spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3- diaminopropane. Has extremely low activity towards spermidine (By similarity). | 0.980 |
Agmat | Svs1 | ENSMUSP00000040853 | ENSMUSP00000045221 | Agmatinase, mitochondrial. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.943 |
Aoc1 | Agmat | ENSMUSP00000124085 | ENSMUSP00000040853 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Agmatinase, mitochondrial. | 0.943 |
Aoc1 | Azin2 | ENSMUSP00000124085 | ENSMUSP00000030581 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Antizyme inhibitor 2; Antizyme inhibitor (AZI) protein that positively regulates ornithine decarboxylase (ODC) activity and polyamine uptake. AZI is an enzymatically inactive ODC homolog that counteracts the negative effect of ODC antizymes (AZs) OAZ1, OAZ2 and OAZ3 on ODC activity by competing with ODC for antizyme-binding. Inhibits antizyme-dependent ODC degradation and releases ODC monomers from their inactive complex with antizymes, leading to formation of the catalytically active ODC homodimer and restoring polyamine production. Participates in the morphological integrity of the t [...] | 0.515 |
Aoc1 | Doxl1 | ENSMUSP00000124085 | ENSMUSP00000031837 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase. | 0.903 |
Aoc1 | Doxl2 | ENSMUSP00000124085 | ENSMUSP00000139012 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.903 |
Aoc1 | Ldc1 | ENSMUSP00000124085 | ENSMUSP00000023884 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Leucine decarboxylase 1; Belongs to the Orn/Lys/Arg decarboxylase class-II family. | 0.953 |
Aoc1 | Odc1 | ENSMUSP00000124085 | ENSMUSP00000128661 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Ornithine decarboxylase; Catalyzes the first and rate-limiting step of polyamine biosynthesis that converts ornithine into putrescine, which is the precursor for the polyamines, spermidine and spermine. Polyamines are essential for cell proliferation and are implicated in cellular processes, ranging from DNA replication to apoptosis. | 0.953 |
Aoc1 | Sat1 | ENSMUSP00000124085 | ENSMUSP00000026318 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Diamine acetyltransferase 1; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine = spermidine >> spermine > N(1)- acetylspermine > putrescine. This highly regulated enzyme allows a fine attenuation of the intracellular concentration of polyamines. Also involved in the regulation of polyamine transport out of cells. Acts on 1,3-diaminopropane, 1,5-diaminopentane, putrescine, spermidine (forming N(1)- and N(8)-acetylspermidine), spermine, N(1)-acetylspermidine and N(8)-acetylspermidine (By similarity); Belongs to the acetyltransferase family. | 0.921 |
Aoc1 | Sat2 | ENSMUSP00000124085 | ENSMUSP00000104296 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Diamine acetyltransferase 2; Enzyme which catalyzes the acetylation of polyamines. Substrate specificity: norspermidine > spermidine = spermine >> N(1)acetylspermine = putrescine (By similarity). | 0.901 |
Aoc1 | Srm | ENSMUSP00000124085 | ENSMUSP00000006611 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Spermidine synthase; Catalyzes the production of spermidine from putrescine and decarboxylated S-adenosylmethionine (dcSAM). Has a strong preference for putrescine as substrate, and has very low activity towards 1,3- diaminopropane. Has extremely low activity towards spermidine (By similarity). | 0.936 |
Aoc1 | Svs1 | ENSMUSP00000124085 | ENSMUSP00000045221 | Amiloride-sensitive amine oxidase [copper-containing]; Catalyzes the degradation of compounds such as putrescine, histamine, spermine, and spermidine, substances involved in allergic and immune responses, cell proliferation, tissue differentiation, tumor formation, and possibly apoptosis. | Amine oxidase; Belongs to the copper/topaquinone oxidase family. | 0.904 |