node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Btn1a1 | Cidea | ENSMUSP00000041013 | ENSMUSP00000025404 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Cell death activator CIDE-A; Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IG [...] | 0.535 |
Btn1a1 | Csn1s1 | ENSMUSP00000041013 | ENSMUSP00000092225 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate. | 0.643 |
Btn1a1 | Csn1s2a | ENSMUSP00000041013 | ENSMUSP00000075716 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Alpha-S2-casein-like A; Important role in the capacity of milk to transport calcium phosphate. | 0.637 |
Btn1a1 | Csn2 | ENSMUSP00000041013 | ENSMUSP00000143341 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Beta-casein; Important role in determination of the surface properties of the casein micelles. | 0.729 |
Btn1a1 | Csn3 | ENSMUSP00000041013 | ENSMUSP00000108896 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. | 0.642 |
Btn1a1 | Lalba | ENSMUSP00000041013 | ENSMUSP00000023726 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins. | 0.711 |
Btn1a1 | Muc1 | ENSMUSP00000041013 | ENSMUSP00000041963 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Mucin-1 subunit alpha; The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. | 0.619 |
Btn1a1 | Plin2 | ENSMUSP00000041013 | ENSMUSP00000000466 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Perilipin-2; May be involved in development and maintenance of adipose tissue. | 0.927 |
Btn1a1 | Ppl | ENSMUSP00000041013 | ENSMUSP00000039360 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Periplakin; Component of the cornified envelope of keratinocytes. May link the cornified envelope to desmosomes and intermediate filaments. May act as a localization signal in PKB/AKT-mediated signaling. | 0.932 |
Btn1a1 | Xdh | ENSMUSP00000041013 | ENSMUSP00000024866 | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. | 0.984 |
Cidea | Btn1a1 | ENSMUSP00000025404 | ENSMUSP00000041013 | Cell death activator CIDE-A; Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IG [...] | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.535 |
Cidea | Plin2 | ENSMUSP00000025404 | ENSMUSP00000000466 | Cell death activator CIDE-A; Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IG [...] | Perilipin-2; May be involved in development and maintenance of adipose tissue. | 0.730 |
Cidea | Xdh | ENSMUSP00000025404 | ENSMUSP00000024866 | Cell death activator CIDE-A; Binds to lipid droplets and regulates their enlargement, thereby restricting lipolysis and favoring storage. At focal contact sites between lipid droplets, promotes directional net neutral lipid transfer from the smaller to larger lipid droplets. The transfer direction may be driven by the internal pressure difference between the contacting lipid droplet pair and occurs at a lower rate than that promoted by CIDEC. Acts as a CEBPB coactivator in mammary epithelial cells to control the expression of a subset of CEBPB downstream target genes, including ID2, IG [...] | Xanthine dehydrogenase/oxidase; Key enzyme in purine degradation. Catalyzes the oxidation of hypoxanthine to xanthine. Catalyzes the oxidation of xanthine to uric acid. Contributes to the generation of reactive oxygen species. | 0.478 |
Csn1s1 | Btn1a1 | ENSMUSP00000092225 | ENSMUSP00000041013 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate. | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.643 |
Csn1s1 | Csn1s2a | ENSMUSP00000092225 | ENSMUSP00000075716 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate. | Alpha-S2-casein-like A; Important role in the capacity of milk to transport calcium phosphate. | 0.957 |
Csn1s1 | Csn2 | ENSMUSP00000092225 | ENSMUSP00000143341 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate. | Beta-casein; Important role in determination of the surface properties of the casein micelles. | 0.990 |
Csn1s1 | Csn3 | ENSMUSP00000092225 | ENSMUSP00000108896 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate. | Kappa-casein; Kappa-casein stabilizes micelle formation, preventing casein precipitation in milk. | 0.978 |
Csn1s1 | Lalba | ENSMUSP00000092225 | ENSMUSP00000023726 | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate. | Alpha-lactalbumin; Regulatory subunit of lactose synthase, changes the substrate specificity of galactosyltransferase in the mammary gland making glucose a good acceptor substrate for this enzyme. This enables LS to synthesize lactose, the major carbohydrate component of milk. In other tissues, galactosyltransferase transfers galactose onto the N- acetylglucosamine of the oligosaccharide chains in glycoproteins. | 0.958 |
Csn1s2a | Btn1a1 | ENSMUSP00000075716 | ENSMUSP00000041013 | Alpha-S2-casein-like A; Important role in the capacity of milk to transport calcium phosphate. | Butyrophilin subfamily 1 member A1; May function in the secretion of milk-fat droplets. May act as a specific membrane-associated receptor for the association of cytoplasmic droplets with the apical plasma membrane (By similarity). Inhibits the proliferation of CD4 and CD8 T-cells activated by anti-CD3 antibodies, T-cell metabolism and IL2 and IFNG secretion; Belongs to the immunoglobulin superfamily. BTN/MOG family. | 0.637 |
Csn1s2a | Csn1s1 | ENSMUSP00000075716 | ENSMUSP00000092225 | Alpha-S2-casein-like A; Important role in the capacity of milk to transport calcium phosphate. | Alpha-S1-casein; Important role in the capacity of milk to transport calcium phosphate. | 0.957 |