node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arhgap21 | Etl4 | ENSMUSP00000122497 | ENSMUSP00000110274 | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | Sickle tail protein; Required for normal development of intervertebral disks. | 0.447 |
Etl4 | Arhgap21 | ENSMUSP00000110274 | ENSMUSP00000122497 | Sickle tail protein; Required for normal development of intervertebral disks. | Rho GTPase-activating protein 21; Functions as a GTPase-activating protein (GAP) for RHOA and CDC42. Downstream partner of ARF1 which may control Golgi apparatus structure and function. Also required for CTNNA1 recruitment to adherens junctions (By similarity). | 0.447 |
Etl4 | Galnt15 | ENSMUSP00000110274 | ENSMUSP00000022460 | Sickle tail protein; Required for normal development of intervertebral disks. | Polypeptide N-acetylgalactosaminyltransferase 15; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate (By similarity). | 0.433 |
Etl4 | Kcng4 | ENSMUSP00000110274 | ENSMUSP00000056552 | Sickle tail protein; Required for normal development of intervertebral disks. | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. | 0.439 |
Etl4 | Ldlrad3 | ENSMUSP00000110274 | ENSMUSP00000054134 | Sickle tail protein; Required for normal development of intervertebral disks. | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. | 0.410 |
Etl4 | Lrpap1 | ENSMUSP00000110274 | ENSMUSP00000030986 | Sickle tail protein; Required for normal development of intervertebral disks. | Alpha-2-macroglobulin receptor-associated protein; Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. | 0.478 |
Etl4 | Plxdc2 | ENSMUSP00000110274 | ENSMUSP00000028081 | Sickle tail protein; Required for normal development of intervertebral disks. | Plexin domain-containing protein 2; May play a role in tumor angiogenesis. Belongs to the plexin family. | 0.529 |
Etl4 | Specc1l | ENSMUSP00000110274 | ENSMUSP00000101061 | Sickle tail protein; Required for normal development of intervertebral disks. | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity); Belongs to the cytospin-A family. | 0.407 |
Etl4 | Tmem270 | ENSMUSP00000110274 | ENSMUSP00000144496 | Sickle tail protein; Required for normal development of intervertebral disks. | Transmembrane protein 270. | 0.467 |
Galnt15 | Etl4 | ENSMUSP00000022460 | ENSMUSP00000110274 | Polypeptide N-acetylgalactosaminyltransferase 15; Catalyzes the initial reaction in O-linked oligosaccharide biosynthesis, the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Although it displays a much weaker activity toward all substrates tested compared to GALNT2, it is able to transfer up to seven GalNAc residues to the Muc5AC peptide, suggesting that it can fill vicinal Thr/Ser residues in cooperation with other GALNT proteins. Prefers Muc1a as substrate (By similarity). | Sickle tail protein; Required for normal development of intervertebral disks. | 0.433 |
Kcng4 | Etl4 | ENSMUSP00000056552 | ENSMUSP00000110274 | Potassium voltage-gated channel subfamily G member 4; Potassium channel subunit that does not form functional channels by itself. Can form functional heterotetrameric channels with KCNB1; modulates the delayed rectifier voltage-gated potassium channel activation and deactivation rates of KCNB1. Belongs to the potassium channel family. G (TC 1.A.1.2) subfamily. Kv6.4/KCNG4 sub-subfamily. | Sickle tail protein; Required for normal development of intervertebral disks. | 0.439 |
Ldlrad3 | Etl4 | ENSMUSP00000054134 | ENSMUSP00000110274 | Low-density lipoprotein receptor class A domain-containing protein 3; May influence APP processing, resulting in a decrease in sAPP-alpha production and increased amyloidogenic P3 peptide production. | Sickle tail protein; Required for normal development of intervertebral disks. | 0.410 |
Lrpap1 | Etl4 | ENSMUSP00000030986 | ENSMUSP00000110274 | Alpha-2-macroglobulin receptor-associated protein; Molecular chaperone for LDL receptor-related proteins that may regulate their ligand binding activity along the secretory pathway. | Sickle tail protein; Required for normal development of intervertebral disks. | 0.478 |
Plxdc2 | Etl4 | ENSMUSP00000028081 | ENSMUSP00000110274 | Plexin domain-containing protein 2; May play a role in tumor angiogenesis. Belongs to the plexin family. | Sickle tail protein; Required for normal development of intervertebral disks. | 0.529 |
Specc1l | Etl4 | ENSMUSP00000101061 | ENSMUSP00000110274 | Cytospin-A; Involved in cytokinesis and spindle organization. May play a role in actin cytoskeleton organization and microtubule stabilization and hence required for proper cell adhesion and migration (By similarity); Belongs to the cytospin-A family. | Sickle tail protein; Required for normal development of intervertebral disks. | 0.407 |
Tmem270 | Etl4 | ENSMUSP00000144496 | ENSMUSP00000110274 | Transmembrane protein 270. | Sickle tail protein; Required for normal development of intervertebral disks. | 0.467 |