node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Actr2 | Coro2b | ENSMUSP00000000137 | ENSMUSP00000041826 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | 0.486 |
Actr2 | Vcl | ENSMUSP00000000137 | ENSMUSP00000022369 | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity); Belongs to the vinculin/alpha-catenin family. | 0.742 |
Aldh18a1 | Coro2b | ENSMUSP00000025979 | ENSMUSP00000041826 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | 0.458 |
Aldh18a1 | Dut | ENSMUSP00000025979 | ENSMUSP00000080767 | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | Deoxyuridine triphosphatase. | 0.452 |
Ankrd34b | Coro2b | ENSMUSP00000054330 | ENSMUSP00000041826 | Ankyrin repeat domain-containing protein 34B; Belongs to the ANKRD34 family. | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | 0.481 |
Coro2b | Actr2 | ENSMUSP00000041826 | ENSMUSP00000000137 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Actin-related protein 2; ATP-binding component of the Arp2/3 complex, a multiprotein complex that mediates actin polymerization upon stimulation by nucleation-promoting factor (NPF). The Arp2/3 complex mediates the formation of branched actin networks in the cytoplasm, providing the force for cell motility. Seems to contact the pointed end of the daughter actin filament. In addition to its role in the cytoplasmic cytoskeleton, the Arp2/3 complex also promotes actin polymerization in the nucleus, thereby regulating gene transcription and repair of damaged DNA. The Arp2/3 complex promote [...] | 0.486 |
Coro2b | Aldh18a1 | ENSMUSP00000041826 | ENSMUSP00000025979 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.458 |
Coro2b | Ankrd34b | ENSMUSP00000041826 | ENSMUSP00000054330 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Ankyrin repeat domain-containing protein 34B; Belongs to the ANKRD34 family. | 0.481 |
Coro2b | Dut | ENSMUSP00000041826 | ENSMUSP00000080767 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Deoxyuridine triphosphatase. | 0.552 |
Coro2b | Gmppa | ENSMUSP00000041826 | ENSMUSP00000109214 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Mannose-1-phosphate guanyltransferase alpha; May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose; Belongs to the transferase hexapeptide repeat family. | 0.454 |
Coro2b | Homer2 | ENSMUSP00000041826 | ENSMUSP00000146787 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Homer protein homolog 2; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing. Negatively regula [...] | 0.432 |
Coro2b | Klhl8 | ENSMUSP00000041826 | ENSMUSP00000031254 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Kelch-like protein 8; Substrate-specific adapter of a BCR (BTB-CUL3-RBX1) E3 ubiquitin ligase complex required for The BCR(KLHL8) ubiquitin ligase complex mediates ubiquitination and degradation of RAPSN. | 0.450 |
Coro2b | Sept3 | ENSMUSP00000041826 | ENSMUSP00000023095 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Neuronal-specific septin-3; Filament-forming cytoskeletal GTPase (By similarity). May play a role in cytokinesis (Potential). | 0.505 |
Coro2b | Srcin1 | ENSMUSP00000041826 | ENSMUSP00000103222 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity). | 0.432 |
Coro2b | Vcl | ENSMUSP00000041826 | ENSMUSP00000022369 | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | Vinculin; Actin filament (F-actin)-binding protein involved in cell- matrix adhesion and cell-cell adhesion. Regulates cell-surface E- cadherin expression and potentiates mechanosensing by the E-cadherin complex. May also play important roles in cell morphology and locomotion (By similarity); Belongs to the vinculin/alpha-catenin family. | 0.617 |
Dut | Aldh18a1 | ENSMUSP00000080767 | ENSMUSP00000025979 | Deoxyuridine triphosphatase. | Delta-1-pyrroline-5-carboxylate synthase; Bifunctional enzyme that converts glutamate to glutamate 5- semialdehyde, an intermediate in the biosynthesis of proline, ornithine and arginine; In the C-terminal section; belongs to the gamma-glutamyl phosphate reductase family. | 0.452 |
Dut | Coro2b | ENSMUSP00000080767 | ENSMUSP00000041826 | Deoxyuridine triphosphatase. | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | 0.552 |
Gmppa | Coro2b | ENSMUSP00000109214 | ENSMUSP00000041826 | Mannose-1-phosphate guanyltransferase alpha; May serve as a regulatory subunit and allow allosteric feedback inhibition of GMPPB by GDP-mannose; Belongs to the transferase hexapeptide repeat family. | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | 0.454 |
Homer2 | Coro2b | ENSMUSP00000146787 | ENSMUSP00000041826 | Homer protein homolog 2; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing. Negatively regula [...] | Coronin-2B; May play a role in the reorganization of neuronal actin structure. | 0.432 |
Homer2 | Srcin1 | ENSMUSP00000146787 | ENSMUSP00000103222 | Homer protein homolog 2; Postsynaptic density scaffolding protein. Binds and cross- links cytoplasmic regions of GRM1, GRM5, ITPR1, DNM3, RYR1, RYR2, SHANK1 and SHANK3. By physically linking GRM1 and GRM5 with ER- associated ITPR1 receptors, it aids the coupling of surface receptors to intracellular calcium release. May also couple GRM1 to PI3 kinase through its interaction with AGAP2 (By similarity). Isoforms can be differently regulated and may play an important role in maintaining the plasticity at glutamatergic synapses (By similarity) Required for normal hearing. Negatively regula [...] | SRC kinase signaling inhibitor 1; Acts as a negative regulator of SRC by activating CSK which inhibits SRC activity and downstream signaling, leading to impaired cell spreading and migration. Regulates dendritic spine morphology. Involved in calcium-dependent exocytosis. May play a role in neurotransmitter release or synapse maintenance (By similarity). | 0.416 |