node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arv1 | Tex2 | ENSMUSP00000034463 | ENSMUSP00000041985 | Protein ARV1; Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes ; Belongs to the ARV1 family. | Testis-expressed protein 2. | 0.515 |
C2cd2l | Pdzd8 | ENSMUSP00000065233 | ENSMUSP00000096880 | Phospholipid transfer protein C2CD2L; Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two [...] | PDZ domain-containing protein 8; Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons. | 0.444 |
C2cd2l | Tex2 | ENSMUSP00000065233 | ENSMUSP00000041985 | Phospholipid transfer protein C2CD2L; Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two [...] | Testis-expressed protein 2. | 0.507 |
Lrrc40 | Tex2 | ENSMUSP00000071956 | ENSMUSP00000041985 | Leucine-rich repeat-containing protein 40. | Testis-expressed protein 2. | 0.554 |
Nckap5l | Tex2 | ENSMUSP00000023747 | ENSMUSP00000041985 | Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L- mediated microtubule bundle formation. | Testis-expressed protein 2. | 0.592 |
Nol4 | Tex2 | ENSMUSP00000130950 | ENSMUSP00000041985 | Nucleolar protein 4. | Testis-expressed protein 2. | 0.498 |
Pdzd8 | C2cd2l | ENSMUSP00000096880 | ENSMUSP00000065233 | PDZ domain-containing protein 8; Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons. | Phospholipid transfer protein C2CD2L; Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two [...] | 0.444 |
Pdzd8 | Tex2 | ENSMUSP00000096880 | ENSMUSP00000041985 | PDZ domain-containing protein 8; Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons. | Testis-expressed protein 2. | 0.519 |
Pi4ka | Syngr1 | ENSMUSP00000156049 | ENSMUSP00000009727 | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity. Belongs to the synaptogyrin family. | 0.454 |
Pi4ka | Tex2 | ENSMUSP00000156049 | ENSMUSP00000041985 | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | Testis-expressed protein 2. | 0.549 |
Rhoa | Tex2 | ENSMUSP00000007959 | ENSMUSP00000041985 | Transforming protein RhoA; Small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. Mainly associated with cytoskeleton organization, in active state binds to a variety of effector proteins to regulate cellular responses such cytoskeletal dynamics, cell migration and cell cycle. Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis (By similarity). [...] | Testis-expressed protein 2. | 0.510 |
Syngr1 | Pi4ka | ENSMUSP00000009727 | ENSMUSP00000156049 | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity. Belongs to the synaptogyrin family. | Phosphatidylinositol 4-kinase alpha; Acts on phosphatidylinositol (PtdIns) in the first committed step in the production of the second messenger inositol-1,4,5,- trisphosphate; Belongs to the PI3/PI4-kinase family. Type III PI4K subfamily. | 0.454 |
Syngr1 | Tex2 | ENSMUSP00000009727 | ENSMUSP00000041985 | Synaptogyrin-1; May play a role in regulated exocytosis. Modulates the localization of synaptophysin/SYP into synaptic-like microvesicles and may therefore play a role in synaptic-like microvesicle formation and/or maturation (By similarity). Involved in the regulation of short- term and long-term synaptic plasticity. Belongs to the synaptogyrin family. | Testis-expressed protein 2. | 0.521 |
Tbc1d16 | Tex2 | ENSMUSP00000048516 | ENSMUSP00000041985 | TBC1 domain family, member 16. | Testis-expressed protein 2. | 0.499 |
Tex2 | Arv1 | ENSMUSP00000041985 | ENSMUSP00000034463 | Testis-expressed protein 2. | Protein ARV1; Plays a role as a mediator in the endoplasmic reticulum (ER) cholesterol and bile acid homeostasis. Participates in sterol transport out of the ER and distribution into plasma membranes ; Belongs to the ARV1 family. | 0.515 |
Tex2 | C2cd2l | ENSMUSP00000041985 | ENSMUSP00000065233 | Testis-expressed protein 2. | Phospholipid transfer protein C2CD2L; Lipid-binding protein that transports phosphatidylinositol, the precursor of phosphatidylinositol 4,5-bisphosphate (PI(4,5)P2), from its site of synthesis in the endoplasmic reticulum to the cell membrane (By similarity). It thereby maintains the pool of cell membrane phosphoinositides, which are degraded during phospholipase C (PLC) signaling (By similarity). Plays a key role in the coordination of Ca(2+) and phosphoinositide signaling: localizes to sites of contact between the endoplasmic reticulum and the cell membrane, where it tethers the two [...] | 0.507 |
Tex2 | Lrrc40 | ENSMUSP00000041985 | ENSMUSP00000071956 | Testis-expressed protein 2. | Leucine-rich repeat-containing protein 40. | 0.554 |
Tex2 | Nckap5l | ENSMUSP00000041985 | ENSMUSP00000023747 | Testis-expressed protein 2. | Nck-associated protein 5-like; Regulates microtubule organization and stabilization. Promotes microtubule growth and bundling formation and stabilizes microtubules by increasing intense acetylation of microtubules. Both tubulin-binding and homodimer formation are required for NCKAP5L- mediated microtubule bundle formation. | 0.592 |
Tex2 | Nol4 | ENSMUSP00000041985 | ENSMUSP00000130950 | Testis-expressed protein 2. | Nucleolar protein 4. | 0.498 |
Tex2 | Pdzd8 | ENSMUSP00000041985 | ENSMUSP00000096880 | Testis-expressed protein 2. | PDZ domain-containing protein 8; Molecular tethering protein that connects endoplasmic reticulum and mitochondria membranes. PDZD8-dependent endoplasmic reticulum-mitochondria membrane tethering is essential for endoplasmic reticulum-mitochondria Ca(2+) transfer. In neurons, involved in the regulation of dendritic Ca(2+) dynamics by regulating mitochondrial Ca(2+) uptake in neurons. | 0.519 |