node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
AW551984 | Espnl | ENSMUSP00000042582 | ENSMUSP00000086294 | Expressed sequence AW551984. | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | 0.411 |
AW551984 | Hpf1 | ENSMUSP00000042582 | ENSMUSP00000047235 | Expressed sequence AW551984. | Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity o [...] | 0.436 |
AW551984 | Lrrc30 | ENSMUSP00000042582 | ENSMUSP00000094893 | Expressed sequence AW551984. | Leucine-rich repeat-containing protein 30. | 0.491 |
AW551984 | Olfr523 | ENSMUSP00000042582 | ENSMUSP00000052678 | Expressed sequence AW551984. | Olfactory receptor. | 0.606 |
AW551984 | Parg | ENSMUSP00000042582 | ENSMUSP00000022470 | Expressed sequence AW551984. | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP- ribose and ADP-ribosylated residues, leaving proteins that are mono- ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental [...] | 0.431 |
AW551984 | Xrcc5 | ENSMUSP00000042582 | ENSMUSP00000027379 | Expressed sequence AW551984. | X-ray repair cross-complementing protein 5; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] | 0.426 |
AW551984 | Xrcc6 | ENSMUSP00000042582 | ENSMUSP00000097968 | Expressed sequence AW551984. | X-ray repair cross-complementing protein 6; Single-stranded DNA-dependent ATP-dependent helicase. Has a role in chromosome translocation. The DNA helicase II complex binds preferentially to fork-like ends of double-stranded DNA in a cell cycle-dependent manner. It works in the 3'-5' direction. Binding to DNA may be mediated by XRCC6. Involved in DNA non-homologous end joining (NHEJ) required for double-strand break repair and V(D)J recombination. The XRCC5/6 dimer acts as regulatory subunit of the DNA-dependent protein kinase complex DNA-PK by increasing the affinity of the catalytic s [...] | 0.406 |
AW551984 | Zcchc12 | ENSMUSP00000042582 | ENSMUSP00000110911 | Expressed sequence AW551984. | Zinc finger CCHC domain-containing protein 12; Transcriptional coactivator in the bone morphogenetic protein (BMP)-signaling pathway. It positively modulates BMP signaling by interacting with SMAD1 and associating with CBP in the transcription complex. It contributes to the BMP-induced enhancement of cholinergic- neuron-specific gene expression. | 0.515 |
Espnl | AW551984 | ENSMUSP00000086294 | ENSMUSP00000042582 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | Expressed sequence AW551984. | 0.411 |
Espnl | Lrrc30 | ENSMUSP00000086294 | ENSMUSP00000094893 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | Leucine-rich repeat-containing protein 30. | 0.695 |
Espnl | Olfr523 | ENSMUSP00000086294 | ENSMUSP00000052678 | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | Olfactory receptor. | 0.491 |
Hpf1 | AW551984 | ENSMUSP00000047235 | ENSMUSP00000042582 | Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity o [...] | Expressed sequence AW551984. | 0.436 |
Hpf1 | Parg | ENSMUSP00000047235 | ENSMUSP00000022470 | Histone PARylation factor 1; Acts as a cofactor for serine ADP-ribosylation by conferring serine specificity on PARP1 and PARP2: interacts with PARP1 and PARP2 and is able to change amino acid specificity toward serine. Promotes histone serine ADP-ribosylation in response to DNA damage, limiting DNA damage-induced PARP1 hyper-automodification, and ensuring genome stability. Serine ADP-ribosylation of proteins constitutes the primary form of ADP-ribosylation of proteins in response to DNA damage. HPF1 also promotes tyrosine ADP-ribosylation, probably by conferring tyrosine specificity o [...] | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP- ribose and ADP-ribosylated residues, leaving proteins that are mono- ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental [...] | 0.726 |
Lrrc30 | AW551984 | ENSMUSP00000094893 | ENSMUSP00000042582 | Leucine-rich repeat-containing protein 30. | Expressed sequence AW551984. | 0.491 |
Lrrc30 | Espnl | ENSMUSP00000094893 | ENSMUSP00000086294 | Leucine-rich repeat-containing protein 30. | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | 0.695 |
Lrrc30 | Olfr523 | ENSMUSP00000094893 | ENSMUSP00000052678 | Leucine-rich repeat-containing protein 30. | Olfactory receptor. | 0.643 |
Olfr523 | AW551984 | ENSMUSP00000052678 | ENSMUSP00000042582 | Olfactory receptor. | Expressed sequence AW551984. | 0.606 |
Olfr523 | Espnl | ENSMUSP00000052678 | ENSMUSP00000086294 | Olfactory receptor. | Espin-like protein; Binds to but does not cross-link actin. Required for the formation and maintenance of inner ear hair cell stereocilia and staircase formation. Essential for normal hearing. | 0.491 |
Olfr523 | Lrrc30 | ENSMUSP00000052678 | ENSMUSP00000094893 | Olfactory receptor. | Leucine-rich repeat-containing protein 30. | 0.643 |
Parg | AW551984 | ENSMUSP00000022470 | ENSMUSP00000042582 | Poly(ADP-ribose) glycohydrolase; Poly(ADP-ribose) glycohydrolase that degrades poly(ADP- ribose) by hydrolyzing the ribose-ribose bonds present in poly(ADP- ribose). PARG acts both as an endo- and exoglycosidase, releasing poly(ADP-ribose) of different length as well as ADP-ribose monomers. It is however unable to cleave the ester bond between the terminal ADP- ribose and ADP-ribosylated residues, leaving proteins that are mono- ADP-ribosylated. Poly(ADP-ribose) is synthesized after DNA damage is only present transiently and is rapidly degraded by PARG. Required to prevent detrimental [...] | Expressed sequence AW551984. | 0.431 |