node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Gja1 | Sgsm3 | ENSMUSP00000151620 | ENSMUSP00000122543 | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization [...] | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.588 |
Hhipl2 | Sgsm3 | ENSMUSP00000070719 | ENSMUSP00000122543 | HHIP-like protein 2; Belongs to the HHIP family. | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.554 |
Ino80e | Sgsm3 | ENSMUSP00000049851 | ENSMUSP00000122543 | INO80 complex subunit E. | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.577 |
Nubpl | Otud3 | ENSMUSP00000044292 | ENSMUSP00000095441 | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity). | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | 0.401 |
Nubpl | Sgsm3 | ENSMUSP00000044292 | ENSMUSP00000122543 | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity). | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.517 |
Nubpl | Zmym4 | ENSMUSP00000044292 | ENSMUSP00000101714 | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity). | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.511 |
Otud3 | Nubpl | ENSMUSP00000095441 | ENSMUSP00000044292 | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity). | 0.401 |
Otud3 | Sgsm3 | ENSMUSP00000095441 | ENSMUSP00000122543 | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.544 |
Otud3 | Ufsp2 | ENSMUSP00000095441 | ENSMUSP00000034051 | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity); Belongs to the peptidase C78 family. | 0.501 |
Otud3 | Zmym4 | ENSMUSP00000095441 | ENSMUSP00000101714 | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | Zinc finger MYM-type protein 4; Plays a role in the regulation of cell morphology and cytoskeletal organization. | 0.543 |
Sgsm1 | Sgsm3 | ENSMUSP00000046544 | ENSMUSP00000122543 | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family. | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.668 |
Sgsm2 | Sgsm3 | ENSMUSP00000050496 | ENSMUSP00000122543 | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation ; Belongs to the RUTBC family. | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | 0.693 |
Sgsm3 | Gja1 | ENSMUSP00000122543 | ENSMUSP00000151620 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | Gap junction alpha-1 protein; Gap junction protein that acts as a regulator of bladder capacity. A gap junction consists of a cluster of closely packed pairs of transmembrane channels, the connexons, through which materials of low MW diffuse from one cell to a neighboring cell. Negative regulator of bladder functional capacity: acts by enhancing intercellular electrical and chemical transmission, thus sensitizing bladder muscles to cholinergic neural stimuli and causing them to contract. May play a role in cell growth inhibition through the regulation of NOV expression and localization [...] | 0.588 |
Sgsm3 | Hhipl2 | ENSMUSP00000122543 | ENSMUSP00000070719 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | HHIP-like protein 2; Belongs to the HHIP family. | 0.554 |
Sgsm3 | Ino80e | ENSMUSP00000122543 | ENSMUSP00000049851 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | INO80 complex subunit E. | 0.577 |
Sgsm3 | Nubpl | ENSMUSP00000122543 | ENSMUSP00000044292 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | Iron-sulfur protein NUBPL; Required for the assembly of the mitochondrial membrane respiratory chain NADH dehydrogenase (Complex I). May deliver of one or more Fe-S clusters to complex I subunits (By similarity). | 0.517 |
Sgsm3 | Otud3 | ENSMUSP00000122543 | ENSMUSP00000095441 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | OTU domain-containing protein 3; Deubiquitinating enzyme that hydrolyzes 'Lys-6'- and 'Lys- 11'-linked polyubiquitin. Also hydrolyzes heterotypic (mixed and branched) and homotypic chains (By similarity). | 0.544 |
Sgsm3 | Sgsm1 | ENSMUSP00000122543 | ENSMUSP00000046544 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | Small G protein signaling modulator 1; Interacts with numerous Rab family members, functioning as Rab effector for some, and as GTPase activator for others. Promotes GTP hydrolysis by RAB34 and RAB36. Probably functions as GTPase effector with RAB9A and RAB9B; does not stimulate GTP hydrolysis with RAB9A and RAB9B; Belongs to the RUTBC family. | 0.668 |
Sgsm3 | Sgsm2 | ENSMUSP00000122543 | ENSMUSP00000050496 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | Small G protein signaling modulator 2; Possesses GTPase activator activity towards RAB32, RAB33B and RAB38. Regulates the trafficking of melanogenic enzymes TYR, TYRP1 and DCT/TYRP2 to melanosomes in melanocytes by inactivating RAB32 and RAB38. Inhibits RAB32 and RAB38 activation both directly by promoting their GTPase activity and indirectly by disrupting the RAB9A-HPS4 interaction which is required for RAB32/38 activation ; Belongs to the RUTBC family. | 0.693 |
Sgsm3 | Ufsp2 | ENSMUSP00000122543 | ENSMUSP00000034051 | Small G protein signaling modulator 3; May play a cooperative role in NF2-mediated growth suppression of cells. | Ufm1-specific protease 2; Thiol protease which recognizes and hydrolyzes the peptide bond at the C-terminal Gly of UFM1, a ubiquitin-like modifier protein bound to a number of target proteins. Does not hydrolyze SUMO1 or ISG15 ubiquitin-like proteins. Through TRIP4 deufmylation may regulate intracellular nuclear receptors transactivation and thereby regulate cell proliferation and differentiation (By similarity); Belongs to the peptidase C78 family. | 0.519 |