node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
9830107B12Rik | Trem1 | ENSMUSP00000070138 | ENSMUSP00000038636 | RIKEN cDNA 9830107B12 gene. | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | 0.456 |
9830107B12Rik | Trem3 | ENSMUSP00000070138 | ENSMUSP00000044478 | RIKEN cDNA 9830107B12 gene. | Triggering receptor expressed on myeloid cells 3; Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response. | 0.618 |
9830107B12Rik | Treml1 | ENSMUSP00000070138 | ENSMUSP00000153300 | RIKEN cDNA 9830107B12 gene. | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. | 0.554 |
9830107B12Rik | Treml2 | ENSMUSP00000070138 | ENSMUSP00000156527 | RIKEN cDNA 9830107B12 gene. | Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity). | 0.487 |
A530064D06Rik | Trem2 | ENSMUSP00000055935 | ENSMUSP00000108863 | Triggering receptor expressed in myeloid cells 4. | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as [...] | 0.479 |
A530064D06Rik | Trem3 | ENSMUSP00000055935 | ENSMUSP00000044478 | Triggering receptor expressed in myeloid cells 4. | Triggering receptor expressed on myeloid cells 3; Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response. | 0.713 |
A530064D06Rik | Tyrobp | ENSMUSP00000055935 | ENSMUSP00000032800 | Triggering receptor expressed in myeloid cells 4. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. TYROBP is tyrosine- phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation. Also has an inhibitory role in some cells. Non-covalently associates with activating receptors of the CD300 family to mediate cell activation [...] | 0.757 |
Clec5a | Trem1 | ENSMUSP00000121848 | ENSMUSP00000038636 | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | 0.772 |
Clec5a | Trem2 | ENSMUSP00000121848 | ENSMUSP00000108863 | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as [...] | 0.537 |
Clec5a | Trem3 | ENSMUSP00000121848 | ENSMUSP00000044478 | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. | Triggering receptor expressed on myeloid cells 3; Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response. | 0.538 |
Clec5a | Tyrobp | ENSMUSP00000121848 | ENSMUSP00000032800 | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. | TYRO protein tyrosine kinase-binding protein; Adapter protein which non-covalently associates with activating receptors found on the surface of a variety of immune cells to mediate signaling and cell activation following ligand binding by the receptors. TYROBP is tyrosine- phosphorylated in the ITAM domain following ligand binding by the associated receptors which leads to activation of additional tyrosine kinases and subsequent cell activation. Also has an inhibitory role in some cells. Non-covalently associates with activating receptors of the CD300 family to mediate cell activation [...] | 0.996 |
Mmp8 | Trem1 | ENSMUSP00000018765 | ENSMUSP00000038636 | Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution. | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | 0.479 |
Mmp8 | Trem3 | ENSMUSP00000018765 | ENSMUSP00000044478 | Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution. | Triggering receptor expressed on myeloid cells 3; Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response. | 0.570 |
Trem1 | 9830107B12Rik | ENSMUSP00000038636 | ENSMUSP00000070138 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | RIKEN cDNA 9830107B12 gene. | 0.456 |
Trem1 | Clec5a | ENSMUSP00000038636 | ENSMUSP00000121848 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | C-type lectin domain family 5 member A; Functions as a positive regulator of osteoclastogenesis. Cell surface receptor that signals via TYROBP. Regulates inflammatory responses. | 0.772 |
Trem1 | Mmp8 | ENSMUSP00000038636 | ENSMUSP00000018765 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | Neutrophil collagenase; Can degrade fibrillar type I, II, and III collagens. May play a role in the degradation of collagen fibers during uterine involution. | 0.479 |
Trem1 | Trem2 | ENSMUSP00000038636 | ENSMUSP00000108863 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | Triggering receptor expressed on myeloid cells 2; Forms a receptor signaling complex with TYROBP which mediates signaling and cell activation following ligand binding. Acts as a receptor for amyloid-beta protein 42, a cleavage product of the amyloid-beta precursor protein APP, and mediates its uptake and degradation by microglia. Binding to amyloid-beta 42 mediates microglial activation, proliferation, migration, apoptosis and expression of pro- inflammatory cytokines, such as IL6R and CCL3, and the anti- inflammatory cytokine ARG1. Acts as a receptor for lipoprotein particles such as [...] | 0.935 |
Trem1 | Trem3 | ENSMUSP00000038636 | ENSMUSP00000044478 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | Triggering receptor expressed on myeloid cells 3; Forms a receptor signaling complex with TYROBP/DAP12 which mediates activation of macrophages as part of the innate immune response. | 0.542 |
Trem1 | Treml1 | ENSMUSP00000038636 | ENSMUSP00000153300 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | Trem-like transcript 1 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. | 0.832 |
Trem1 | Treml2 | ENSMUSP00000038636 | ENSMUSP00000156527 | Triggering receptor expressed on myeloid cells 1; Stimulates neutrophil and monocyte-mediated inflammatory responses. Triggers release of pro-inflammatory chemokines and cytokines, as well as increased surface expression of cell activation markers. Amplifier of inflammatory responses that are triggered by bacterial and fungal infections and is a crucial mediator of septic shock (By similarity). | Trem-like transcript 2 protein; Cell surface receptor that may play a role in the innate and adaptive immune response. Acts as a counter-receptor for CD276 and interaction with CD276 on T-cells enhances T-cell activation (By similarity). | 0.808 |