node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Bloc1s5 | Fam102a | ENSMUSP00000036614 | ENSMUSP00000044731 | Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | Protein FAM102A; May play a role in estrogen action. | 0.447 |
Fam102a | Bloc1s5 | ENSMUSP00000044731 | ENSMUSP00000036614 | Protein FAM102A; May play a role in estrogen action. | Biogenesis of lysosome-related organelles complex 1 subunit 5; Component of the BLOC-1 complex, a complex that is required for normal biogenesis of lysosome-related organelles (LRO), such as platelet dense granules and melanosomes. In concert with the AP-3 complex, the BLOC-1 complex is required to target membrane protein cargos into vesicles assembled at cell bodies for delivery into neurites and nerve terminals. The BLOC-1 complex, in association with SNARE proteins, is also proposed to be involved in neurite extension. Plays a role in intracellular vesicle trafficking. | 0.447 |
Fam102a | Gpsm2 | ENSMUSP00000044731 | ENSMUSP00000029482 | Protein FAM102A; May play a role in estrogen action. | G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. Belongs to the GPSM family. | 0.453 |
Fam102a | Nell2 | ENSMUSP00000044731 | ENSMUSP00000131665 | Protein FAM102A; May play a role in estrogen action. | Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). | 0.417 |
Fam102a | Pip5kl1 | ENSMUSP00000044731 | ENSMUSP00000051282 | Protein FAM102A; May play a role in estrogen action. | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. | 0.488 |
Fam102a | Polr3c | ENSMUSP00000044731 | ENSMUSP00000122435 | Protein FAM102A; May play a role in estrogen action. | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during i [...] | 0.479 |
Fam102a | Rpl32 | ENSMUSP00000044731 | ENSMUSP00000145350 | Protein FAM102A; May play a role in estrogen action. | 60S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. | 0.406 |
Fam102a | Rps15 | ENSMUSP00000044731 | ENSMUSP00000069004 | Protein FAM102A; May play a role in estrogen action. | 40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. | 0.405 |
Fam102a | Sec61g | ENSMUSP00000044731 | ENSMUSP00000132348 | Protein FAM102A; May play a role in estrogen action. | Protein transport protein Sec61 subunit gamma; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). | 0.612 |
Fam102a | Skap1 | ENSMUSP00000044731 | ENSMUSP00000099443 | Protein FAM102A; May play a role in estrogen action. | Src kinase-associated phosphoprotein 1; Positively regulates T-cell receptor signaling by enhancing the MAP kinase pathway (By similarity). Required for optimal conjugation between T-cells and antigen-presenting cells by promoting the clustering of integrin ITGAL on the surface of T-cells (By similarity). May be involved in high affinity immunoglobulin epsilon receptor signaling in mast cells. Belongs to the SKAP family. | 0.409 |
Fam102a | Slamf8 | ENSMUSP00000044731 | ENSMUSP00000067527 | Protein FAM102A; May play a role in estrogen action. | SLAM family member 8; May play a role in B-lineage commitment and/or modulation of signaling through the B-cell receptor. | 0.412 |
Gpsm2 | Fam102a | ENSMUSP00000029482 | ENSMUSP00000044731 | G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. Belongs to the GPSM family. | Protein FAM102A; May play a role in estrogen action. | 0.453 |
Gpsm2 | Pip5kl1 | ENSMUSP00000029482 | ENSMUSP00000051282 | G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. Belongs to the GPSM family. | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. | 0.453 |
Nell2 | Fam102a | ENSMUSP00000131665 | ENSMUSP00000044731 | Protein kinase C-binding protein NELL2; Required for neuron survival through the modulation of MAPK pathways (By similarity). Involved in the regulation of hypothalamic GNRH secretion and the control of puberty (By similarity). | Protein FAM102A; May play a role in estrogen action. | 0.417 |
Pip5kl1 | Fam102a | ENSMUSP00000051282 | ENSMUSP00000044731 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. | Protein FAM102A; May play a role in estrogen action. | 0.488 |
Pip5kl1 | Gpsm2 | ENSMUSP00000051282 | ENSMUSP00000029482 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. | G-protein-signaling modulator 2; Plays an important role in mitotic spindle pole organization via its interaction with NUMA1. Required for cortical dynein-dynactin complex recruitment during metaphase (By similarity). Plays a role in metaphase spindle orientation (By similarity). Plays an important role in asymmetric cell divisions. Has guanine nucleotide dissociation inhibitor (GDI) activity towards G(i) alpha proteins, such as GNAI1 and GNAI3, and thereby regulates their activity. Belongs to the GPSM family. | 0.453 |
Pip5kl1 | Rpl32 | ENSMUSP00000051282 | ENSMUSP00000145350 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. | 60S ribosomal protein L32; Belongs to the eukaryotic ribosomal protein eL32 family. | 0.406 |
Pip5kl1 | Rps15 | ENSMUSP00000051282 | ENSMUSP00000069004 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. | 40S ribosomal protein S15; Belongs to the universal ribosomal protein uS19 family. | 0.404 |
Pip5kl1 | Sec61g | ENSMUSP00000051282 | ENSMUSP00000132348 | Phosphatidylinositol 4-phosphate 5-kinase-like protein 1; May act as a scaffold to localize and regulate type I PI(4)P 5-kinases to specific compartments within the cell, where they generate PI(4,5)P2 for actin nucleation, signaling and scaffold protein recruitment and conversion to PI(3,4,5)P3. | Protein transport protein Sec61 subunit gamma; Component of SEC61 channel-forming translocon complex that mediates transport of signal peptide-containing precursor polypeptides across endoplasmic reticulum (ER). | 0.612 |
Polr3c | Fam102a | ENSMUSP00000122435 | ENSMUSP00000044731 | DNA-directed RNA polymerase III subunit RPC3; DNA-dependent RNA polymerase catalyzes the transcription of DNA into RNA using the four ribonucleoside triphosphates as substrates. Specific core component of RNA polymerase III which synthesizes small RNAs, such as 5S rRNA and tRNAs. May direct with other members of the subcomplex RNA Pol III binding to the TFIIIB-DNA complex via the interactions between TFIIIB and POLR3F. May be involved either in the recruitment and stabilization of the subcomplex within RNA polymerase III, or in stimulating catalytic functions of other subunits during i [...] | Protein FAM102A; May play a role in estrogen action. | 0.479 |