node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Avl9 | Dennd6a | ENSMUSP00000031805 | ENSMUSP00000039361 | Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity). | 0.652 |
Avl9 | Dennd6b | ENSMUSP00000031805 | ENSMUSP00000077978 | Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35 (By similarity); Belongs to the DENND6 family. | 0.572 |
Avl9 | E330009J07Rik | ENSMUSP00000031805 | ENSMUSP00000045103 | Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | 0.665 |
Avl9 | Fam45a | ENSMUSP00000031805 | ENSMUSP00000025957 | Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. | DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP- bound form. | 0.670 |
Avl9 | Ric1 | ENSMUSP00000031805 | ENSMUSP00000043437 | Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.704 |
Dennd6a | Avl9 | ENSMUSP00000039361 | ENSMUSP00000031805 | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity). | Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. | 0.652 |
Dennd6a | E330009J07Rik | ENSMUSP00000039361 | ENSMUSP00000045103 | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity). | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | 0.660 |
Dennd6a | Fam45a | ENSMUSP00000039361 | ENSMUSP00000025957 | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity). | DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP- bound form. | 0.682 |
Dennd6b | Avl9 | ENSMUSP00000077978 | ENSMUSP00000031805 | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35 (By similarity); Belongs to the DENND6 family. | Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. | 0.572 |
Dennd6b | E330009J07Rik | ENSMUSP00000077978 | ENSMUSP00000045103 | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35 (By similarity); Belongs to the DENND6 family. | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | 0.566 |
Dennd6b | Fam45a | ENSMUSP00000077978 | ENSMUSP00000025957 | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35 (By similarity); Belongs to the DENND6 family. | DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP- bound form. | 0.608 |
E330009J07Rik | Avl9 | ENSMUSP00000045103 | ENSMUSP00000031805 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | Late secretory pathway protein AVL9 homolog; Functions in cell migration; Belongs to the AVL9 family. | 0.665 |
E330009J07Rik | Dennd6a | ENSMUSP00000045103 | ENSMUSP00000039361 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | Protein DENND6A; Guanine nucleotide exchange factor (GEF) for RAB14. Component of an endocytic recycling pathway that is required for the control of ADAM10 transport, shedding of N-cadherin/CDH2 by ADAM9 or ADAM10 and regulation of cell-cell junctions. Required for RAB14 recruitment to recycling endosomes (By similarity). | 0.660 |
E330009J07Rik | Dennd6b | ENSMUSP00000045103 | ENSMUSP00000077978 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | Protein DENND6B; Guanine nucleotide exchange factor (GEF) for RAB14. Also has some, lesser GEF activity towards RAB35 (By similarity); Belongs to the DENND6 family. | 0.566 |
E330009J07Rik | Fam45a | ENSMUSP00000045103 | ENSMUSP00000025957 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | DENN domain-containing protein 10; Guanine nucleotide exchange factor (GEF) regulating homeostasis of late endocytic pathway, including endosomal positioning, maturation and secretion, possibly through activating Rab proteins such as RAB27A and RAB27B. Seems to promote the exchange of GDP to GTP, converting inactive GDP-bound RAB27A and RAB27B into their active GTP- bound form. | 0.694 |
E330009J07Rik | Nudt22 | ENSMUSP00000045103 | ENSMUSP00000137738 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | Uridine diphosphate glucose pyrophosphatase NUDT22; Hydrolyzes UDP-glucose to glucose 1-phosphate and UMP and UDP-galactose to galactose 1-phosphate and UMP. Preferred substrate is UDP-glucose. | 0.529 |
E330009J07Rik | Ric1 | ENSMUSP00000045103 | ENSMUSP00000043437 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | RAB6A-GEF complex partner protein 1; The RIC1-RGP1 complex acts as a guanine nucleotide exchange factor (GEF), which activates RAB6A by exchanging bound GDP for free GTP and may thereby required for efficient fusion of endosome-derived vesicles with the Golgi compartment. The RIC1-RGP1 complex participates in the recycling of mannose-6-phosphate receptors. Required for phosphorylation and localization of GJA1. | 0.640 |
E330009J07Rik | Vamp1 | ENSMUSP00000045103 | ENSMUSP00000032487 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | Vesicle-associated membrane protein 1; Involved in the targeting and/or fusion of transport vesicles to their target membrane; Belongs to the synaptobrevin family. | 0.576 |
E330009J07Rik | Vamp4 | ENSMUSP00000045103 | ENSMUSP00000121977 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | Vesicle-associated membrane protein 4; Involved in the pathway that functions to remove an inhibitor (probably synaptotagmin-4) of calcium-triggered exocytosis during the maturation of secretory granules. May be a marker for this sorting pathway that is critical for remodeling the secretory response of granule (By similarity); Belongs to the synaptobrevin family. | 0.554 |
E330009J07Rik | Vamp5 | ENSMUSP00000045103 | ENSMUSP00000098843 | DENN domain-containing protein 11; Probable guanine nucleotide exchange factor (GEF). May promote the exchange of GDP to GTP, converting inactive GDP-bound small GTPases into their active GTP-bound form (Probable). May play a role in neuritogenesis, as well as in neuronal recovery and/or restructuring in the hippocampus following transient cerebral ischemia (By similarity). Belongs to the DENND11 family. | Vesicle-associated membrane protein 5; May participate in trafficking events that are associated with myogenesis, such as myoblast fusion and/or GLUT4 trafficking; Belongs to the synaptobrevin family. | 0.549 |