node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Ccdc18 | Limd2 | ENSMUSP00000036507 | ENSMUSP00000045357 | Coiled-coil domain-containing protein 18. | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.401 |
Ctag2l2 | Limd2 | ENSMUSP00000109752 | ENSMUSP00000045357 | CTAG2-like 2. | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.491 |
Fhl2 | Limd2 | ENSMUSP00000008280 | ENSMUSP00000045357 | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.437 |
Limd2 | Ccdc18 | ENSMUSP00000045357 | ENSMUSP00000036507 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Coiled-coil domain-containing protein 18. | 0.401 |
Limd2 | Ctag2l2 | ENSMUSP00000045357 | ENSMUSP00000109752 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | CTAG2-like 2. | 0.491 |
Limd2 | Fhl2 | ENSMUSP00000045357 | ENSMUSP00000008280 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Four and a half LIM domains protein 2; May function as a molecular transmitter linking various signaling pathways to transcriptional regulation. Negatively regulates the transcriptional repressor E4F1 and may function in cell growth. Inhibits the transcriptional activity of FOXO1 and its apoptotic function by enhancing the interaction of FOXO1 with SIRT1 and FOXO1 deacetylation (By similarity). Negatively regulates the calcineurin/NFAT signaling pathway in cardiomyocytes. | 0.437 |
Limd2 | Med14 | ENSMUSP00000045357 | ENSMUSP00000094239 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | 0.562 |
Limd2 | Midn | ENSMUSP00000045357 | ENSMUSP00000046967 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (By similarity). | 0.403 |
Limd2 | Mpp7 | ENSMUSP00000045357 | ENSMUSP00000111535 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity); Belongs to the MAGUK family. | 0.405 |
Limd2 | Pdlim2 | ENSMUSP00000045357 | ENSMUSP00000116200 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). | 0.692 |
Limd2 | Tmem160 | ENSMUSP00000045357 | ENSMUSP00000019302 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Transmembrane protein 160. | 0.431 |
Limd2 | Zfp771 | ENSMUSP00000045357 | ENSMUSP00000056959 | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | Zinc finger protein 771; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.526 |
Med14 | Limd2 | ENSMUSP00000094239 | ENSMUSP00000045357 | Mediator of RNA polymerase II transcription subunit 14; Component of the Mediator complex, a coactivator involved in the regulated transcription of nearly all RNA polymerase II-dependent genes. Mediator functions as a bridge to convey information from gene- specific regulatory proteins to the basal RNA polymerase II transcription machinery. Mediator is recruited to promoters by direct interactions with regulatory proteins and serves as a scaffold for the assembly of a functional preinitiation complex with RNA polymerase II and the general transcription factors (By similarity). | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.562 |
Midn | Limd2 | ENSMUSP00000046967 | ENSMUSP00000045357 | Midnolin; Facilitates ubiquitin-independent proteasomal degradation of polycomb protein CBX4. Plays a role in inhibiting the activity of glucokinase GCK and both glucose-induced and basal insulin secretion (By similarity). | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.403 |
Mpp7 | Limd2 | ENSMUSP00000111535 | ENSMUSP00000045357 | MAGUK p55 subfamily member 7; Acts as an important adapter that promotes epithelial cell polarity and tight junction formation via its interaction with DLG1. Involved in the assembly of protein complexes at sites of cell-cell contact (By similarity); Belongs to the MAGUK family. | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.405 |
Pdlim2 | Limd2 | ENSMUSP00000116200 | ENSMUSP00000045357 | PDZ and LIM domain protein 2; Probable adapter protein located at the actin cytoskeleton that promotes cell attachment. Necessary for the migratory capacity of epithelial cells. Overexpression enhances cell adhesion to collagen and fibronectin and suppresses anchorage independent growth. May contribute to tumor cell migratory capacity (By similarity). | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.692 |
Tmem160 | Limd2 | ENSMUSP00000019302 | ENSMUSP00000045357 | Transmembrane protein 160. | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.431 |
Zfp771 | Limd2 | ENSMUSP00000056959 | ENSMUSP00000045357 | Zinc finger protein 771; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | LIM domain-containing protein 2; Acts as an activator of the protein-kinase ILK, thereby regulating cell motility. | 0.526 |