node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Adgb | Alad | ENSMUSP00000045452 | ENSMUSP00000103068 | Androglobin; Belongs to the peptidase C2 family. | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | 0.556 |
Adgb | Cygb | ENSMUSP00000045452 | ENSMUSP00000021166 | Androglobin; Belongs to the peptidase C2 family. | Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer; Belongs to the globin family. | 0.827 |
Adgb | Iqca | ENSMUSP00000045452 | ENSMUSP00000108717 | Androglobin; Belongs to the peptidase C2 family. | Dynein regulatory complex protein 11; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the AAA ATPase family. DRC11 subfamily. | 0.558 |
Adgb | Lrguk | ENSMUSP00000045452 | ENSMUSP00000065146 | Androglobin; Belongs to the peptidase C2 family. | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | 0.547 |
Adgb | Mb | ENSMUSP00000045452 | ENSMUSP00000125995 | Androglobin; Belongs to the peptidase C2 family. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | 0.755 |
Adgb | Meig1 | ENSMUSP00000045452 | ENSMUSP00000070310 | Androglobin; Belongs to the peptidase C2 family. | Meiosis-expressed gene 1 protein; Essential for spermiogenesis; Belongs to the MEIG1 family. | 0.538 |
Adgb | Ngb | ENSMUSP00000045452 | ENSMUSP00000105806 | Androglobin; Belongs to the peptidase C2 family. | Neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti- apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. | 0.859 |
Adgb | Samd5 | ENSMUSP00000045452 | ENSMUSP00000097648 | Androglobin; Belongs to the peptidase C2 family. | Sterile alpha motif domain-containing protein 5. | 0.636 |
Adgb | Urod | ENSMUSP00000045452 | ENSMUSP00000030446 | Androglobin; Belongs to the peptidase C2 family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.536 |
Adgb | Uros | ENSMUSP00000045452 | ENSMUSP00000033276 | Androglobin; Belongs to the peptidase C2 family. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity). Belongs to the uroporphyrinogen-III synthase family. | 0.551 |
Alad | Adgb | ENSMUSP00000103068 | ENSMUSP00000045452 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Androglobin; Belongs to the peptidase C2 family. | 0.556 |
Alad | Urod | ENSMUSP00000103068 | ENSMUSP00000030446 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Uroporphyrinogen decarboxylase; Catalyzes the decarboxylation of four acetate groups of uroporphyrinogen-III to yield coproporphyrinogen-III. | 0.947 |
Alad | Uros | ENSMUSP00000103068 | ENSMUSP00000033276 | Delta-aminolevulinic acid dehydratase; Catalyzes an early step in the biosynthesis of tetrapyrroles. Binds two molecules of 5-aminolevulinate per subunit, each at a distinct site, and catalyzes their condensation to form porphobilinogen (By similarity); Belongs to the ALAD family. | Uroporphyrinogen-III synthase; Catalyzes cyclization of the linear tetrapyrrole, hydroxymethylbilane, to the macrocyclic uroporphyrinogen III, the branch point for the various sub-pathways leading to the wide diversity of porphyrins. Porphyrins act as cofactors for a multitude of enzymes that perform a variety of processes within the cell such as methionine synthesis (vitamin B12) or oxygen transport (heme) (By similarity). Belongs to the uroporphyrinogen-III synthase family. | 0.984 |
Cygb | Adgb | ENSMUSP00000021166 | ENSMUSP00000045452 | Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer; Belongs to the globin family. | Androglobin; Belongs to the peptidase C2 family. | 0.827 |
Cygb | Mb | ENSMUSP00000021166 | ENSMUSP00000125995 | Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer; Belongs to the globin family. | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | 0.530 |
Cygb | Ngb | ENSMUSP00000021166 | ENSMUSP00000105806 | Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer; Belongs to the globin family. | Neuroglobin; Involved in oxygen transport in the brain. Hexacoordinate globin, displaying competitive binding of oxygen or the distal His residue to the iron atom. Not capable of penetrating cell membranes. The deoxygenated form exhibits nitrite reductase activity inhibiting cellular respiration via NO-binding to cytochrome c oxidase. Involved in neuroprotection during oxidative stress. May exert its anti- apoptotic activity by acting to reset the trigger level of mitochondrial cytochrome c release necessary to commit the cells to apoptosis. | 0.948 |
Iqca | Adgb | ENSMUSP00000108717 | ENSMUSP00000045452 | Dynein regulatory complex protein 11; Component of the nexin-dynein regulatory complex (N-DRC), a key regulator of ciliary/flagellar motility which maintains the alignment and integrity of the distal axoneme and regulates microtubule sliding in motile axonemes; Belongs to the AAA ATPase family. DRC11 subfamily. | Androglobin; Belongs to the peptidase C2 family. | 0.558 |
Lrguk | Adgb | ENSMUSP00000065146 | ENSMUSP00000045452 | Leucine-rich repeat and guanylate kinase domain-containing protein; Involved in multiple aspects of sperm assembly including acrosome attachment, shaping of the sperm head and in the early aspects of axoneme development. Not essential for primary cilium biogenesis. | Androglobin; Belongs to the peptidase C2 family. | 0.547 |
Mb | Adgb | ENSMUSP00000125995 | ENSMUSP00000045452 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | Androglobin; Belongs to the peptidase C2 family. | 0.755 |
Mb | Cygb | ENSMUSP00000125995 | ENSMUSP00000021166 | Myoglobin; Serves as a reserve supply of oxygen and facilitates the movement of oxygen within muscles. | Cytoglobin; May have a protective function during conditions of oxidative stress. May be involved in intracellular oxygen storage or transfer; Belongs to the globin family. | 0.530 |