Export your current network:
... as a vector graphic:
SVG: scalable vector graphic - can be opened and edited in Illustrator, CorelDraw, Dia, etc
... as short tabular text output:
TSV: tab separated values - can be opened in Excel and Cytoscape (lists only one-way edges: A-B)
... as tabular text output:
TSV: tab separated values - can be opened in Excel (lists reciprocal edges: A-B,B-A)
... as an XML summary:
structured XML interaction data, according to the 'PSI-MI' data standard
... protein node degrees:
node degree of proteins in your network (given the current score cut-off)
... network coordinates:
a flat-file format describing the coordinates and colors of nodes in the network
... protein sequences:
MFA: multi-fasta format - containing the aminoacid sequences in the network
... protein annotations:
a tab-delimited file describing the names, domains and descriptions of proteins in your network
... functional annotations:
a tab-delimited file containing all known functional terms of protiens in your network
Browse interactions in tabular form:
| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| Atp13a1 | Gmip | ENSMUSP00000034326 | ENSMUSP00000045676 | Manganese-transporting p-type atpase; Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity) | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | 0.629 |
| Atp13a1 | Yjefn3 | ENSMUSP00000034326 | ENSMUSP00000118931 | Manganese-transporting p-type atpase; Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity) | YjeF N-terminal domain-containing protein 3; May play a role in spermiogenesis and oogenesis | 0.698 |
| Cdc42 | Gmip | ENSMUSP00000054634 | ENSMUSP00000045676 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). R [...] | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | 0.795 |
| Cdc42 | Inppl1 | ENSMUSP00000054634 | ENSMUSP00000048057 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). R [...] | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Ak [...] | 0.428 |
| Cdc42 | Rac2 | ENSMUSP00000054634 | ENSMUSP00000036384 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). R [...] | Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | 0.604 |
| Cdc42 | Rem2 | ENSMUSP00000054634 | ENSMUSP00000127199 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). R [...] | Rad and gem related gtp binding protein 2; Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis | 0.410 |
| Cdc42 | Rhoa | ENSMUSP00000054634 | ENSMUSP00000007959 | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). R [...] | Ras homolog gene family, member a; Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1- [...] | 0.971 |
| Dgkh | Drd3 | ENSMUSP00000074290 | ENSMUSP00000023390 | Diacylglycerol kinase (atp); Diacylglycerol kinase, eta | D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity) | 0.531 |
| Dgkh | Gmip | ENSMUSP00000074290 | ENSMUSP00000045676 | Diacylglycerol kinase (atp); Diacylglycerol kinase, eta | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | 0.614 |
| Drd3 | Dgkh | ENSMUSP00000023390 | ENSMUSP00000074290 | D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity) | Diacylglycerol kinase (atp); Diacylglycerol kinase, eta | 0.531 |
| Drd3 | Gmip | ENSMUSP00000023390 | ENSMUSP00000045676 | D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity) | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | 0.572 |
| Gmip | Atp13a1 | ENSMUSP00000045676 | ENSMUSP00000034326 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | Manganese-transporting p-type atpase; Manganese-transporting ATPase 13A1; Mediates manganese transport into the endoplasmic reticulum. The ATPase activity is required for cellular manganese homeostasis (By similarity) | 0.629 |
| Gmip | Cdc42 | ENSMUSP00000045676 | ENSMUSP00000054634 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | Cell division control protein 42 homolog; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and an inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses. Involved in epithelial cell polarization processes. Regulates the bipolar attachment of spindle microtubules to kinetochores before chromosome congression in metaphase. Plays a role in the extension and maintenance of the formation of thin, actin-rich surface projections called filopodia. Mediates CDC42-dependent cell migration (By similarity). R [...] | 0.795 |
| Gmip | Dgkh | ENSMUSP00000045676 | ENSMUSP00000074290 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | Diacylglycerol kinase (atp); Diacylglycerol kinase, eta | 0.614 |
| Gmip | Drd3 | ENSMUSP00000045676 | ENSMUSP00000023390 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | D(3) dopamine receptor; Dopamine receptor whose activity is mediated by G proteins which inhibit adenylyl cyclase. Promotes cell proliferation (By similarity) | 0.572 |
| Gmip | Gnptg | ENSMUSP00000045676 | ENSMUSP00000110807 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | N-acetylglucosamine-1-phosphate transferase, gamma subunit; N-acetylglucosamine-1-phosphotransferase subunit gamma; Non-catalytic subunit of the N-acetylglucosamine-1- phosphotransferase complex, an enzyme that catalyzes the formation of mannose 6-phosphate (M6P) markers on high mannose type oligosaccharides in the Golgi apparatus. Binds and presents the high mannose glycans of the acceptor to the catalytic alpha and beta subunits (GNPTAB). Enhances the rate of N-acetylglucosamine- 1-phosphate transfer to the oligosaccharides of acid hydrolase acceptors | 0.671 |
| Gmip | Inppl1 | ENSMUSP00000045676 | ENSMUSP00000048057 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | Phosphatidylinositol-3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol 3,4,5-trisphosphate 5-phosphatase 2; Phosphatidylinositol (PtdIns) phosphatase that specifically hydrolyzes the 5-phosphate of phosphatidylinositol- 3,4,5-trisphosphate (PtdIns(3,4,5)P3) to produce PtdIns(3,4)P2, thereby negatively regulating the PI3K (phosphoinositide 3-kinase) pathways. Plays a central role in regulation of PI3K-dependent insulin signaling, although the precise molecular mechanisms and signaling pathways remain unclear. While overexpression reduces both insulin-stimulated MAP kinase and Ak [...] | 0.685 |
| Gmip | Rac2 | ENSMUSP00000045676 | ENSMUSP00000036384 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | Ras-related C3 botulinum toxin substrate 2; Plasma membrane-associated small GTPase which cycles between an active GTP-bound and inactive GDP-bound state. In active state binds to a variety of effector proteins to regulate cellular responses, such as secretory processes, phagocytose of apoptotic cells and epithelial cell polarization. Augments the production of reactive oxygen species (ROS) by NADPH oxidase | 0.583 |
| Gmip | Rem2 | ENSMUSP00000045676 | ENSMUSP00000127199 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | Rad and gem related gtp binding protein 2; Binds GTP saturably and exhibits a low intrinsic rate of GTP hydrolysis | 0.622 |
| Gmip | Rhoa | ENSMUSP00000045676 | ENSMUSP00000007959 | GEM-interacting protein; Stimulates, in vitro and in vivo, the GTPase activity of RhoA | Ras homolog gene family, member a; Transforming protein RhoA; Regulates a signal transduction pathway linking plasma membrane receptors to the assembly of focal adhesions and actin stress fibers. Involved in a microtubule-dependent signal that is required for the myosin contractile ring formation during cell cycle cytokinesis. Plays an essential role in cleavage furrow formation. May be an activator of PLCE1. Activated by ARHGEF2, which promotes the exchange of GDP for GTP. Essential for the SPATA13-mediated regulation of cell migration and adhesion assembly and disassembly. The MEMO1- [...] | 0.576 |
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