node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Cdc42ep5 | Lair1 | ENSMUSP00000092508 | ENSMUSP00000083589 | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. | Leukocyte-associated immunoglobulin-like receptor 1; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T- cells, down-regulating IL2 and IFNG production while induc [...] | 0.591 |
Cdc42ep5 | Leng8 | ENSMUSP00000092508 | ENSMUSP00000046465 | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. | Leukocyte receptor cluster member 8 homolog. | 0.761 |
Cdc42ep5 | Leng9 | ENSMUSP00000092508 | ENSMUSP00000061079 | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. | Leukocyte receptor cluster member 9. | 0.638 |
Cdc42ep5 | Ttyh1 | ENSMUSP00000092508 | ENSMUSP00000078384 | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family. | 0.676 |
Fnbp4 | Leng8 | ENSMUSP00000013759 | ENSMUSP00000046465 | Formin-binding protein 4. | Leukocyte receptor cluster member 8 homolog. | 0.585 |
Gigyf1 | Leng8 | ENSMUSP00000031727 | ENSMUSP00000046465 | GRB10-interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1. | Leukocyte receptor cluster member 8 homolog. | 0.548 |
Ilvbl | Leng8 | ENSMUSP00000101023 | ENSMUSP00000046465 | Acetolactate synthase-like protein; Belongs to the TPP enzyme family. | Leukocyte receptor cluster member 8 homolog. | 0.651 |
Lair1 | Cdc42ep5 | ENSMUSP00000083589 | ENSMUSP00000092508 | Leukocyte-associated immunoglobulin-like receptor 1; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T- cells, down-regulating IL2 and IFNG production while induc [...] | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. | 0.591 |
Lair1 | Leng8 | ENSMUSP00000083589 | ENSMUSP00000046465 | Leukocyte-associated immunoglobulin-like receptor 1; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T- cells, down-regulating IL2 and IFNG production while induc [...] | Leukocyte receptor cluster member 8 homolog. | 0.596 |
Lair1 | Ttyh1 | ENSMUSP00000083589 | ENSMUSP00000078384 | Leukocyte-associated immunoglobulin-like receptor 1; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T- cells, down-regulating IL2 and IFNG production while induc [...] | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family. | 0.473 |
Leng8 | Cdc42ep5 | ENSMUSP00000046465 | ENSMUSP00000092508 | Leukocyte receptor cluster member 8 homolog. | Cdc42 effector protein 5; Probably involved in the organization of the actin cytoskeleton. May act downstream of CDC42 to induce actin filament assembly leading to cell shape changes. Induces pseudopodia formation in fibroblasts. Inhibits MAPK8 independently of CDC42 binding. Controls septin organization and this effect is negatively regulated by CDC42. | 0.761 |
Leng8 | Fnbp4 | ENSMUSP00000046465 | ENSMUSP00000013759 | Leukocyte receptor cluster member 8 homolog. | Formin-binding protein 4. | 0.585 |
Leng8 | Gigyf1 | ENSMUSP00000046465 | ENSMUSP00000031727 | Leukocyte receptor cluster member 8 homolog. | GRB10-interacting GYF protein 1; May act cooperatively with GRB10 to regulate tyrosine kinase receptor signaling. May increase IGF1 receptor phosphorylation under IGF1 stimulation as well as phosphorylation of IRS1 and SHC1. | 0.548 |
Leng8 | Ilvbl | ENSMUSP00000046465 | ENSMUSP00000101023 | Leukocyte receptor cluster member 8 homolog. | Acetolactate synthase-like protein; Belongs to the TPP enzyme family. | 0.651 |
Leng8 | Lair1 | ENSMUSP00000046465 | ENSMUSP00000083589 | Leukocyte receptor cluster member 8 homolog. | Leukocyte-associated immunoglobulin-like receptor 1; Functions as an inhibitory receptor that plays a constitutive negative regulatory role on cytolytic function of natural killer (NK) cells, B-cells and T-cells. Activation by Tyr phosphorylation results in recruitment and activation of the phosphatases PTPN6 and PTPN11. It also reduces the increase of intracellular calcium evoked by B-cell receptor ligation. May also play its inhibitory role independently of SH2-containing phosphatases. Modulates cytokine production in CD4+ T- cells, down-regulating IL2 and IFNG production while induc [...] | 0.596 |
Leng8 | Leng9 | ENSMUSP00000046465 | ENSMUSP00000061079 | Leukocyte receptor cluster member 8 homolog. | Leukocyte receptor cluster member 9. | 0.663 |
Leng8 | Pcid2 | ENSMUSP00000046465 | ENSMUSP00000133204 | Leukocyte receptor cluster member 8 homolog. | PCI domain-containing protein 2; Required for B-cell survival through the regulation of the expression of cell-cycle checkpoint MAD2L1 protein during B cell differentiation. As a component of the TREX-2 complex, involved in the export of mRNAs to the cytoplasm through the nuclear pores (By similarity). Binds and stabilizes BRCA2 and is thus involved in the control of R-loop-associated DNA damage and transcription-associated genomic instability. R-loop accumulation does not increase in PCID2-depleted cells (By similarity). | 0.920 |
Leng8 | Rpl37 | ENSMUSP00000046465 | ENSMUSP00000046506 | Leukocyte receptor cluster member 8 homolog. | 60S ribosomal protein L37; Binds to the 23S rRNA; Belongs to the eukaryotic ribosomal protein eL37 family. | 0.524 |
Leng8 | Sem1 | ENSMUSP00000046465 | ENSMUSP00000040741 | Leukocyte receptor cluster member 8 homolog. | 26S proteasome complex subunit SEM1; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. Component of the TREX-2 complex (transcription and export complex 2), com [...] | 0.823 |
Leng8 | Ttyh1 | ENSMUSP00000046465 | ENSMUSP00000078384 | Leukocyte receptor cluster member 8 homolog. | Protein tweety homolog 1; Probable chloride channel. May be involved in cell adhesion (By similarity); Belongs to the tweety family. | 0.688 |