node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Arid2 | Elf1 | ENSMUSP00000093969 | ENSMUSP00000046515 | AT-rich interactive domain-containing protein 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Belongs to the RFX family. | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | 0.404 |
Arid2 | Zfp821 | ENSMUSP00000093969 | ENSMUSP00000034163 | AT-rich interactive domain-containing protein 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Belongs to the RFX family. | Zinc finger protein 821; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.452 |
Cbfb | Elf1 | ENSMUSP00000059382 | ENSMUSP00000046515 | Core-binding factor subunit beta; Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine l [...] | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | 0.530 |
Cbfb | Runx1 | ENSMUSP00000059382 | ENSMUSP00000023673 | Core-binding factor subunit beta; Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine l [...] | Runt-related transcription factor 1; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T [...] | 0.999 |
Cd1d1 | Elf1 | ENSMUSP00000029717 | ENSMUSP00000046515 | Antigen-presenting glycoprotein CD1d1; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | 0.425 |
Elf1 | Arid2 | ENSMUSP00000046515 | ENSMUSP00000093969 | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | AT-rich interactive domain-containing protein 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Belongs to the RFX family. | 0.404 |
Elf1 | Cbfb | ENSMUSP00000046515 | ENSMUSP00000059382 | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | Core-binding factor subunit beta; Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine l [...] | 0.530 |
Elf1 | Cd1d1 | ENSMUSP00000046515 | ENSMUSP00000029717 | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | Antigen-presenting glycoprotein CD1d1; Antigen-presenting protein that binds self and non-self glycolipids and presents them to T-cell receptors on natural killer T- cells. | 0.425 |
Elf1 | Ephb4 | ENSMUSP00000046515 | ENSMUSP00000106684 | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | Ephrin type-B receptor 4; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and bl [...] | 0.481 |
Elf1 | Kdm2a | ENSMUSP00000046515 | ENSMUSP00000047683 | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the c [...] | 0.406 |
Elf1 | Runx1 | ENSMUSP00000046515 | ENSMUSP00000023673 | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | Runt-related transcription factor 1; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T [...] | 0.576 |
Elf1 | Zfp821 | ENSMUSP00000046515 | ENSMUSP00000034163 | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | Zinc finger protein 821; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | 0.484 |
Ephb4 | Elf1 | ENSMUSP00000106684 | ENSMUSP00000046515 | Ephrin type-B receptor 4; Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 it is involved in the regulation of cell adhesion and migration, and plays a central role in heart morphogenesis, angiogenesis and bl [...] | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | 0.481 |
Kdm2a | Elf1 | ENSMUSP00000047683 | ENSMUSP00000046515 | Lysine-specific demethylase 2A; Histone demethylase that specifically demethylates 'Lys-36' of histone H3, thereby playing a central role in histone code. Preferentially demethylates dimethylated H3 'Lys-36' residue while it has weak or no activity for mono- and tri-methylated H3 'Lys-36'. May also recognize and bind to some phosphorylated proteins and promote their ubiquitination and degradation. Required to maintain the heterochromatic state. Associates with centromeres and represses transcription of small non-coding RNAs that are encoded by the clusters of satellite repeats at the c [...] | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | 0.406 |
Runx1 | Cbfb | ENSMUSP00000023673 | ENSMUSP00000059382 | Runt-related transcription factor 1; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T [...] | Core-binding factor subunit beta; Forms the heterodimeric complex core-binding factor (CBF) with RUNX family proteins (RUNX1, RUNX2, and RUNX3). RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'-TGTGGT-3', or very rarely, 5'- TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine l [...] | 0.999 |
Runx1 | Elf1 | ENSMUSP00000023673 | ENSMUSP00000046515 | Runt-related transcription factor 1; Forms the heterodimeric complex core-binding factor (CBF) with CBFB. RUNX members modulate the transcription of their target genes through recognizing the core consensus binding sequence 5'- TGTGGT-3', or very rarely, 5'-TGCGGT-3', within their regulatory regions via their runt domain, while CBFB is a non-DNA-binding regulatory subunit that allosterically enhances the sequence-specific DNA-binding capacity of RUNX. The heterodimers bind to the core site of a number of enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T [...] | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | 0.576 |
Zfp821 | Arid2 | ENSMUSP00000034163 | ENSMUSP00000093969 | Zinc finger protein 821; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | AT-rich interactive domain-containing protein 2; Involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). Required for the stability of the SWI/SNF chromatin remodeling complex SWI/SNF-B (PBAF). May be involved in targeting the complex to different genes. May be involved in regulating transcriptional activation of cardiac genes. Belongs to the RFX family. | 0.452 |
Zfp821 | Elf1 | ENSMUSP00000034163 | ENSMUSP00000046515 | Zinc finger protein 821; May be involved in transcriptional regulation; Belongs to the krueppel C2H2-type zinc-finger protein family. | ETS-related transcription factor Elf-1; Transcription factor that activates the LYN and BLK promoters; Belongs to the ETS family. | 0.484 |