node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
1700057G04Rik | Ano5 | ENSMUSP00000096077 | ENSMUSP00000046884 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.511 |
1700057G04Rik | Clca3a1 | ENSMUSP00000096077 | ENSMUSP00000054526 | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. | Calcium-activated chloride channel regulator 3A-1; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner. | 0.440 |
Ano5 | 1700057G04Rik | ENSMUSP00000046884 | ENSMUSP00000096077 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. | 0.511 |
Ano5 | Capn3 | ENSMUSP00000046884 | ENSMUSP00000028749 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.599 |
Ano5 | Cav3 | ENSMUSP00000046884 | ENSMUSP00000074922 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity); Belongs to the caveolin family. | 0.521 |
Ano5 | Ccdc58 | ENSMUSP00000046884 | ENSMUSP00000125874 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Coiled-coil domain-containing protein 58; Belongs to the CCDC58 family. | 0.514 |
Ano5 | Clca3a1 | ENSMUSP00000046884 | ENSMUSP00000054526 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Calcium-activated chloride channel regulator 3A-1; Plays a role in modulating chloride current across the plasma membrane in a calcium-dependent manner. | 0.519 |
Ano5 | Dysf | ENSMUSP00000046884 | ENSMUSP00000080579 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Belongs to the ferlin family. | 0.786 |
Ano5 | Fkrp | ENSMUSP00000046884 | ENSMUSP00000059091 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Fukutin-related protein; Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1) (By similarity). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta- 1 (By similarity). | 0.655 |
Ano5 | Plscr5 | ENSMUSP00000046884 | ENSMUSP00000136181 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Phospholipid scramblase; May mediate accelerated ATP-independent bidirectional transbilayer migration of phospholipids upon binding calcium ions that results in a loss of phospholipid asymmetry in the plasma membrane. Belongs to the phospholipid scramblase family. | 0.521 |
Ano5 | Sgca | ENSMUSP00000046884 | ENSMUSP00000099451 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Alpha-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.600 |
Ano5 | Sgcg | ENSMUSP00000046884 | ENSMUSP00000077106 | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | Gamma-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.563 |
Capn3 | Ano5 | ENSMUSP00000028749 | ENSMUSP00000046884 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.599 |
Capn3 | Cav3 | ENSMUSP00000028749 | ENSMUSP00000074922 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity); Belongs to the caveolin family. | 0.775 |
Capn3 | Dysf | ENSMUSP00000028749 | ENSMUSP00000080579 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Dysferlin; Key calcium ion sensor involved in the Ca(2+)-triggered synaptic vesicle-plasma membrane fusion. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Belongs to the ferlin family. | 0.932 |
Capn3 | Fkrp | ENSMUSP00000028749 | ENSMUSP00000059091 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Fukutin-related protein; Catalyzes the transfer of CDP-ribitol to ribitol 5-phosphate previously attached by FKTN/fukutin of to the phosphorylated O-mannosyl trisaccharide (N-acetylgalactosamine-beta-3-N-acetylglucosamine-beta-4- (phosphate-6-)mannose), a carbohydrate structure present in alpha- dystroglycan (DAG1) (By similarity). This constitutes the second step in the formation of the ribose 5-phosphate tandem repeat which links the phosphorylated O-mannosyl trisaccharide to the ligand binding moiety composed of repeats of 3-xylosyl-alpha-1,3-glucuronic acid-beta- 1 (By similarity). | 0.707 |
Capn3 | Sgca | ENSMUSP00000028749 | ENSMUSP00000099451 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Alpha-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.704 |
Capn3 | Sgcg | ENSMUSP00000028749 | ENSMUSP00000077106 | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | Gamma-sarcoglycan; Component of the sarcoglycan complex, a subcomplex of the dystrophin-glycoprotein complex which forms a link between the F-actin cytoskeleton and the extracellular matrix. | 0.687 |
Cav3 | Ano5 | ENSMUSP00000074922 | ENSMUSP00000046884 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity); Belongs to the caveolin family. | Anoctamin-5; Does not exhibit calcium-activated chloride channel (CaCC) activity. | 0.521 |
Cav3 | Capn3 | ENSMUSP00000074922 | ENSMUSP00000028749 | Caveolin-3; May act as a scaffolding protein within caveolar membranes. Interacts directly with G-protein alpha subunits and can functionally regulate their activity. May also regulate voltage-gated potassium channels. Plays a role in the sarcolemma repair mechanism of both skeletal muscle and cardiomyocytes that permits rapid resealing of membranes disrupted by mechanical stress. Mediates the recruitment of CAVIN2 and CAVIN3 proteins to the caveolae (By similarity); Belongs to the caveolin family. | Calpain-3; Calcium-regulated non-lysosomal thiol-protease; Belongs to the peptidase C2 family. | 0.775 |