node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atrx | Dap | ENSMUSP00000109203 | ENSMUSP00000047186 | Transcriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). | 0.514 |
Atrx | Daxx | ENSMUSP00000109203 | ENSMUSP00000128504 | Transcriptional regulator ATRX; Involved in transcriptional regulation and chromatin remodeling. Facilitates DNA replication in multiple cellular environments and is required for efficient replication of a subset of genomic loci. Binds to DNA tandem repeat sequences in both telomeres and euchromatin and in vitro binds DNA quadruplex structures. May help stabilizing G-rich regions into regular chromatin structures by remodeling G4 DNA and incorporating H3.3-containing nucleosomes. Catalytic component of the chromatin remodeling complex ATRX:DAXX which has ATP-dependent DNA translocase a [...] | Death domain-associated protein 6; Transcription corepressor known to repress transcriptional potential of several sumoylated transcription factors. Down-regulates basal and activated transcription. Its transcription repressor activity is modulated by recruiting it to subnuclear compartments like the nucleolus or PML/POD/ND10 nuclear bodies through interactions with MCSR1 and PML, respectively. Seems to regulate transcription in PML/POD/ND10 nuclear bodies together with PML and may influence TNFRSF6-dependent apoptosis thereby. Inhibits transcriptional activation of PAX3 and ETS1 throu [...] | 0.999 |
Calm3 | Calm4 | ENSMUSP00000019514 | ENSMUSP00000041636 | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. | Calmodulin-4; Implicated in the early stage of ectopic ossification. | 0.993 |
Calm3 | Calm5 | ENSMUSP00000019514 | ENSMUSP00000139342 | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. | Skin calmodulin-related protein 2. | 0.993 |
Calm3 | Calml3 | ENSMUSP00000019514 | ENSMUSP00000076880 | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. | Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity). | 0.992 |
Calm3 | Calml4 | ENSMUSP00000019514 | ENSMUSP00000034777 | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. | Calmodulin-like protein 4. | 0.993 |
Calm3 | Dap | ENSMUSP00000019514 | ENSMUSP00000047186 | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). | 0.493 |
Calm3 | Dapk1 | ENSMUSP00000019514 | ENSMUSP00000076666 | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. | Death-associated protein kinase 1; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress [...] | 0.685 |
Calm4 | Calm3 | ENSMUSP00000041636 | ENSMUSP00000019514 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. | 0.993 |
Calm4 | Calm5 | ENSMUSP00000041636 | ENSMUSP00000139342 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Skin calmodulin-related protein 2. | 0.955 |
Calm4 | Calml3 | ENSMUSP00000041636 | ENSMUSP00000076880 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity). | 0.961 |
Calm4 | Calml4 | ENSMUSP00000041636 | ENSMUSP00000034777 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Calmodulin-like protein 4. | 0.953 |
Calm4 | Dap | ENSMUSP00000041636 | ENSMUSP00000047186 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). | 0.495 |
Calm4 | Dapk1 | ENSMUSP00000041636 | ENSMUSP00000076666 | Calmodulin-4; Implicated in the early stage of ectopic ossification. | Death-associated protein kinase 1; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress [...] | 0.684 |
Calm5 | Calm3 | ENSMUSP00000139342 | ENSMUSP00000019514 | Skin calmodulin-related protein 2. | Calmodulin-1; Calmodulin mediates the control of a large number of enzymes, ion channels, aquaporins and other proteins through calcium-binding. Among the enzymes to be stimulated by the calmodulin-calcium complex are a number of protein kinases and phosphatases. Together with CCP110 and centrin, is involved in a genetic pathway that regulates the centrosome cycle and progression through cytokinesis. Mediates calcium- dependent inactivation of CACNA1C. Positively regulates calcium- activated potassium channel activity of KCNN2. | 0.993 |
Calm5 | Calm4 | ENSMUSP00000139342 | ENSMUSP00000041636 | Skin calmodulin-related protein 2. | Calmodulin-4; Implicated in the early stage of ectopic ossification. | 0.955 |
Calm5 | Calml3 | ENSMUSP00000139342 | ENSMUSP00000076880 | Skin calmodulin-related protein 2. | Calmodulin-like protein 3; May function as a specific light chain of unconventional myosin-10 (MYO10), also enhances MYO10 translation, possibly by acting as a chaperone for the emerging MYO10 heavy chain protein. May compete with calmodulin by binding, with different affinities, to cellular substrates (By similarity). | 0.953 |
Calm5 | Calml4 | ENSMUSP00000139342 | ENSMUSP00000034777 | Skin calmodulin-related protein 2. | Calmodulin-like protein 4. | 0.965 |
Calm5 | Dap | ENSMUSP00000139342 | ENSMUSP00000047186 | Skin calmodulin-related protein 2. | Death-associated protein 1; Negative regulator of autophagy. Involved in mediating interferon-gamma-induced cell death (By similarity). | 0.495 |
Calm5 | Dapk1 | ENSMUSP00000139342 | ENSMUSP00000076666 | Skin calmodulin-related protein 2. | Death-associated protein kinase 1; Calcium/calmodulin-dependent serine/threonine kinase involved in multiple cellular signaling pathways that trigger cell survival, apoptosis, and autophagy. Regulates both type I apoptotic and type II autophagic cell deaths signal, depending on the cellular setting. The former is caspase-dependent, while the latter is caspase-independent and is characterized by the accumulation of autophagic vesicles. Phosphorylates PIN1 resulting in inhibition of its catalytic activity, nuclear localization, and cellular function. Phosphorylates TPM1, enhancing stress [...] | 0.683 |