node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
Atad2b | Bivm | ENSMUSP00000047445 | ENSMUSP00000110357 | ATPase family, AAA domain-containing 2B. | Basic immunoglobulin-like variable motif-containing protein. | 0.590 |
Atad2b | Brwd3 | ENSMUSP00000047445 | ENSMUSP00000123588 | ATPase family, AAA domain-containing 2B. | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). | 0.573 |
Atad2b | Btaf1 | ENSMUSP00000047445 | ENSMUSP00000097093 | ATPase family, AAA domain-containing 2B. | B-TFIID TATA-box-binding protein-associated factor 1. | 0.594 |
Atad2b | Cep350 | ENSMUSP00000047445 | ENSMUSP00000120085 | ATPase family, AAA domain-containing 2B. | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | 0.658 |
Atad2b | Gpd2 | ENSMUSP00000047445 | ENSMUSP00000130992 | ATPase family, AAA domain-containing 2B. | Glycerol-3-phosphate dehydrogenase, mitochondrial. | 0.611 |
Atad2b | Mysm1 | ENSMUSP00000047445 | ENSMUSP00000075269 | ATPase family, AAA domain-containing 2B. | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | 0.607 |
Atad2b | Psmd11 | ENSMUSP00000047445 | ENSMUSP00000017572 | ATPase family, AAA domain-containing 2B. | 26S proteasome non-ATPase regulatory subunit 11; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. In the complex, PSMD11 is required for proteasome assembly. P [...] | 0.553 |
Atad2b | Psmd4 | ENSMUSP00000047445 | ENSMUSP00000071589 | ATPase family, AAA domain-containing 2B. | 26S proteasome non-ATPase regulatory subunit 4; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair. PSMD4 acts as an ubiquitin receptor subunit through ubiquitin- [...] | 0.565 |
Atad2b | Psmd6 | ENSMUSP00000047445 | ENSMUSP00000022256 | ATPase family, AAA domain-containing 2B. | 26S proteasome non-ATPase regulatory subunit 6; Component of the 26S proteasome, a multiprotein complex involved in the ATP-dependent degradation of ubiquitinated proteins. This complex plays a key role in the maintenance of protein homeostasis by removing misfolded or damaged proteins, which could impair cellular functions, and by removing proteins whose functions are no longer required. Therefore, the proteasome participates in numerous cellular processes, including cell cycle progression, apoptosis, or DNA damage repair; Belongs to the proteasome subunit S10 family. | 0.577 |
Atad2b | Supt16 | ENSMUSP00000047445 | ENSMUSP00000042283 | ATPase family, AAA domain-containing 2B. | FACT complex subunit SPT16; Component of the FACT complex, a general chromatin factor that acts to reorganize nucleosomes. The FACT complex is involved in multiple processes that require DNA as a template such as mRNA elongation, DNA replication and DNA repair. During transcription elongation the FACT complex acts as a histone chaperone that both destabilizes and restores nucleosomal structure. It facilitates the passage of RNA polymerase II and transcription by promoting the dissociation of one histone H2A-H2B dimer from the nucleosome, then subsequently promotes the reestablishment o [...] | 0.674 |
Bivm | Atad2b | ENSMUSP00000110357 | ENSMUSP00000047445 | Basic immunoglobulin-like variable motif-containing protein. | ATPase family, AAA domain-containing 2B. | 0.590 |
Brwd3 | Atad2b | ENSMUSP00000123588 | ENSMUSP00000047445 | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). | ATPase family, AAA domain-containing 2B. | 0.573 |
Brwd3 | Mysm1 | ENSMUSP00000123588 | ENSMUSP00000075269 | Bromodomain and WD repeat-containing protein 3; Plays a role in the regulation of cell morphology and cytoskeletal organization. Required in the control of cell shape (By similarity). | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | 0.461 |
Btaf1 | Atad2b | ENSMUSP00000097093 | ENSMUSP00000047445 | B-TFIID TATA-box-binding protein-associated factor 1. | ATPase family, AAA domain-containing 2B. | 0.594 |
Btaf1 | Cep350 | ENSMUSP00000097093 | ENSMUSP00000120085 | B-TFIID TATA-box-binding protein-associated factor 1. | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | 0.419 |
Btaf1 | Mysm1 | ENSMUSP00000097093 | ENSMUSP00000075269 | B-TFIID TATA-box-binding protein-associated factor 1. | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | 0.491 |
Cep350 | Atad2b | ENSMUSP00000120085 | ENSMUSP00000047445 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | ATPase family, AAA domain-containing 2B. | 0.658 |
Cep350 | Btaf1 | ENSMUSP00000120085 | ENSMUSP00000097093 | Centrosome-associated protein 350; Plays an essential role in centriole growth by stabilizing a procentriolar seed composed of at least, SASS6 and CENPJ. Required for anchoring microtubules to the centrosomes and for the integrity of the microtubule network. Recruits PPARA to discrete subcellular compartments and thereby modulates PPARA activity. Required for ciliation. | B-TFIID TATA-box-binding protein-associated factor 1. | 0.419 |
Gpd2 | Atad2b | ENSMUSP00000130992 | ENSMUSP00000047445 | Glycerol-3-phosphate dehydrogenase, mitochondrial. | ATPase family, AAA domain-containing 2B. | 0.611 |
Mysm1 | Atad2b | ENSMUSP00000075269 | ENSMUSP00000047445 | Histone H2A deubiquitinase MYSM1; Metalloprotease that specifically deubiquitinates monoubiquitinated histone H2A, a specific tag for epigenetic transcriptional repression, thereby acting as a coactivator. Preferentially deubiquitinates monoubiquitinated H2A in hyperacetylated nucleosomes. Deubiquitination of histone H2A leads to facilitate the phosphorylation and dissociation of histone H1 from the nucleosome. Acts as a coactivator by participating in the initiation and elongation steps of androgen receptor (AR)-induced gene activation. Required for correct regulation of hematopoiesis [...] | ATPase family, AAA domain-containing 2B. | 0.607 |